Treecell Night Collagen Shampoo Midnight Forest

DESCRIPTION

What It Does: Conditions skin, attracts moisture, supports wound healing, and improves microcirculation via no synthesis.

Why It's Used: Multi-functional amino acid for skin hydration, conditioning, and wound healing in peptide and nmf formulations.

How It Works: Guanidinium group binds water (humectant). substrate for nitric oxide synthase (enos) producing nitric oxide that vasodilates capillaries improving skin nutrition. stimulates fibroblast proliferation for wound healing.

Typically Found In: Anti-aging serums,wound healing products,nmf moisturizers,scalp treatments

TECHNICAL DETAILS

Primary Category: Active ingredient – amino acid

Secondary Functions: Wound healing,microcirculation,nmf component

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes – plant-derived or synthetic

Halal Status: Yes

Source Notes: Fermentation-derived or synthetic. natural skin component.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; endogenous skin molecule.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. natural skin nmf component. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,peptides,other amino acids

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Arginine is a conditionally essential amino acid in wound healing where local demand exceeds synthesis capacity. topical arginine provides the nos substrate locally for no-mediated vasodilation and immune cell function in healing tissue.

Last Verified: Cosing database,cir safety assessment,witte & barbul arginine wound healing review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Stimulates lipolysis in adipocytes by inhibiting phosphodiesterase (preventing camp breakdown), reduces eye puffiness through vasoconstriction of periorbital capillaries, and provides antioxidant dna repair stimulation for photoprotective benefit.

Why It's Used: The only cosmetic active with a well-defined mechanism for anti-cellulite claims — phosphodiesterase inhibition elevating adipocyte camp is the documented biochemical pathway, providing mechanism-based efficacy substantiation superior to most slimming actives.

How It Works: Caffeine inhibits phosphodiesterase (pde3, pde4) preventing camp hydrolysis → elevated camp activates protein kinase a → phosphorylates hormone-sensitive lipase → lipolysis of triglycerides in adipocytes. for eye puffiness: caffeine's adenosine receptor antagonism reduces prostaglandin-mediated capillary dilation in periorbital tissue, reducing fluid accumulation.

Typically Found In: Anti-cellulite,eye creams,antioxidant products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–3%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Caffeine has one of the highest sc penetration rates of any cosmetic active (logp -0.07, mw 194 da) — the combination of small size and moderate logp providing excellent aqueous solubility with sufficient sc lipid partitioning for effective transdermal delivery to adipose tissue.

Last Verified: Cosing database,caffeine pde inhibitor anti-cellulite lipolysis review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers targeted skin-conditioning or bioactive benefits through a specific mechanism of action suited to the formulation's intended purpose.

Why It's Used: Specialty actives address specific skin concerns through targeted molecular mechanisms, providing efficacy beyond what base formulation ingredients alone can achieve.

How It Works: The bioactive compound interacts with specific molecular targets in skin cells or the extracellular matrix — enzymes, receptors, structural proteins, or signaling molecules — triggering beneficial biological responses.

Typically Found In: Serums,treatments,moisturizers,specialty products

TECHNICAL DETAILS

Primary Category: Specialty actives

Secondary Functions: Skin-conditioning,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01–5%

SOURCING & ETHICS

Vegan Status: No

Halal Status: Conditional

Source Notes: Contains animal-derived components (collagen...); not suitable for vegan formulations.

SKIN COMPATIBILITY

Irritancy Rating: 1

Comedogenicity Rating: 0

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Conditional

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Niacinamide,hyaluronic acid,vitamin c,peptides

Avoid Combining With: Incompatible with oxidizing agents; check ph stability

SCIENTIFIC NOTE

Specialty actives typically work through enzyme inhibition (e.g., tyrosinase inhibition for brightening, mmp inhibition for anti-aging), receptor activation (e.g., retinoid receptors, ppar-γ for barrier genes), or transcription factor modulation (e.g., nrf2 for antioxidant gene upregulation). structure-activity relationships determine potency and selectivity.

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; ingredient-specific safety and efficacy literature

Primary Sources: 2025-01-15

DESCRIPTION

What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.

Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.

How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.

Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners

TECHNICAL DETAILS

Primary Category: Humectant

Secondary Functions: Skin barrier support,emollient,solvent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–30% (typical: 3–10%)

SOURCING & ETHICS

Vegan Status: Yes – plant-derived (coconut, soy, palm) or synthetic

Halal Status: Yes – when plant-derived or synthetic; verify source with supplier

Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; non-irritating at all standard concentrations

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).

Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas

Avoid Combining With: No known incompatibilities at standard concentrations

SCIENTIFIC NOTE

Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers targeted skin-conditioning or bioactive benefits through a specific mechanism of action suited to the formulation's intended purpose.

Why It's Used: Specialty actives address specific skin concerns through targeted molecular mechanisms, providing efficacy beyond what base formulation ingredients alone can achieve.

How It Works: The bioactive compound interacts with specific molecular targets in skin cells or the extracellular matrix — enzymes, receptors, structural proteins, or signaling molecules — triggering beneficial biological responses.

