Sebamed Lip Defense Cherry 4.8Gm

DESCRIPTION

What It Does: Kills bacteria, fungi, and viruses on skin and within formulations through membrane disruption, protein denaturation, or enzyme inhibition — providing antiseptic, preservation, or therapeutic antimicrobial protection.

Why It's Used: Chosen when broad-spectrum antimicrobial coverage including gram-negative bacteria (particularly pseudomonas) is required, where standard cosmetic preservatives provide insufficient protection for challenge tests.

How It Works: Cationic biocides (qacs) adsorb electrostatically to negative microbial surfaces then insert hydrophobic chains into lipid bilayers, collapsing membrane potential. non-ionic biocides (triclosan) inhibit fatty acid synthesis (fabi enoyl reductase). oxidants (h₂o₂, chlorine dioxide) oxidise microbial thiol enzymes non-specifically.

Typically Found In: Antiseptics,therapeutic skin care

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: Check regulatory limits

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Regulatory limits vary significantly by compound and application — formulators must verify permitted concentrations in target market (eu annex v, fda otc monographs) before formulating at functional concentrations.

Last Verified: Cosing database,bis-ethylhexyloxyphenol methoxyphenyl triazine antimicrobial regulatory review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Reduces skin inflammation, soothes irritation, promotes wound healing, and enhances penetration of co-formulated actives.

Why It's Used: Premium natural soothing active with combined anti-inflammatory, wound healing, and penetration-enhancing activity – clinically validated across sensitive, reactive, and irritated skin types.

How It Works: Inhibits nf-kb pathway reducing pro-inflammatory cytokines il-1β, il-6, tnf-α. enhances stratum corneum lipid fluidity increasing penetration of co-delivered actives. antimicrobial against s. aureus and c. albicans. promotes keratinocyte migration for wound healing.

Typically Found In: Sensitive skin products,post-procedure formulations,anti-irritant formulas,wound healing

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Anti-inflammatory,penetration enhancement,antimicrobial

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–1%

SOURCING & ETHICS

Vegan Status: Yes – from candeia tree (vanillosmopsis erythropappa) or synthetic

Halal Status: Yes

Source Notes: Natural (-)-alpha-bisabolol from brazilian candeia tree is more sustainable and potent than chamomile-derived bisabolol. synthetic (±)-bisabolol is racemic with slightly lower anti-inflammatory potency.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Bisabolol's dual function as both an anti-inflammatory and a penetration enhancer is synergistic – by reducing the inflammatory response that increases barrier tightness while simultaneously fluidizing stratum corneum lipids, it provides enhanced delivery of co-formulated actives in the very conditions where delivery is most needed.

Last Verified: Cosing database,piazza et al. bisabolol anti-inflammatory study,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

C12-15 alkyl benzoate has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,c12-15 alkyl benzoate technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers targeted skin-conditioning or bioactive benefits through a specific mechanism of action suited to the formulation's intended purpose.

Why It's Used: Specialty actives address specific skin concerns through targeted molecular mechanisms, providing efficacy beyond what base formulation ingredients alone can achieve.

How It Works: The bioactive compound interacts with specific molecular targets in skin cells or the extracellular matrix — enzymes, receptors, structural proteins, or signaling molecules — triggering beneficial biological responses.

Typically Found In: Serums,treatments,moisturizers,specialty products

TECHNICAL DETAILS

Primary Category: Specialty actives

Secondary Functions: Skin-conditioning,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Specialty active ingredient; check individual sourcing for vegan status.

SKIN COMPATIBILITY

Irritancy Rating: 1

Comedogenicity Rating: 0

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Niacinamide,hyaluronic acid,vitamin c,peptides

Avoid Combining With: Incompatible with oxidizing agents; check ph stability

SCIENTIFIC NOTE

Specialty actives typically work through enzyme inhibition (e.g., tyrosinase inhibition for brightening, mmp inhibition for anti-aging), receptor activation (e.g., retinoid receptors, ppar-γ for barrier genes), or transcription factor modulation (e.g., nrf2 for antioxidant gene upregulation). structure-activity relationships determine potency and selectivity.

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; ingredient-specific safety and efficacy literature

Primary Sources: 2025-01-15

DESCRIPTION

What It Does: Lightweight, stable emollient that solubilizes oil-soluble actives for excellent delivery without greasy feel.

Why It's Used: Universal lightweight emollient base and solubilizer for oil-soluble actives in serums and low-viscosity formulations where mineral oil or petrolatum would be too heavy.

How It Works: Medium-chain length provides ideal balance of spreading coefficient, penetration rate, and barrier-sealing properties. excellent solubilizer for vitamin e, retinoids, and other lipophilic actives.

