Sheibe
Sheibe Hair Biologist Age-Reversal Ampoule
The Sheibe Hair Biologist Age-Reversal Ampoule is a hair treatment designed to combat hair thinning, hair loss, and graying. It utilizes Swiss-patented Darkenyl™ black hair peptide at a concentration of 12,000 ppm to promote melanin production, effectively reducing gray hair. Clinical trials have shown a 17% reduction in gray hair over four months, with some users experiencing a decrease from 90% to 40% gray hair. The formula also includes European larch wood extract, glycine, and tea leaf extract to enhance antioxidant capacity and delay follicle aging. Additionally, the product features a patented Nanobubble technology to increase ingredient penetration and absorption. Manufactured in Japan, it is free from harmful substances such as formaldehyde, heavy metals, and dioxane, making it suitable for individuals over six years old, including pregnant and breastfeeding women.
Sulfate-free
Paraben-free
Color-safe
Silicone-free
Natural
Protein-free
Optimized for Your Environment & Lifestyle
Nykaa
In stock
Recommended
Sheibe Hair Biologist Age-Reversal Ampoule
Sheibe
sheibe-hair-biologist-age-reversal-ampoule
Hair Treatment Ampoule
10523355808037
Morning or Evening?
How often will you use this product?
Notes
Secure payment protection
Your Biodata Compatibility Analysis
Based on your 6 hair health indices and environmental factors
Poor Match
Significant incompatibilities
Growth Cycle Health Index
Hair Match
Hair Health Index Alignment
Optimal for OSI, SSI, DI, HSI
Ingredient Efficacy
Matching Ingredient Score
Environment Compatibility
Current UV, Air Quality & Humidity
Why This Works for Your Specific Profile
Damage Index:
Damage levels outside specified range may not benefit optimally from product formulation
Water Quality:
Sensitive scalps experience irritation from active ingredients formulated for resilient skin
Hair:
No porosity-specific conflicts
Active Lifestyle:
Activity levels outside optimal range affect product performance and maintenance requirements
Your Hair Profile Integration
Your Hair Archetype
Density Level
Washing Frequency
Shedding Level
Oil Level
Your Hair Health Indices
Oil Secretion (OSI)
Very low oil production
Scalp Sensitivity (SSI)
Very low sensitivity
Growth Rate (CMR)
Poor metabolism rate
Damage Index (DI)
Minimal damage
Hair Strength (HSI)
Very weak strength
Softness Index (SI)
Significant improvement needed
Water & Environmental Integration
Water:
Expected Results & Timeline
Key Highlights
What is it?
Hair treatment ampoule containing 13 natural ingredients
Who Is It For
Individuals over 6 years old, including pregnant and breastfeeding women
Budget
$30.16 - $60.32
Timeline
Clinical trials have shown a 17% reduction in gray hair over four months
Why You’ll Love It
What Does It Help With?
Reducing gray hair, preventing hair loss, promoting hair growth
Best for
Hair loss and graying
Features
Contains 12,000 ppm of Darkenyl™ black hair peptide, utilizes Nanobubble technology for enhanced absorption, clinically proven to reduce gray hair by 17% over four months, free from harmful substances like formaldehyde and heavy metals
Checks
GMP/ISO certified, SGS tested for safety
Ingredients Overview
Ingredients List
darkenyl™, european-larch-wood-extract, glycine, tea-leaf-extract, dipotassium-glycyrrhizate, menthol, ceramide-np, oregano-leaf-extract, sage-leaf-extract, scutellaria-root-extract, soybean-seed-extract-water, sodium-hyaluronate, sodium-acetylated-hyaluronate
Key Ingredients
darkenyl™, european-larch-wood-extract, glycine, tea-leaf-extract
Ingredients Details
Glycine
Common Name(s): Aminoacetic acid,aminoethanoic acid,h-gly-oh
CAS Number: 56-40-6
DESCRIPTION
What It Does: Provides nmf amino acid skin conditioning and collagen-constituent support.
Why It's Used: The collagen amino acid — glycine is the most abundant amino acid in collagen (every third residue in the triple helix is glycine) making topical glycine the most physiologically relevant collagen-support amino acid.
How It Works: Nmf component via zwitterionic water retention. collagen triple helix requires gly-x-y repeat where glycine's small size allows close packing. wound healing via fibroblast glutathione synthesis support. anti-inflammatory via glycine-gated chloride channel activation (inhibitory neuromodulator).
Typically Found In: Skin conditioning products,wound healing,nmf moisturisers
TECHNICAL DETAILS
Primary Category: Active ingredient – simplest amino acid
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%–5%
SOURCING & ETHICS
Vegan Status: Yes – fermentation or synthetic
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Glycine's mandatory presence at every third position in collagen's triple helix (gly-x-y repeat) arises from its unique zero side-chain structure — only glycine is small enough to fit at the sterically restricted centre of the triple helix where the three polypeptide chains cross. no other amino acid can substitute for glycine in the collagen triple helix without disrupting the structure, making glycine irreplaceable in collagen biology.