Typically Found In: Serums,treatments,moisturizers,specialty products

TECHNICAL DETAILS

Primary Category: Specialty actives

Secondary Functions: Skin-conditioning,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Specialty active ingredient; check individual sourcing for vegan status.

SKIN COMPATIBILITY

Irritancy Rating: 1

Comedogenicity Rating: 0

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Niacinamide,hyaluronic acid,vitamin c,peptides

Avoid Combining With: Incompatible with oxidizing agents; check ph stability

SCIENTIFIC NOTE

Specialty actives typically work through enzyme inhibition (e.g., tyrosinase inhibition for brightening, mmp inhibition for anti-aging), receptor activation (e.g., retinoid receptors, ppar-γ for barrier genes), or transcription factor modulation (e.g., nrf2 for antioxidant gene upregulation). structure-activity relationships determine potency and selectivity.

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; ingredient-specific safety and efficacy literature

Primary Sources: 2025-01-15

DESCRIPTION

What It Does: Provides potent antimicrobial and preservation boosting activity for clean-label preservation systems.

Why It's Used: The most potent glycol preservative booster in common cosmetic use, enabling effective preservation at minimal primary preservative concentrations.

How It Works: C6 chain length provides optimal antimicrobial membrane activity for glycol preservative boosters. excellent synergy with caprylyl glycol and ethylhexylglycerin for comprehensive preservative systems. skin conditioning from diol humectant activity.

Typically Found In: K-beauty formulas,natural formulations,clean beauty preservation systems

TECHNICAL DETAILS

Primary Category: Functional ingredient – c6 glycol preservative booster

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–3%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

The antimicrobial activity of 1,2-diols correlates precisely with carbon chain length: c3 (pg) < c4 (bg) < c5 (pentylene glycol) < c6 (hexanediol) < c8 (caprylyl glycol). 1,2-hexanediol sits at the sweet spot of effective antimicrobial activity combined with good water solubility and low skin sensitization, making it the most widely used glycol preservative booster.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides documented cosmetic activity from isopropanolamine.

Why It's Used: Isopropanolamine delivers formulation value through its specific biological activity and established safety and efficacy.

How It Works: Source: isopropanolamine. mechanism: documented in cosmetic literature. safety: cosing-reviewed. standard cosmetic use concentrations.

Typically Found In: Skin care formulations,active products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Isopropanolamine provides cosmetic activity through its characteristic mechanism. at standard concentrations it delivers documented biological activity with an established safety profile from cosmetic science literature and regulatory review.

Last Verified: Cosing database,isopropanolamine technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Laureth-23 has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,laureth-23 technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides film-forming conditioning and detangling with heat protection in a polymer that adsorbs substantively to hair.

Why It's Used: The most widely used cationic polymer conditioner – provides excellent conditioning and detangling while adsorbing strongly to damaged hair areas that need conditioning most.

How It Works: Cationic quaternary ammonium groups along the polymer backbone adsorb to anionic sites on hair keratin. higher charge density on damaged hair (more negative sites) leads to preferential adsorption where conditioning is needed. polymer film formation provides heat protection and volume.

Typically Found In: Shampoos,2-in-1 products,conditioners,styling products

TECHNICAL DETAILS

Primary Category: Functional ingredient – cationic polymer conditioner

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – cellulose-derived

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Polyquaternium-10's 'self-targeting' to damaged hair sites is a unique smart conditioning mechanism. as hair damage increases negative charge density by exposing keratin's aspartate and glutamate carboxylate groups, pq-10's cationic polymer backbone adsorbs preferentially to these high-charge damage sites – automatically delivering more conditioning where the hair needs it most.

Last Verified: Cosing database,robbins hair science,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Deposits a conditioning film on hair and skin through electrostatic attraction to negative cuticle/corneocyte surfaces, reduces hair-on-hair friction for improved combability and detangling, eliminates static charge buildup, and provides anti-frizz humidity resistance.

Why It's Used: Cationic polymers are the primary hair conditioning technology — the permanent positive quaternary ammonium groups provide substantive deposition that resists rinsing, delivering persistent conditioning between washes unlike small-molecule cationic conditioners.

How It Works: At shampoo/conditioner ph 4.5–5.5, hair cuticle carries net negative charge (isoelectric point ph ~3.5). polyquaternium cations undergo electrostatic attraction depositing on the cuticle surface. during rinsing, the deposited polymer film persists from reduced surface-solution equilibrium at low bulk concentration — substantive deposition from favourable interfacial versus bulk partitioning.

Typically Found In: Shampoos,conditioners,leave-in products

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–3%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Different polyquaternium numbers indicate different backbone chemistries: pq-7 (acrylamide/quaternary acrylate copolymer) for leave-on flexibility; pq-10 (hydroxyethylcellulose/quaternary ammonium) for substantive deposition; pq-11 (vp/dimethylaminoethyl methacrylate) for styling fixation.

Last Verified: Cosing database,polyquaternium-7 cationic conditioning deposition review

Primary Sources: 2026-03-12