ReFa Heart Hair Mist Base Floral Soap 150ml

DESCRIPTION

What It Does: Provides nmf-type humectant moisture retention and skin conditioning.

Why It's Used: Simple, well-tolerated nmf amino acid humectant for skin conditioning formulations.

How It Works: Small methyl side chain contributes to protein hydrophobic core but as free amino acid provides direct humectant activity via amino and carboxyl groups. converted to pyruvate for cellular atp production via gluconeogenesis.

Typically Found In: Nmf moisturizers,skin conditioning products

TECHNICAL DETAILS

Primary Category: Active ingredient – amino acid

Secondary Functions: Nmf component,cellular energy

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes – plant-derived or synthetic

Halal Status: Yes

Source Notes: Fermentation-derived or synthetic. natural skin component.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; endogenous skin molecule.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. natural skin nmf component. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,peptides,other amino acids

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Free alanine is among the most abundant amino acids in the stratum corneum nmf, where it contributes to the aqueous phase hydration that keeps the stratum corneum flexible and functional.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides nmf-type humectant moisture retention and skin conditioning.

Why It's Used: Simple, well-tolerated nmf amino acid humectant for skin conditioning formulations.

How It Works: Small methyl side chain contributes to protein hydrophobic core but as free amino acid provides direct humectant activity via amino and carboxyl groups. converted to pyruvate for cellular atp production via gluconeogenesis.

Typically Found In: Nmf moisturizers,skin conditioning products

TECHNICAL DETAILS

Primary Category: Active ingredient – amino acid

Secondary Functions: Nmf component,cellular energy

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes – plant-derived or synthetic

Halal Status: Yes

Source Notes: Fermentation-derived or synthetic. natural skin component.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; endogenous skin molecule.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. natural skin nmf component. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,peptides,other amino acids

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Free alanine is among the most abundant amino acids in the stratum corneum nmf, where it contributes to the aqueous phase hydration that keeps the stratum corneum flexible and functional.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Conditions skin, attracts moisture, supports wound healing, and improves microcirculation via no synthesis.

Why It's Used: Multi-functional amino acid for skin hydration, conditioning, and wound healing in peptide and nmf formulations.

How It Works: Guanidinium group binds water (humectant). substrate for nitric oxide synthase (enos) producing nitric oxide that vasodilates capillaries improving skin nutrition. stimulates fibroblast proliferation for wound healing.

Typically Found In: Anti-aging serums,wound healing products,nmf moisturizers,scalp treatments

TECHNICAL DETAILS

Primary Category: Active ingredient – amino acid

Secondary Functions: Wound healing,microcirculation,nmf component

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes – plant-derived or synthetic

Halal Status: Yes

Source Notes: Fermentation-derived or synthetic. natural skin component.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; endogenous skin molecule.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. natural skin nmf component. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,peptides,other amino acids

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Arginine is a conditionally essential amino acid in wound healing where local demand exceeds synthesis capacity. topical arginine provides the nos substrate locally for no-mediated vasodilation and immune cell function in healing tissue.

Last Verified: Cosing database,cir safety assessment,witte & barbul arginine wound healing review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Conditions skin, attracts moisture, supports wound healing, and improves microcirculation via no synthesis.

Why It's Used: Multi-functional amino acid for skin hydration, conditioning, and wound healing in peptide and nmf formulations.

How It Works: Guanidinium group binds water (humectant). substrate for nitric oxide synthase (enos) producing nitric oxide that vasodilates capillaries improving skin nutrition. stimulates fibroblast proliferation for wound healing.

Typically Found In: Anti-aging serums,wound healing products,nmf moisturizers,scalp treatments

TECHNICAL DETAILS

Primary Category: Active ingredient – amino acid

Secondary Functions: Wound healing,microcirculation,nmf component

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes – plant-derived or synthetic

Halal Status: Yes

Source Notes: Fermentation-derived or synthetic. natural skin component.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; endogenous skin molecule.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. natural skin nmf component. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,peptides,other amino acids

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Arginine is a conditionally essential amino acid in wound healing where local demand exceeds synthesis capacity. topical arginine provides the nos substrate locally for no-mediated vasodilation and immune cell function in healing tissue.

Last Verified: Cosing database,cir safety assessment,witte & barbul arginine wound healing review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides nmf amino acid skin conditioning and collagen-constituent support.

Why It's Used: The collagen amino acid — glycine is the most abundant amino acid in collagen (every third residue in the triple helix is glycine) making topical glycine the most physiologically relevant collagen-support amino acid.

How It Works: Nmf component via zwitterionic water retention. collagen triple helix requires gly-x-y repeat where glycine's small size allows close packing. wound healing via fibroblast glutathione synthesis support. anti-inflammatory via glycine-gated chloride channel activation (inhibitory neuromodulator).

Typically Found In: Skin conditioning products,wound healing,nmf moisturisers

TECHNICAL DETAILS

Primary Category: Active ingredient – simplest amino acid

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes – fermentation or synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Glycine's mandatory presence at every third position in collagen's triple helix (gly-x-y repeat) arises from its unique zero side-chain structure — only glycine is small enough to fit at the sterically restricted centre of the triple helix where the three polypeptide chains cross. no other amino acid can substitute for glycine in the collagen triple helix without disrupting the structure, making glycine irreplaceable in collagen biology.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides nmf amino acid skin conditioning and collagen-constituent support.

Why It's Used: The collagen amino acid — glycine is the most abundant amino acid in collagen (every third residue in the triple helix is glycine) making topical glycine the most physiologically relevant collagen-support amino acid.