Typically Found In: Serums,facial oils,sunscreens,anti-aging products,hair products

TECHNICAL DETAILS

Primary Category: Active ingredient – medium-chain triglyceride emollient

Secondary Functions: Active solubilizer,spreading agent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–50%

SOURCING & ETHICS

Vegan Status: Yes – from coconut/palm kernel oil

Halal Status: Yes

Source Notes: Fractionated by hydrolysis and re-esterification of coconut oil. only c8 and c10 fatty acids retained.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – very low; medium-chain length generally non-comedogenic

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Mct oil's medium-chain length (c8/c10) provides superior oxidative stability vs longer polyunsaturated chains and better skin aesthetics (lighter, less greasy) vs longer chain emollients (c16/c18). excellent solubilizer for retinoic acid, tocopheryl esters, and other lipophilic actives.

Last Verified: Cosing database,cir safety assessment,ewg skin deep

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Structures lip balms and anhydrous formulations through the wax crystal network, provides occlusive barrier protection reducing tewl, and conditions skin with the emollient fatty acids and esters in the wax composition.

Why It's Used: Beeswax as a traditional wax has both structure and emollient function from its complex wax ester (c32-c36) composition.

How It Works: Beeswax forms a crystalline wax network above its melting point (beeswax ~62°c; carnauba ~83°c; candelilla ~68°c). on cooling, wax crystals nucleate and grow forming a three-dimensional network that immobilises liquid oils — providing semi-solid stick structure. wax melting point determines temperature stability range for product use conditions.

Typically Found In: Lip care,anhydrous balms,emulsions

TECHNICAL DETAILS

Primary Category: Functional ingredient – emollient

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–30%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Conditional

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Carnauba (highest melting wax at ~83°c) provides the hardest, most heat-stable wax structure; beeswax (~62°c) provides more pliable, skin-compatible structure; candelilla (~68°c) provides the vegan beeswax alternative used in certified natural and vegan formulations.

Last Verified: Cosing database,natural wax structuring emollient review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Absorbs uv radiation at specific wavelengths (uva 320–400 nm, uvb 290–320 nm) and dissipates photon energy as heat rather than skin-damaging photochemical reactions.

Why It's Used: Organic uv filters are chosen for their high molar extinction coefficient, specific spectral coverage, and formulation compatibility — individual filters are combined to provide broad-spectrum coverage across uva+uvb.

How It Works: Uv photon absorption by the aromatic chromophore π-system excites the molecule from s₀ ground state to s₁ excited state. rapid internal conversion or photoisomerisation dissipates energy as vibrational heat before it can initiate skin photodamage.

Typically Found In: Sunscreens,photoprotective products

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: Check local sunscreen regulations

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Organic uv filters require photostabilisation (by avobenzone-octocrylene pairing, or triazine stabilisers) as some absorbers degrade on uv exposure — formulator must verify photostability of the chosen filter combination.

Last Verified: Cosing database,diethylamino hydroxybenzoyl hexyl benzoate organic uv filter review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Diethylhexyl butamido triazone has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,diethylhexyl butamido triazone technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides maximum spf contribution per unit concentration from the highest-extinction-coefficient uvb filter.

Why It's Used: Most spf-efficient uvb filter — eht provides 6× more spf contribution per gram than omc, enabling high-spf formulations with minimal uv filter load.

How It Works: Three benzotriazole chromophores on triazine core provide εmax ~155,000 (vs omc ~24,000 — 6× more potent). photostable from triazine scaffold preventing chromophore photodegradation. oil-soluble for lipid phase.

Typically Found In: High-spf european sunscreens

TECHNICAL DETAILS

Primary Category: Active ingredient – efficient uvb filter

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: Up to 5% (eu)

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Eu approved. not fda approved. ewg score: 1.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Ethylhexyl triazone's εmax of ~155,000 l/mol·cm is 6× greater than omc (~24,000), 48× greater than homosalate (~3,200), and represents the practical upper limit of organic uvb filter molar absorptivity. this extraordinary absorption coefficient arises from three benzotriazole chromophores geometrically arranged on the triazine core to simultaneously absorb uvb photons — a triplex chromophore design providing additive absorptivity.

Last Verified: Cosing database,basf uvinul t 150 technical data

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides c18:1 oleic fatty acid emolliency from the glycerol ester with one glycerol position esterified providing hlb ~3–4 for o/w emulsification, plus gentle glycerol humectancy from the backbone after sc esterase hydrolysis.

Why It's Used: Glyceryl ricinoleate is selected for c18:1 oleic glyceryl ester emolliency — the glycerol carrier provides natural origin, biodegradability, and mild glycerol humectancy co-delivery alongside fluid unsaturated emolliency with lowest melting point in the glycerol ester series from the c18:1 oleic fatty acid chain.

How It Works: Glyceryl monoester: glycerol backbone → mild humectancy + natural origin; c18:1 oleic chain → fluid unsaturated emolliency with lowest melting point in the glycerol ester series; sc esterase hydrolysis → free glycerol + fatty acid metabolites.

Typically Found In: Emollient skin care,barrier repair

TECHNICAL DETAILS

Primary Category: Functional ingredient – emollient

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–30%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Glyceryl mono/diesters are biodegradable alternatives to petro-derived esters — the glycerol backbone ensures ecocert and cosmos certification compatibility.

Last Verified: Cosing database,glyceryl ricinoleate glyceryl ester emollient review

Primary Sources: 2026-03-22