Plix Pomegranate Overnight Repair Dewy Serum for Ageless Glow With Ceramides Reduce Fine Lines

DESCRIPTION

What It Does: Hyaluronic acid draws and locks moisture into the skin at multiple depths (surface and deeper layers depending on molecular weight), creating a plumping, smoothing, and hydrating effect.

Why It's Used: It is used because it is endogenous to human skin, making it exceptionally biocompatible and non-irritating. its unparalleled moisture-binding capacity makes it the most effective hydrating ingredient available.

How It Works: Ha binds water molecules through its many hydroxyl and carboxyl groups, creating a gel-like matrix. high molecular weight ha (>500 kda) hydrates the skin surface; low molecular weight ha (<50 kda) penetrates deeper to provide interior hydration.

Typically Found In: Serums,moisturizers,sheet masks,toners,eye creams,lip treatments,dermal fillers (injectable)

TECHNICAL DETAILS

Primary Category: Active ingredient – humectant/hydrator

Secondary Functions: Barrier repair,plumping,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2% (effective at very low concentrations; multi-weight ha provides superior results)

SOURCING & ETHICS

Vegan Status: Yes – biotechnology-derived (microbial fermentation of streptococcus equi or b. subtilis); vegan-certified versions widely available

Halal Status: Yes

Source Notes: Originally extracted from rooster combs; now predominantly produced via biotechnology (bacterial fermentation), which is vegan and more sustainable.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; one of the gentlest skincare ingredients known

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: In very dry environments, high-molecular-weight ha on the surface can potentially draw moisture out of the skin if not sealed with an occlusive. apply to damp skin and seal with moisturizer.

Safe for Sensitive Skin: Yes – ideal for all skin types including rosacea, eczema, and post-procedure skin

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. endogenous molecule – no toxicity concerns. ewg hazard score: 1. safe during pregnancy.

Works Well With: Virtually all ingredients; especially ceramides,glycerin,peptides,retinol (reduces irritation),niacinamide,vitamin c

Avoid Combining With: No significant incompatibilities; high concentrations of alcohol in a formula may reduce its efficacy

SCIENTIFIC NOTE

Hyaluronic acid naturally degrades in skin (half-life ~1–2 days). the skin produces it endogenously, but production decreases with age. multi-molecular-weight ha formulas provide hydration at both surface and deeper skin levels.

Last Verified: Cosing database,cir safety assessment,papakonstantinou et al. (2012) dermato-endocrinology

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides il-6-targeting anti-inflammaging activity as matrixyl 3000's immunomodulating component.

Why It's Used: Inflammaging-targeting peptide — palmitoyl tetrapeptide-7 targets the il-6-driven chronic skin inflammation (inflammaging) that accelerates collagen degradation in aging skin, providing anti-aging from a unique anti-inflammatory mechanism.

How It Works: Gqpr sequence mimics tuftsin (natural immunomodulating tetrapeptide). inhibits il-6 overproduction in aged fibroblasts and keratinocytes reducing chronic low-grade inflammatory mmp activation. stimulates ecm protein synthesis including collagen and fibronectin. used with palmitoyl oligopeptide as matrixyl 3000.

Typically Found In: Premium anti-aging serums,matrixyl 3000 products

TECHNICAL DETAILS

Primary Category: Active ingredient – signal peptide

Secondary Functions: Collagen stimulation,skin firming,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.0001%–0.01%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide

Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)

SCIENTIFIC NOTE

Matrixyl 3000's two-peptide combination (palmitoyl oligopeptide + palmitoyl tetrapeptide-7) targets aging from two complementary directions: palmitoyl oligopeptide stimulates collagen synthesis (anabolic anti-aging), while palmitoyl tetrapeptide-7 inhibits inflammaging-driven il-6 collagen destruction (catabolic anti-aging). together they provide a comprehensive two-pronged anti-aging approach.

Last Verified: Cosing database,sederma matrixyl 3000 technical data

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides certified olive-origin skin-identical hydrocarbon emolliency with highest natural credentials.

Why It's Used: Premium credentialled squalane — olive squalane provides the most prestigious and verifiable squalane provenance from traditional mediterranean olive heritage, essential for brands requiring the highest supply chain transparency and natural origin documentation.

How It Works: Identical molecular formula to other plant squalane (c30h62) — chemically indistinguishable. origin verified via carbon-14 isotope analysis or supply chain documentation. extracted from olive oil deodoriser distillate then hydrogenated. traditional mediterranean sourcing from certified olive mills.

Typically Found In: Premium mediterranean skincare,certified natural products,verified sustainable beauty

TECHNICAL DETAILS

Primary Category: Functional ingredient – emollient

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–100%

SOURCING & ETHICS

Vegan Status: Yes – certified from olea europaea (olive)

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 2026-01-05 00:00:00 -0800

Comedogenicity Rating: 0/5

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Olive squalane's origin verification via carbon-14 isotope dating (plant carbon has different ¹⁴c signature than petrochemical carbon which has no ¹⁴c from being geologically old) provides scientific authenticity validation — an absolute verification method distinguishing genuine plant-derived from petroleum-derived squalane that cannot be falsified by adulteration.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides punicalagin-based exceptional antioxidant activity with anti-inflammatory and skin regeneration benefits.

Why It's Used: Highest-orac common fruit extract – punicalagins provide unmatched antioxidant activity alongside oestrogenic urolithins for anti-aging and barrier support.

How It Works: Punicalagins a and b (2x the antioxidant power of red wine) provide orac value ~10,000 μmol te/g. metabolized to urolithins by skin microbiome – urolithin a activates mitophagy for cellular anti-aging. ellagic acid inhibits tyrosinase for brightening. mild estrogenic activity via urolithin phytoestrogens.

Typically Found In: Premium antioxidant products,brightening formulas,anti-aging serums

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Punicalagin orac,urolithin mitophagy

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Yes – from punica granatum fruit

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Pomegranate punicalagin's conversion to urolithin a by skin microbiome represents a remarkable prebiotic-probiotic relationship: the skin's resident bacteria metabolize the polyphenol precursor to create the bioactive urolithin that activates mitophagy (cellular mitochondrial quality control). this microbiome-dependent bioactivation means the same punicalagin extract has different anti-aging potency across individuals depending on their microbiome composition.

Last Verified: Cosing database,seeram et al. pomegranate punicalagin review

Primary Sources: 2026-03-12