How It Works: Nmf component via zwitterionic water retention. collagen triple helix requires gly-x-y repeat where glycine's small size allows close packing. wound healing via fibroblast glutathione synthesis support. anti-inflammatory via glycine-gated chloride channel activation (inhibitory neuromodulator).

Typically Found In: Skin conditioning products,wound healing,nmf moisturisers

TECHNICAL DETAILS

Primary Category: Active ingredient – simplest amino acid

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes – fermentation or synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Glycine's mandatory presence at every third position in collagen's triple helix (gly-x-y repeat) arises from its unique zero side-chain structure — only glycine is small enough to fit at the sterically restricted centre of the triple helix where the three polypeptide chains cross. no other amino acid can substitute for glycine in the collagen triple helix without disrupting the structure, making glycine irreplaceable in collagen biology.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides nmf conditioning with copper-chelating antioxidant and uv-absorbing activity from imidazole ring.

Why It's Used: Antioxidant nmf amino acid — histidine's imidazole ring provides unique copper-chelating antioxidant activity alongside nmf hydration and uv absorption not available from other nmf amino acids.

How It Works: Imidazole ring chelates cu²⁺ and fe²⁺ for antioxidant metal chelation (inhibiting fenton reaction). uv absorption at 211nm provides partial photoprotection. precursor for carnosine (with beta-alanine) for anti-glycation. nmf component via imidazole + carboxylate water binding.

Typically Found In: Antioxidant skincare,anti-aging products,nmf moisturisers

TECHNICAL DETAILS

Primary Category: Active ingredient – imidazole amino acid

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes – fermentation

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Histidine's imidazole ring's copper chelation provides the same chemical mechanism as the pharmaceutical cuprimine (d-penicillamine) used for copper chelation therapy in wilson's disease — just with significantly lower affinity. the imidazole copper chelation prevents fenton-type radical generation from free copper ions that would otherwise catalyse hydroxyl radical production from hydrogen peroxide.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides nmf conditioning with copper-chelating antioxidant and uv-absorbing activity from imidazole ring.

Why It's Used: Antioxidant nmf amino acid — histidine's imidazole ring provides unique copper-chelating antioxidant activity alongside nmf hydration and uv absorption not available from other nmf amino acids.

How It Works: Imidazole ring chelates cu²⁺ and fe²⁺ for antioxidant metal chelation (inhibiting fenton reaction). uv absorption at 211nm provides partial photoprotection. precursor for carnosine (with beta-alanine) for anti-glycation. nmf component via imidazole + carboxylate water binding.

Typically Found In: Antioxidant skincare,anti-aging products,nmf moisturisers

TECHNICAL DETAILS

Primary Category: Active ingredient – imidazole amino acid

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes – fermentation

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Histidine's imidazole ring's copper chelation provides the same chemical mechanism as the pharmaceutical cuprimine (d-penicillamine) used for copper chelation therapy in wilson's disease — just with significantly lower affinity. the imidazole copper chelation prevents fenton-type radical generation from free copper ions that would otherwise catalyse hydroxyl radical production from hydrogen peroxide.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Stimulates beta-defensin production in keratinocytes for innate antimicrobial defense while conditioning skin.

Why It's Used: Used in formulations combining skin conditioning with antimicrobial defense through keratinocyte defensin stimulation.

How It Works: Activates tlr2/tlr1 signaling in keratinocytes, upregulating beta-defensin-2 (hbd-2) and other antimicrobial peptides providing innate skin immune defense.

Typically Found In: Sensitive skin products,antimicrobial formulations,acne-prone formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – amino acid

Secondary Functions: Defensin stimulation,innate immunity support

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–3%

SOURCING & ETHICS

Vegan Status: Yes – plant-derived or synthetic

Halal Status: Yes

Source Notes: Fermentation-derived or synthetic. natural skin component.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; endogenous skin molecule.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. natural skin nmf component. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,peptides,other amino acids

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Isoleucine's stimulation of beta-defensin-2 via tlr1/2 signaling provides a unique antimicrobial mechanism where the amino acid activates the skin's own defensin production rather than directly killing bacteria – a more physiologically elegant approach to antimicrobial protection.

Last Verified: Cosing database,schauber et al. isoleucine defensin study

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Stimulates beta-defensin production in keratinocytes for innate antimicrobial defense while conditioning skin.

Why It's Used: Used in formulations combining skin conditioning with antimicrobial defense through keratinocyte defensin stimulation.

How It Works: Activates tlr2/tlr1 signaling in keratinocytes, upregulating beta-defensin-2 (hbd-2) and other antimicrobial peptides providing innate skin immune defense.

Typically Found In: Sensitive skin products,antimicrobial formulations,acne-prone formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – amino acid

Secondary Functions: Defensin stimulation,innate immunity support

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–3%

SOURCING & ETHICS

Vegan Status: Yes – plant-derived or synthetic

Halal Status: Yes

Source Notes: Fermentation-derived or synthetic. natural skin component.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; endogenous skin molecule.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. natural skin nmf component. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,peptides,other amino acids

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Isoleucine's stimulation of beta-defensin-2 via tlr1/2 signaling provides a unique antimicrobial mechanism where the amino acid activates the skin's own defensin production rather than directly killing bacteria – a more physiologically elegant approach to antimicrobial protection.

Last Verified: Cosing database,schauber et al. isoleucine defensin study

Primary Sources: 2026-03-12