LANEIGE Radian-C Cream

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

1-2-hexanediol has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,1-2-hexanediol technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the defining intense lemon-citrus fragrance note.

Why It's Used: The lemon scent compound – citral defines the fresh lemon scent in lemon essential oil and lemongrass with potent antimicrobial activity.

How It Works: Mixture of e-isomer (geranial) and z-isomer (neral). antimicrobial via michael addition to thiol enzymes. inhibits nf-kb for anti-inflammatory activity. antioxidant via allylic aldehyde.

Typically Found In: Citrus fragrances,antibacterial products,lemon-scented cosmetics

TECHNICAL DETAILS

Primary Category: Fragrance component – lemon aldehyde

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.001%–0.5%

SOURCING & ETHICS

Vegan Status: Yes – from lemon, lemongrass, melissa oils

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Eu cosmetics regulation: declared fragrance allergen. high sensitisation potential from alpha,beta-unsaturated aldehyde structure. ifra strict limits.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Citral's high sensitisation potential (llna ec3 ~0.11%) is a consequence of its alpha,beta-unsaturated aldehyde structure providing a highly reactive michael acceptor for skin protein covalent binding. the e/z mixture (geranial/neral) in natural citral means both isomers contribute to the sensitisation burden – explaining why lemongrass oil (very high citral content, ~60-80%) is one of the more common essential oil allergens.

Last Verified: Cosing database,ifra standards

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antimicrobial skin conditioning with deodorant activity and preservation system enhancement.

Why It's Used: Multifunctional clean beauty preservation active — ethylhexylglycerin provides antimicrobial, deodorant, and skin conditioning in a single ingredient accepted in most natural cosmetic certification schemes.

How It Works: Glycerol ether provides antimicrobial via bacterial membrane phospholipid disruption. deodorant activity via reduction of underarm lipase enzyme activity (similar mechanism to triethyl citrate). skin conditioning from glycerol humectant component. synergistic with phenoxyethanol and diols.

Typically Found In: Natural preservation systems,deodorants,skin conditioning products

TECHNICAL DETAILS

Primary Category: Functional ingredient – antimicrobial glycerol ether

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–0.5%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Ethylhexylglycerin's deodorant mechanism is pharmacologically identical to triethyl citrate: both inhibit skin surface microbial lipase enzymes that convert odourless triglycerides to odorous free fatty acids. the glycerol ether structure of ethylhexylglycerin, combined with the 2-ethylhexyl chain, provides lipase inhibition similar to ester-based lipase inhibitors from a different chemical class.

Last Verified: Cosing database,schülke sensiva sc 10 technical data,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides fresh rose-geranium floral scent with antimicrobial activity.

Why It's Used: The rose fragrance terpene – geraniol defines the fresh, sweet rose-geranium note found in more than 60 essential oils and is essential for recreating natural floral fragrance profiles.

How It Works: Monoterpene alcohol inhibits bacterial membrane integrity for antimicrobial activity. activates trpv1 for anti-nociception. inhibits nf-kb for anti-inflammatory activity. antioxidant via allylic radical scavenging.

Typically Found In: Rose-scented products,floral fragrances,natural cosmetics

TECHNICAL DETAILS

Primary Category: Fragrance component – acyclic monoterpene alcohol

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.001%–1%

SOURCING & ETHICS

Vegan Status: Yes – from rose, geranium, palmarosa oils

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Eu cosmetics regulation: declared fragrance allergen. ifra guidelines apply.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Geraniol's isomers (geraniol, nerol, citronellol) provide subtly different scent characters despite identical molecular formulae (c10h18o): geraniol provides the sweet, fresh rose note while its z-isomer nerol has a more delicate, neroli-like character. these isomeric scent differences arise from different spatial presentation of the hydroxyl and double bond groups to the olfactory receptor – demonstrating the extraordinary structural sensitivity of olfactory perception.

Last Verified: Cosing database,ifra standards

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.

Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.

How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.

Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners

TECHNICAL DETAILS

Primary Category: Humectant

Secondary Functions: Skin barrier support,emollient,solvent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–30% (typical: 3–10%)

SOURCING & ETHICS

Vegan Status: Yes – plant-derived (coconut, soy, palm) or synthetic

Halal Status: Yes – when plant-derived or synthetic; verify source with supplier

Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; non-irritating at all standard concentrations

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).

Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas

Avoid Combining With: No known incompatibilities at standard concentrations

SCIENTIFIC NOTE

Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the defining fresh citrus fragrance note alongside solvent and antimicrobial properties.

Why It's Used: The citrus industry's primary fragrance compound and the most abundant terpene in essential oils – limonene provides the clean, universally appealing fresh citrus scent character.

How It Works: D-limonene activates trpv1 mildly at high concentrations. antimicrobial via membrane disruption. solvent for oils and lipophilic compounds. cleaning via emulsification of lipid soils.

Typically Found In: Citrus-scented products,cleaning products,fragrance compounds

TECHNICAL DETAILS

Primary Category: Fragrance component – cyclic monoterpene

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.001%–3%

SOURCING & ETHICS

Vegan Status: Yes – from citrus peel essential oils

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Eu cosmetics regulation: declared fragrance allergen. oxidises to sensitising compounds (limonene hydroperoxides) on air exposure – use with antioxidant stabilisers. ifra guidelines apply.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Limonene's sensitisation risk arises not from limonene itself but from its autooxidation products (limonene-1,2-epoxide and limonene hydroperoxides) formed on air exposure. fresh limonene has low sensitisation potential, but air-oxidised limonene's hydroperoxide products are potent skin sensitisers. this explains why oxidation-stabilised formulations (with bht or other antioxidants) are required to manage limonene safety.

Last Verified: Cosing database,ifra standards,bråred christensson et al. limonene oxidation study

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the most common natural floral-citrus fragrance note with additional anti-inflammatory properties.

Why It's Used: The most abundant fragrance terpene in nature – linalool forms the primary scent character of lavender, responsible for lavender's documented aromatherapy calming effects.

How It Works: Monoterpene alcohol activates gaba-a receptors for anti-anxiety activity (same receptor as benzodiazepines). inhibits glutamate-induced excitotoxicity. antimicrobial via membrane disruption. anti-inflammatory via nf-kb inhibition.

Typically Found In: Virtually all fragranced cosmetics

TECHNICAL DETAILS

Primary Category: Fragrance component – tertiary terpene alcohol

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.001%–3%

SOURCING & ETHICS

Vegan Status: Yes – from lavender, coriander, bergamot

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Eu cosmetics regulation: declared fragrance allergen on label when >0.001% (leave-on) or >0.01% (rinse-off). ifra guidelines apply.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Linalool's gaba-a receptor activation provides a pharmacological basis for lavender aromatherapy's documented anxiolytic effects. the same receptor modulation used by benzodiazepine drugs (such as diazepam) is activated by inhaled linalool vapor, providing receptor-mediated calming without the tolerance and dependence associated with pharmaceutical gaba-a modulators.

Last Verified: Cosing database,ifra standards,elisabetsky et al. linalool gaba study

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Stimulates collagen synthesis and wound healing while reducing inflammation – the primary active in centella asiatica's skin repair activity.

Why It's Used: Standardized centella active for precise wound healing, collagen stimulation, and anti-inflammatory dosing with superior consistency vs whole centella extract.

How It Works: Activates tgf-beta1 receptor signaling to upregulate collagen i, iii, and iv synthesis in fibroblasts. inhibits nf-kb for anti-inflammatory activity. promotes keratinocyte migration and proliferation for re-epithelialization. also strengthens lamellar body structures.

Typically Found In: Post-procedure recovery,wound healing serums,anti-aging products,sensitive skin formulas

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Collagen stimulation,wound healing,anti-inflammatory

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%–2%

SOURCING & ETHICS

Vegan Status: Yes – from centella asiatica

Halal Status: Yes

Source Notes: Extracted from centella asiatica aerial parts. standardized to madecassoside content for consistent bioactivity.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Madecassoside is the most water-soluble and bioavailable of the four major centella triterpene glycosides. its tgf-beta1-mediated collagen stimulation distinguishes it from other soothing actives – providing not just anti-inflammatory relief but active tissue remodeling and collagen neosynthesis.

