RYO Deep Cleansing & Cooling Shampoo

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

1-2-hexanediol has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,1-2-hexanediol technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Stimulates lipolysis in adipocytes by inhibiting phosphodiesterase (preventing camp breakdown), reduces eye puffiness through vasoconstriction of periorbital capillaries, and provides antioxidant dna repair stimulation for photoprotective benefit.

Why It's Used: The only cosmetic active with a well-defined mechanism for anti-cellulite claims — phosphodiesterase inhibition elevating adipocyte camp is the documented biochemical pathway, providing mechanism-based efficacy substantiation superior to most slimming actives.

How It Works: Caffeine inhibits phosphodiesterase (pde3, pde4) preventing camp hydrolysis → elevated camp activates protein kinase a → phosphorylates hormone-sensitive lipase → lipolysis of triglycerides in adipocytes. for eye puffiness: caffeine's adenosine receptor antagonism reduces prostaglandin-mediated capillary dilation in periorbital tissue, reducing fluid accumulation.

Typically Found In: Anti-cellulite,eye creams,antioxidant products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–3%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Caffeine has one of the highest sc penetration rates of any cosmetic active (logp -0.07, mw 194 da) — the combination of small size and moderate logp providing excellent aqueous solubility with sufficient sc lipid partitioning for effective transdermal delivery to adipose tissue.

Last Verified: Cosing database,caffeine pde inhibitor anti-cellulite lipolysis review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Stimulates lipolysis in adipocytes by inhibiting phosphodiesterase (preventing camp breakdown), reduces eye puffiness through vasoconstriction of periorbital capillaries, and provides antioxidant dna repair stimulation for photoprotective benefit.

Why It's Used: The only cosmetic active with a well-defined mechanism for anti-cellulite claims — phosphodiesterase inhibition elevating adipocyte camp is the documented biochemical pathway, providing mechanism-based efficacy substantiation superior to most slimming actives.

How It Works: Caffeine inhibits phosphodiesterase (pde3, pde4) preventing camp hydrolysis → elevated camp activates protein kinase a → phosphorylates hormone-sensitive lipase → lipolysis of triglycerides in adipocytes. for eye puffiness: caffeine's adenosine receptor antagonism reduces prostaglandin-mediated capillary dilation in periorbital tissue, reducing fluid accumulation.

Typically Found In: Anti-cellulite,eye creams,antioxidant products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–3%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Caffeine has one of the highest sc penetration rates of any cosmetic active (logp -0.07, mw 194 da) — the combination of small size and moderate logp providing excellent aqueous solubility with sufficient sc lipid partitioning for effective transdermal delivery to adipose tissue.

Last Verified: Cosing database,caffeine pde inhibitor anti-cellulite lipolysis review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides imidazole-class antifungal activity specifically targeting malassezia for dandruff control in leave-on scalp products.

Why It's Used: Leave-on compatible anti-dandruff active – unlike zpt (limited in leave-on face products), climbazole is approved for leave-on scalp and face formulations for continuous anti-dandruff and anti-seborrheic activity.

How It Works: Imidazole ring inhibits malassezia cytochrome p450-dependent 14-alpha-lanosterol demethylase, blocking ergosterol synthesis essential for fungal cell membrane integrity. highly selective for fungal vs mammalian p450 enzymes.

Typically Found In: Leave-on scalp treatments,anti-dandruff serums,seborrheic dermatitis products

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–2%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Climbazole's imidazole mechanism (ergosterol synthesis inhibition via p450 enzyme blockade) is identical to the pharmaceutical anti-fungal ketoconazole's mechanism, but climbazole has superior safety profile for cosmetic use and explicit eu approval for leave-on scalp products where ketoconazole requires prescription status.

Last Verified: Cosing database,billhimer & luitpold climbazole anti-dandruff study

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Dextrin has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,dextrin technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antimicrobial skin conditioning with deodorant activity and preservation system enhancement.

Why It's Used: Multifunctional clean beauty preservation active — ethylhexylglycerin provides antimicrobial, deodorant, and skin conditioning in a single ingredient accepted in most natural cosmetic certification schemes.

How It Works: Glycerol ether provides antimicrobial via bacterial membrane phospholipid disruption. deodorant activity via reduction of underarm lipase enzyme activity (similar mechanism to triethyl citrate). skin conditioning from glycerol humectant component. synergistic with phenoxyethanol and diols.

Typically Found In: Natural preservation systems,deodorants,skin conditioning products

TECHNICAL DETAILS

Primary Category: Functional ingredient – antimicrobial glycerol ether

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–0.5%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Ethylhexylglycerin's deodorant mechanism is pharmacologically identical to triethyl citrate: both inhibit skin surface microbial lipase enzymes that convert odourless triglycerides to odorous free fatty acids. the glycerol ether structure of ethylhexylglycerin, combined with the 2-ethylhexyl chain, provides lipase inhibition similar to ester-based lipase inhibitors from a different chemical class.

Last Verified: Cosing database,schülke sensiva sc 10 technical data,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.

Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.

How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.

Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners

TECHNICAL DETAILS

Primary Category: Humectant

Secondary Functions: Skin barrier support,emollient,solvent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–30% (typical: 3–10%)

SOURCING & ETHICS

Vegan Status: Yes – plant-derived (coconut, soy, palm) or synthetic

Halal Status: Yes – when plant-derived or synthetic; verify source with supplier

Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; non-irritating at all standard concentrations

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).

Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas

Avoid Combining With: No known incompatibilities at standard concentrations

SCIENTIFIC NOTE

Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antioxidant protection, soothing anti-inflammatory effects, and skin-conditioning benefits through plant-derived polyphenols and phytochemicals.

Why It's Used: Plant extracts concentrate bioactive phytochemicals evolved for environmental protection — uv, microbial, and oxidative stressors — that translate to skin benefits.

How It Works: Polyphenols (flavonoids, phenolic acids) inhibit nf-κb-mediated inflammatory signaling, scavenge reactive oxygen species through electron donation, and chelate pro-oxidant metal ions to reduce oxidative skin damage.

Typically Found In: Serums,toners,moisturizers,masks,essences

TECHNICAL DETAILS

Primary Category: Botanical extracts

Secondary Functions: Antioxidant,anti-inflammatory

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1–10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract; no animal components.

SKIN COMPATIBILITY

Irritancy Rating: 1

Comedogenicity Rating: 0

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Niacinamide,hyaluronic acid,vitamin c,ceramides

Avoid Combining With: Strong oxidizing agents

SCIENTIFIC NOTE

Plant secondary metabolites (flavonoids, terpenes, phenolic acids) are biosynthesized as defense compounds against uv, herbivores, and pathogens. their anti-inflammatory activity typically derives from competitive inhibition of cox-2 and 5-lox enzymes (ic50 1–50 µm), while antioxidant activity involves single electron transfer (set) and hydrogen atom transfer (hat) mechanisms with structure-dependent rate constants.

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; phytochemical and ethnobotanical literature

Primary Sources: 2025-01-15

DESCRIPTION

What It Does: Activates trpm8 cold thermoreceptors for intense cooling sensation and analgesic activity.

Why It's Used: The most potent cosmetic cooling agent – direct trpm8 agonist providing cooling sensation without actual temperature reduction for refreshing and analgesic formulations.

How It Works: Potent trpm8 (menthol receptor/cold thermosensor) agonist – activation at room temperature mimics cold sensation without actual cooling. anti-pruritic via trpm8 activation competing with itch c-fiber signaling. antimicrobial via membrane disruption.

Typically Found In: Cooling products,scalp treatments,oral care,pain relief,foot care,after-sun

TECHNICAL DETAILS

Primary Category: Active ingredient – cooling sensory terpenoid

Secondary Functions: Redness reduction,anti-inflammatory,calming

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – from mentha piperita or synthetic

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 2/5 – low to moderate; potential sensitizer

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Avoid near eyes. use with caution at concentrations above 1% for sensitive skin.

SAFETY & COMPATIBILITY

Safety Profile: Eu max 4.5% (leave-on); regulations vary by application site. avoid on infants' face.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Menthol's exceptional cooling potency stems from its ec50 for trpm8 activation of approximately 10μm (vs camphor's ec50 of ~5mm – 500× lower potency). this 500× potency advantage explains why even tiny concentrations of menthol provide intense cooling, while much higher concentrations of camphor are required for equivalent sensation.

Last Verified: Cosing database,mckemy et al. menthol trpm8 discovery,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Activates trpm8 cold thermoreceptors for intense cooling sensation and analgesic activity.

Why It's Used: The most potent cosmetic cooling agent – direct trpm8 agonist providing cooling sensation without actual temperature reduction for refreshing and analgesic formulations.

How It Works: Potent trpm8 (menthol receptor/cold thermosensor) agonist – activation at room temperature mimics cold sensation without actual cooling. anti-pruritic via trpm8 activation competing with itch c-fiber signaling. antimicrobial via membrane disruption.

Typically Found In: Cooling products,scalp treatments,oral care,pain relief,foot care,after-sun

TECHNICAL DETAILS

Primary Category: Active ingredient – cooling sensory terpenoid

Secondary Functions: Redness reduction,anti-inflammatory,calming

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – from mentha piperita or synthetic

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 2/5 – low to moderate; potential sensitizer

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Avoid near eyes. use with caution at concentrations above 1% for sensitive skin.

SAFETY & COMPATIBILITY

Safety Profile: Eu max 4.5% (leave-on); regulations vary by application site. avoid on infants' face.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Menthol's exceptional cooling potency stems from its ec50 for trpm8 activation of approximately 10μm (vs camphor's ec50 of ~5mm – 500× lower potency). this 500× potency advantage explains why even tiny concentrations of menthol provide intense cooling, while much higher concentrations of camphor are required for equivalent sensation.

Last Verified: Cosing database,mckemy et al. menthol trpm8 discovery,cir safety assessment

Primary Sources: 2026-03-12