Uriage Age Protect Multi-Action Detox Night Cream 40ml

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

1-2-hexanediol has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,1-2-hexanediol technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Reduces fine lines, stimulates collagen, firms skin, and reduces inflammation.

Why It's Used: Fda-recognized anti-wrinkle active with multi-action collagen stimulation + wrinkle reduction + anti-inflammatory efficacy.

How It Works: Activates adenosine a2a receptors on fibroblasts stimulating collagen type i. also activates pka pathway promoting atp production and reducing inflammatory cytokines.

Typically Found In: Anti-aging serums,wrinkle treatments,korean skincare

TECHNICAL DETAILS

Primary Category: Active ingredient – purine nucleoside / anti-aging

Secondary Functions: Collagen stimulation,anti-inflammatory,cell energy

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.04%–0.1%

SOURCING & ETHICS

Vegan Status: Yes – synthetically produced

Halal Status: Yes

Source Notes: Synthetically produced for cosmetic use.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; excellent tolerability.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. fda-recognized as safe and effective anti-wrinkle ingredient. ewg score: 1.

Works Well With: Other b vitamins,niacinamide,antioxidant complexes

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

A 2002 clinical study demonstrated 0.04% adenosine cream significantly reduced wrinkle depth and increased skin elasticity after 4 weeks. fda recognition requires controlled clinical trial evidence.

Last Verified: Cosing database,adenosine anti-aging clinical data,fda otc anti-wrinkle monograph

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides gram-negative focused preservation complementary to phenoxyethanol for comprehensive spectrum coverage.

Why It's Used: Phenoxyethanol complement — chlorphenesin's gram-negative and antifungal coverage complements phenoxyethanol's gram-positive activity for full-spectrum preservation at lower individual concentrations.

How It Works: 4-chlorophenol ether glycol disrupts bacterial and fungal membranes. strong gram-negative activity (pseudomonas, e. coli). good candida antifungal activity. used with phenoxyethanol for synergistic broad-spectrum coverage. ph stable 3-9.

Typically Found In: Comprehensive preservation systems,baby products (low concentration)

TECHNICAL DETAILS

Primary Category: Functional ingredient – glycerol ether preservative

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–0.3%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Eu max 0.3% cosmetics. good safety profile. synergistic combination with phenoxyethanol (0.3% pe + 0.1% chlorphenesin often equivalent to 1% pe alone).

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Chlorphenesin + phenoxyethanol synergy operates through a classic spectrum-filling combination: phenoxyethanol provides strong gram-positive antimicrobial activity while chlorphenesin provides gram-negative and antifungal coverage. the combination's minimum inhibitory concentration sum is subadditive (provides equivalent preservation at combined concentrations below what either alone would require) — textbook pharmacological synergy enabling lower total preservative load.

Last Verified: Cosing database,eu preservative annex v,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function — skin conditioning, protection, preservation, or active biological benefit — at recommended use concentration.

Why It's Used: Selected for its functional contribution and formulation compatibility — supported by cosmetic science literature and regulatory safety assessment.

How It Works: Works through the mechanism of its molecular class — physicochemical interaction with the formulation or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Diglycerin delivers documented functional benefit with an established safety profile within the cosmetic regulatory framework (cosing eu, cir usa).

Last Verified: Cosing database,diglycerin technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides silicone-characteristic silky feel and skin protection with adjustable viscosity.

Why It's Used: The benchmark cosmetic silicone – sets the gold standard for silky application feel, spreadability, and skin protection in virtually all skin care categories.

How It Works: Polydimethylsiloxane chain flexibility provides extremely low surface tension and high spreadability. inert si-o backbone provides chemical stability and excellent skin tolerance. occlusive film formation reduces tewl. higher viscosity grades provide more intense conditioning.

Typically Found In: Moisturizers,foundations,primers,sunscreens – nearly universal

TECHNICAL DETAILS

Primary Category: Functional ingredient – polydimethylsiloxane

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–30%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Dimethicone's exceptional silky feel arises from its very low intermolecular attractive forces (weak van der waals forces due to non-polar methyl groups) that allow silicone chains to slide freely over skin. the coefficient of kinetic friction for pdms against skin (~0.04) is among the lowest of any cosmetic material – explaining why even small amounts transform product feel.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.

Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.

How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.

Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners

TECHNICAL DETAILS

Primary Category: Humectant

Secondary Functions: Skin barrier support,emollient,solvent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–30% (typical: 3–10%)

SOURCING & ETHICS

Vegan Status: Yes – plant-derived (coconut, soy, palm) or synthetic

Halal Status: Yes – when plant-derived or synthetic; verify source with supplier

Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; non-irritating at all standard concentrations

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).

Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas

Avoid Combining With: No known incompatibilities at standard concentrations

SCIENTIFIC NOTE

Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides quick-dry volatile hydrocarbon carrier for colour cosmetics with complete evaporation and no residue.

Why It's Used: Primary colour cosmetic carrier — isododecane's volatility and excellent pigment dispersion combined with complete evaporation make it the standard carrier for long-wear foundations and colour cosmetics.

How It Works: Volatile isoparaffin (bp 177-188°c) evaporates from skin within 10-20 minutes. excellent pigment dispersion for colour cosmetics. spreading enhancement from low surface tension. no residue after evaporation provides clean, long-wear finish.

Typically Found In: Long-wear foundations,colour cosmetics,primers,sunscreens

TECHNICAL DETAILS

Primary Category: Functional ingredient – volatile hydrocarbon

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 5%–60%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Isododecane's position as the preferred colour cosmetic carrier arises from a unique combination of properties that no other solvent provides simultaneously: volatility (complete evaporation for clean finish), pigment dispersion (superior to water or alcohols), compatibility with silicones (unlike many solvents), and skin safety (inert hydrocarbon without irritation potential of polar solvents).

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides natural phospholipid emulsification with barrier-compatible delivery and liposome-forming properties.

Why It's Used: The most biologically authentic emulsifier – identical to cell membrane composition providing barrier-compatible delivery and liposome formation unavailable from synthetic emulsifiers.

How It Works: Phosphatidylcholine (pc), phosphatidylethanolamine (pe), phosphatidylinositol (pi) mixture provides hlb 7-12 for o/w emulsification. forms liposomal bilayers for active encapsulation. pc/pe/pi composition mirrors cell membrane for barrier-compatible delivery.

Typically Found In: Natural cosmetics,liposomal products,barrier repair,penetration-enhanced formulas

TECHNICAL DETAILS

Primary Category: Functional ingredient – natural phospholipid emulsifier

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–10%

SOURCING & ETHICS

Vegan Status: Conditional – soy lecithin (vegan); egg lecithin (not vegan)

Halal Status: Conditional – soy (halal); egg (verify)

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Lecithin's phospholipid composition mirrors the composition of the stratum corneum's own lamellar bodies that deliver barrier lipids to the skin surface. this structural mimicry allows lecithin-based delivery systems to integrate seamlessly with the barrier lipid structure, exploiting the same transport pathway the skin uses for its own lipid secretion.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

O-cymen-5-ol has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,o-cymen-5-ol technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides hygroscopic moisture retention from the multiple hydroxyl groups, conditions skin from the polyol's sc-compatible chemistry, and serves as the hydrophilic cosmos-accepted backbone for polyglyceryl fatty acid ester synthesis.

Why It's Used: Polyglycerin-3 provides the natural polyol humectancy of glycerin with higher mw and more oh groups per molecule — superior moisture retention for high-performance natural formulations.

How It Works: Polyglycerin-3 (from glycerol polycondensation, degree 3): mw ~186 da, 7 oh groups. oh density per gram higher than single glycerol providing superior water binding. cosmos accepted from vegetable glycerol polycondensation.

Typically Found In: Natural humectants,cosmos formulas

TECHNICAL DETAILS

Primary Category: Active ingredient – humectant

Secondary Functions: Moisture retention,hydration

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–15%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived or fermentation-produced.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for sensitive skin.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,barrier actives

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Polyglycerin-3 is the cosmos-accepted hydrophilic backbone for polyglyceryl fatty acid ester emulsifiers — the specific polyglyceryl degree determines the hlb of the resulting ester for o/w (pg-6-10) or w/o (pg-2-4) emulsification.

Last Verified: Cosing database,polyglycerin-3 polyol humectant review

Primary Sources: 2026-03-22