Last Verified: Cosing database,bylka et al. centella review,liu et al. madecassoside collagen study

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides humectant and solvent functionality from sustainable corn-based fermentation.

Why It's Used: Bio-based propylene glycol alternative from renewable corn — propanediol provides equivalent functionality to propylene glycol with sustainable renewable feedstock and superior skin feel.

How It Works: Two oh groups provide humectant water binding. excellent solvent for fragrances, actives, and preservatives. mild antimicrobial from diol structure for preservative system boosting. renew corn fermentation origin (dupont zemea process). better skin feel than propylene glycol — less sticky.

Typically Found In: Virtually all cosmetic categories as pg alternative

TECHNICAL DETAILS

Primary Category: Functional ingredient – humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–20%

SOURCING & ETHICS

Vegan Status: Yes – from corn sugar fermentation

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Propanediol's dupont tate & lyle bio products 'zemea' process ferments corn sugar to 1,3-propanediol using engineered e. coli — one of the first commercially viable bio-fermentation routes to a cosmetic diol previously made only from petroleum. the renewable route produces chemically identical 1,3-propanediol while reducing carbon footprint by approximately 40% vs petrochemical synthesis.

Last Verified: Cosing database,dupont tate & lyle zemea technical data,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Tocopherol neutralizes free radicals that damage skin cells, protects cell membranes from lipid peroxidation, moisturizes, and helps maintain a healthy skin barrier.

Why It's Used: It is used as both a skin-active antioxidant and a formulation stabilizer (preventing oxidation of other ingredients). it has decades of safety and efficacy evidence and works synergistically with vitamin c.

How It Works: As a chain-breaking antioxidant, tocopherol donates hydrogen atoms to interrupt lipid peroxidation chain reactions. it is regenerated by vitamin c (ascorbic acid) in the vitamins c+e antioxidant cycle, creating a more durable antioxidant defense.

Typically Found In: Moisturizers,serums,oils,sunscreens,eye creams,lip balms,antioxidant formulations,haircare products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant/vitamin e

Secondary Functions: Emollient,formulation stabilizer,barrier support

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–1% (typical: 0.1–0.5% as active; higher as formulation antioxidant)

SOURCING & ETHICS

Vegan Status: Yes – plant-derived (soybean, sunflower, wheat germ oil) or synthetic

Halal Status: Yes – plant-derived or synthetic

Source Notes: Natural d-alpha-tocopherol is derived from plant oils and is more bioactive. synthetic dl-alpha-tocopherol is less expensive. tocopherol acetate (tocopheryl acetate) is the more stable ester form.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; rare contact sensitivity reported

Comedogenicity Rating: 2/5 – mildly comedogenic at higher concentrations; formulation-dependent

Sensitivity Concerns: A small percentage of people report contact sensitization to tocopherol, particularly with leave-on products. comedogenicity risk is higher in oil-heavy formulations.

Safe for Sensitive Skin: Generally yes; perform patch test if history of vitamin e sensitivity

SAFETY & COMPATIBILITY

Safety Profile: Very safe; widely used. ewg hazard score: 2–3 (depending on concentration). no significant systemic concerns from topical use.

Works Well With: Ascorbic acid (vitamin c) – synergistic antioxidant pair,ferulic acid – stabilizes and boosts both c and e,ceramides,spf,retinol

Avoid Combining With: Very high concentrations of benzoyl peroxide may oxidize tocopherol; potential comedogenicity concerns in acne-prone skin when in heavy oil bases

SCIENTIFIC NOTE

The combination of vitamin c, vitamin e, and ferulic acid (the 'ce ferulic' formulation) provides fourfold photoprotection against uv-induced free radical damage – a synergy documented in landmark research by pinnell et al.

Last Verified: Cosing database,cir safety assessment,pinnell et al. (2005) journal of investigative dermatology,efsa panel on food additives

Primary Sources: 2026-03-12