Last Verified: Cosing database,cir safety assessment
Primary Sources: 2026-03-12
Glycine
Common Name(s): Aminoacetic acid,aminoethanoic acid,h-gly-oh
CAS Number: 56-40-6
DESCRIPTION
What It Does: Provides nmf amino acid skin conditioning and collagen-constituent support.
Why It's Used: The collagen amino acid — glycine is the most abundant amino acid in collagen (every third residue in the triple helix is glycine) making topical glycine the most physiologically relevant collagen-support amino acid.
How It Works: Nmf component via zwitterionic water retention. collagen triple helix requires gly-x-y repeat where glycine's small size allows close packing. wound healing via fibroblast glutathione synthesis support. anti-inflammatory via glycine-gated chloride channel activation (inhibitory neuromodulator).
Typically Found In: Skin conditioning products,wound healing,nmf moisturisers
TECHNICAL DETAILS
Primary Category: Active ingredient – simplest amino acid
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.5%–5%
SOURCING & ETHICS
Vegan Status: Yes – fermentation or synthetic
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Glycine's mandatory presence at every third position in collagen's triple helix (gly-x-y repeat) arises from its unique zero side-chain structure — only glycine is small enough to fit at the sterically restricted centre of the triple helix where the three polypeptide chains cross. no other amino acid can substitute for glycine in the collagen triple helix without disrupting the structure, making glycine irreplaceable in collagen biology.
Last Verified: Cosing database,cir safety assessment
Primary Sources: 2026-03-12
Menthol
Common Name(s): L-menthol,peppermint camphor,(-)-menthol
CAS Number: 89-78-1
DESCRIPTION
What It Does: Activates trpm8 cold thermoreceptors for intense cooling sensation and analgesic activity.
Why It's Used: The most potent cosmetic cooling agent – direct trpm8 agonist providing cooling sensation without actual temperature reduction for refreshing and analgesic formulations.
How It Works: Potent trpm8 (menthol receptor/cold thermosensor) agonist – activation at room temperature mimics cold sensation without actual cooling. anti-pruritic via trpm8 activation competing with itch c-fiber signaling. antimicrobial via membrane disruption.
Typically Found In: Cooling products,scalp treatments,oral care,pain relief,foot care,after-sun
TECHNICAL DETAILS
Primary Category: Active ingredient – cooling sensory terpenoid
Secondary Functions: Redness reduction,anti-inflammatory,calming
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–2%
SOURCING & ETHICS
Vegan Status: Yes – from mentha piperita or synthetic
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 2/5 – low to moderate; potential sensitizer
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.
Safe for Sensitive Skin: Avoid near eyes. use with caution at concentrations above 1% for sensitive skin.
SAFETY & COMPATIBILITY
Safety Profile: Eu max 4.5% (leave-on); regulations vary by application site. avoid on infants' face.
Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Menthol's exceptional cooling potency stems from its ec50 for trpm8 activation of approximately 10μm (vs camphor's ec50 of ~5mm – 500× lower potency). this 500× potency advantage explains why even tiny concentrations of menthol provide intense cooling, while much higher concentrations of camphor are required for equivalent sensation.
Last Verified: Cosing database,mckemy et al. menthol trpm8 discovery,cir safety assessment
Primary Sources: 2026-03-12
Personalized Usage Instructions
How to Use
Step 1
Shake the ampoule bottle gently to activate Nanobubble technology
Step 2
Spray onto the scalp, hairline, and areas with gray hair
Step 3
Gently massage for 3-5 minutes to ensure absorption
Step 4
No need to rinse
Step 5
Use daily for optimal results
Medical Chemicals
Protein/Moisture
- Protein/Moisture balance
pH Level
- Acidic
Porosity Taget
- Normal Porosity
Customized for Your Profile
Scalp Condtions
Anti-Dandruff, Seborrheic Dermatitis Safe, Sensitive Scalp, pH Balanced, Oil Control, Dry Scalp
Climate Suitability
Humid, Dry, Hard Water, Soft Water, UV Protection, Pollution Shield, Winter, Summer
Clinical Claims
Clinical trials indicate a 17% reduction in gray hair over four months, with some users experiencing a decrease from 90% to 40% gray hair
Frequency
Shake the ampoule bottle gently to activate Nanobubble technology. Spray onto the scalp, hairline, and areas with gray hair. Gently massage for 3-5 minutes to ensure absorption. No need to rinse. Use daily for optimal results.
Product Information
GMP/ISO certified
SGS tested for safety
