
Highlights
WHAT IS IT?
Face Serum with peptide-firming complex, 3 key ingredients
FEATURES
Non-Toxic Botox Alternative, Peptide Firming Complex, Stimulates Collagen Production, Hydration Retention
BEST FOR
sensitive
CHECKS
No injections, non-toxic, safe for sensitivity to Botox
Who Is It For?
Adults All GendersWhat Does It Help With?
Reducing Fine Lines And Wrinkles Improving Skin Firmness Photoaging Protection Collagen Stimulation Hydration RetentionBudget
Mid-range ($30-$75)How To Use
Which routine should it be used in?
Instructions:
Key Information
What Nykaa E retail limited Says
Product Description:
Experience the power of IRWINGS ACE SERUM, a non-toxic alternative to Botoxtherapy designed to reduce dynamic lines and improve skin firmness. This innovativepeptide-firming serum features a potent Argireline complex (Acetyl Hexapeptide-8)that mimics the effects of botulinum toxin, effectively obliterating expressionwrinkles and fine lines. This serum not only targets expression wrinkles but also offers protection against photoaging. It stimulates collagen production, helping your skin retain hydration and promoting a smoother, more youthful appearance. IRWINGS ACE SERUM is perfect for those with sensitivity to Botox or intolerance to its side effects. Its lightweight texture ensures quick absorption, making it suitable for use both in the morning and at night. Simply apply 3-4 drops on a clean, damp face, massaging the serum into the skin with extra focus on areas of concern like forehead lines, crow feet, and laugh lines.
About the Brand:
Ingredients Overview
Ingredients List
Hexapeptide-8,Argireline,Vitamin-C
Key Ingredients
Hexapeptide-8,Argireline,Vitamin-C
Ingredients Details
Argireline
Common Name(s): Argireline,acetyl hexapeptide-8,snap-25 fragment
CAS Number: 616204-22-9
DESCRIPTION
What It Does: Provides snare complex competitive inhibition for expression line and dynamic wrinkle reduction.
Why It's Used: The original and most studied neurocosmetic peptide โ argireline pioneered the snare inhibitor class with the most clinical study data of any expression line reducing peptide.
How It Works: 6-residue n-terminal snap-25 mimetic competitively inhibits snare complex assembly. reduced snare complex formation โ reduced vesicle fusion โ reduced acetylcholine exocytosis at neuromuscular junction โ reduced muscle contraction force โ reduced expression line depth.
Typically Found In: Expression line products,anti-wrinkle serums,neurocosmetic products
TECHNICAL DETAILS
Primary Category: Active ingredient โ signal peptide
Secondary Functions: Collagen stimulation,skin firming,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.0001%โ0.1%
SOURCING & ETHICS
Vegan Status: Yes โ synthetic
Halal Status: Yes
Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for all skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Exceptional safety profile. ewg score: 1.
Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide
Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)
SCIENTIFIC NOTE
Argireline's snare mechanism was validated by blanes-mira et al. (2002) in the first published characterisation of a cosmetic snare inhibitor, demonstrating acetyl hexapeptide-3 reduced acetylcholine release at neuromuscular junctions in cell models by ~21% at 10ฮผg/ml โ establishing the pharmacological basis for all subsequent neurocosmetic snare peptides.
Last Verified: Cosing database,blanes-mira et al. argireline snare study
Primary Sources: 2026-03-12
Hexapeptide-8
Common Name(s): Hexapeptide-8,hexapeptide-8,six-residue signal peptide,anti-aging collagen active
CAS Number: N/a
DESCRIPTION
What It Does: Stimulates fibroblast collagen i, iii, iv synthesis and inhibits mmp-1 collagen degradation โ providing clinically measurable wrinkle reduction and skin firmness at 1โ5000 ppm.
Why It's Used: Six and seven-residue peptides provide the optimal sequence length-activity balance โ long enough for full receptor docking geometry, short enough for sc penetration without lipid anchoring (with exceptions for palmitoyl-anchored forms).
How It Works: Peptide receptor binding โ map kinase or smad cascade โ col1a1/col3a1 upregulation + mmp-1/mmp-3 inhibition. spps synthesis provides >98% sequence purity for reproducible pharmacological response.
Typically Found In: Anti-aging serums,collagen products
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1โ5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Hexapeptide/heptapeptide inci numbering follows cosing registry sequence assignment โ each number designates a unique amino acid sequence targeting different receptor subtypes for complementary anti-aging mechanisms. hexapeptide-8 (argireline) is the benchmark acetyl hexapeptide for achr-mediated expression-line reduction.
Last Verified: Cosing database,hexapeptide-8 signal peptide anti-aging review
Primary Sources: 2026-03-22