Neutrogena
On-the-Spot® Acne Treatment
On-the-Spot® Acne Treatment
Neutrogena
on-the-spot-r-acne-treatment
Moisturize
9818399899941
Morning or Evening?
How often will you use this product?
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Highlights
WHAT IS IT?
Acne spot treatment with 2.5% Benzoyl Peroxide
FEATURES
Lightweight formula, Quick absorption, Deep pore penetration, Non-drying, Non-irritating
BEST FOR
oily, dry, acne-prone
CHECKS
Free of alcohol, paraben, sulfate, silicon, oil, fragrance
Who Is It For?
Teens And Adults With Acne-prone SkinWhat Does It Help With?
Treats Acne Kills Acne Bacteria Prevents New BreakoutsBudget
Affordable (under $30)How To Use
Which routine should it be used in?
Instructions:
Key Information
What Neutrogena Says
Product Description:
A fast-acting acne spot treatment containing 2.5% Benzoyl Peroxide that starts clearing skin on day 1 without over-drying, stinging or burning. It quickly absorbs into skin and goes deep down to the pores to kill acne bacteria.
About the Brand:
Ingredients Overview
Ingredients List
Water, Carbomer Homopolymer Type B, Ethylhexylglycerin, Sodium Hydroxide, Chlorphenesin, Disodium Edta, Laureth-4, Hydroxypropyl Methylcellulose
Key Ingredients
Benzoyl Peroxide
Ingredients Details
Benzoyl Peroxide
Common Name(s): Benzoyl peroxide,cosmetic active,functional ingredient
CAS Number: N/a
DESCRIPTION
What It Does: Delivers characteristic cosmetic function — skin conditioning, protection, preservation, or active biological benefit — at recommended use concentration.
Why It's Used: Selected for its functional contribution and formulation compatibility — supported by cosmetic science literature and regulatory safety assessment.
How It Works: Works through the mechanism of its molecular class — physicochemical interaction with the formulation or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed literature.
Typically Found In: Skin care formulations
TECHNICAL DETAILS
Primary Category: Active ingredient – cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–10%
SOURCING & ETHICS
Vegan Status: Conditional
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Benzoyl peroxide delivers documented functional benefit with an established safety profile within the cosmetic regulatory framework (cosing eu, cir usa).
Last Verified: Cosing database,benzoyl peroxide technical literature
Primary Sources: 2026-03-12
Chlorphenesin
Common Name(s): 3-(4-chlorophenoxy)-1,2-propanediol,globacid
CAS Number: 104-29-0
DESCRIPTION
What It Does: Provides gram-negative focused preservation complementary to phenoxyethanol for comprehensive spectrum coverage.
Why It's Used: Phenoxyethanol complement — chlorphenesin's gram-negative and antifungal coverage complements phenoxyethanol's gram-positive activity for full-spectrum preservation at lower individual concentrations.
How It Works: 4-chlorophenol ether glycol disrupts bacterial and fungal membranes. strong gram-negative activity (pseudomonas, e. coli). good candida antifungal activity. used with phenoxyethanol for synergistic broad-spectrum coverage. ph stable 3-9.
Typically Found In: Comprehensive preservation systems,baby products (low concentration)
TECHNICAL DETAILS
Primary Category: Functional ingredient – glycerol ether preservative
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–0.3%
SOURCING & ETHICS
Vegan Status: Yes – synthetic
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Eu max 0.3% cosmetics. good safety profile. synergistic combination with phenoxyethanol (0.3% pe + 0.1% chlorphenesin often equivalent to 1% pe alone).
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Chlorphenesin + phenoxyethanol synergy operates through a classic spectrum-filling combination: phenoxyethanol provides strong gram-positive antimicrobial activity while chlorphenesin provides gram-negative and antifungal coverage. the combination's minimum inhibitory concentration sum is subadditive (provides equivalent preservation at combined concentrations below what either alone would require) — textbook pharmacological synergy enabling lower total preservative load.
Last Verified: Cosing database,eu preservative annex v,cir safety assessment
Primary Sources: 2026-03-12
Disodium Edta
Common Name(s): Edathamil disodium,edta disodium,versene 100
CAS Number: 139-33-3
DESCRIPTION
What It Does: Provides metal ion chelation to prevent product degradation and boost preservative and antioxidant efficacy.
Why It's Used: The most essential stability ingredient in cosmetics — disodium edta's metal chelation prevents rancidity, discoloration, and preservative failure caused by trace metal contamination in virtually all aqueous cosmetic formulations.
How It Works: Ethylenediaminetetraacetic acid provides six potential coordination sites for metal ions (aminodiacetate groups). chelates ca²⁺, mg²⁺ (stability), fe³⁺ (fenton radical prevention), cu²⁺ (oxidase inhibition). disrupts gram-negative bacterial outer membrane by chelating membrane calcium, enhancing preservative penetration.
Typically Found In: Virtually all aqueous cosmetics — creams, lotions, shampoos, toners
TECHNICAL DETAILS
Primary Category: Functional ingredient – chelating agent
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.005%–0.1%
SOURCING & ETHICS
Vegan Status: Yes – synthetic
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Disodium edta's preservative potentiation against gram-negative bacteria is mechanistically elegant: gram-negative outer membranes contain lipopolysaccharide stabilised by calcium and magnesium bridges. edta chelates these metal ions, destabilising the lps layer and creating pores that allow hydrophobic preservatives (phenoxyethanol, parabens) to penetrate — converting gram-negative-resistant preservatives into broad-spectrum ones.
Last Verified: Cosing database,cir safety assessment
Primary Sources: 2026-03-12
Ethylhexylglycerin
Common Name(s): Octylglycerin,2-ethylhexyl glycerol ether,sensiva sc 10
CAS Number: 70445-33-9
DESCRIPTION
What It Does: Provides antimicrobial skin conditioning with deodorant activity and preservation system enhancement.
Why It's Used: Multifunctional clean beauty preservation active — ethylhexylglycerin provides antimicrobial, deodorant, and skin conditioning in a single ingredient accepted in most natural cosmetic certification schemes.
How It Works: Glycerol ether provides antimicrobial via bacterial membrane phospholipid disruption. deodorant activity via reduction of underarm lipase enzyme activity (similar mechanism to triethyl citrate). skin conditioning from glycerol humectant component. synergistic with phenoxyethanol and diols.
Typically Found In: Natural preservation systems,deodorants,skin conditioning products
TECHNICAL DETAILS
Primary Category: Functional ingredient – antimicrobial glycerol ether
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–0.5%
SOURCING & ETHICS
Vegan Status: Yes – synthetic
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Ethylhexylglycerin's deodorant mechanism is pharmacologically identical to triethyl citrate: both inhibit skin surface microbial lipase enzymes that convert odourless triglycerides to odorous free fatty acids. the glycerol ether structure of ethylhexylglycerin, combined with the 2-ethylhexyl chain, provides lipase inhibition similar to ester-based lipase inhibitors from a different chemical class.
Last Verified: Cosing database,schülke sensiva sc 10 technical data,cir safety assessment
Primary Sources: 2026-03-12