INATUR RETINOL NIGHT CREAM - ANTI AGING, BRIGHTENING, DEEP HYDRATION, WITH BAKUCHIOL & SOYA PEPTIDES

DESCRIPTION

What It Does: Soothes irritation, accelerates wound healing, promotes skin cell renewal, and provides mild keratolytic exfoliation.

Why It's Used: Gold standard multi-function soothing active – one of the most widely used cosmetic ingredients across all product types for its exceptional tolerability and clinically proven multi-action skin conditioning.

How It Works: Promotes keratinocyte proliferation and fibroblast migration for wound healing. mild keratolytic activity by disrupting corneocyte binding. anti-irritant via direct protein binding and anti-inflammatory cytokine reduction. humectant activity via hydroxyl groups.

Typically Found In: Post-procedure products,sensitive skin formulas,wound care,anti-acne treatments,baby products

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Wound healing,keratolytic,anti-irritant

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – synthetic or comfrey-derived

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Exceptionally well-tolerated; suitable for all skin types including baby and compromised skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Allantoin's keratinocyte proliferation stimulation occurs via receptor-mediated signaling (possibly machr activation) rather than non-specific irritation-driven proliferation, making it a true wound-healing stimulant rather than a pro-inflammatory proliferative signal.

Last Verified: Cosing database,cir safety assessment,araújo et al. allantoin review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides retinol-equivalent anti-aging gene expression from a natural plant compound without retinol's limitations.

Why It's Used: The natural retinol alternative — the first plant compound with rct evidence for equivalent anti-aging results to retinol with better safety and photostability.

How It Works: Bakuchiol activates rar beta and retinoid x receptors via allosteric binding mechanism. upregulates type i, iii, and iv collagen synthesis genes. downregulates mmp-1 and mmp-9. antioxidant via phenol radical scavenging. photostable — stable to uv exposure unlike retinol.

Typically Found In: Natural anti-aging serums,pregnancy-safe retinol alternative,photostable anti-aging

TECHNICAL DETAILS

Primary Category: Active ingredient – natural retinol alternative

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–2%

SOURCING & ETHICS

Vegan Status: Yes – from psoralea corylifolia seeds

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

The dhaliwal et al. (2019, british journal of dermatology) split-face rct directly compared 0.5% bakuchiol vs 0.5% retinol twice daily for 12 weeks — both groups showed equivalent reduction in fine lines and wrinkles, but bakuchiol showed significantly less scaling, stinging, and burning. this is the strongest evidence that bakuchiol provides retinol-equivalent anti-aging with better tolerability.

Last Verified: Cosing database,dhaliwal et al. bakuchiol vs retinol rct

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides humectant hydration and active ingredient solubilization with excellent skin feel.

Why It's Used: Preferred glycol humectant in premium and k-beauty formulations for superior skin feel vs propylene glycol with equivalent functionality.

How It Works: Two hydroxyl groups at 1,3-positions provide water binding and solvent activity. better tolerated than propylene glycol with minimal sensitization risk. 4-carbon backbone provides slightly greater hydrophobic character enabling dissolution of less polar actives vs pg.

Typically Found In: Toners,essences,serums,k-beauty formulas

TECHNICAL DETAILS

Primary Category: Functional ingredient – glycol humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–10%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

K-beauty's preference for butylene glycol over propylene glycol is driven by two factors: bg's superior skin feel (less tacky than pg's higher viscosity) and its lower sensitization potential (1,3-bg has better spatial distribution of hydroxyl groups that reduces protein interaction vs pg's 1,2-position oh groups).

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Forms a transparent, flexible film on skin within minutes of application that physically tightens surface texture and reduces the appearance of pores and fine lines — providing the visible 'instant lifting' effect used in eye creams and prestige anti-aging serums.

Why It's Used: Pullulan provides the immediate visible lifting effect that biological actives (peptides, retinoids) require weeks to produce — enabling 'instant + long-term' positioning where the pullulan film delivers the immediate visual result while slower actives provide the cumulative benefit.

How It Works: Pullulan film forms by water evaporation after application — the polysaccharide chains entangle and h-bond forming a cohesive biopolymer network on the skin surface. the film's tensile strength provides physical compression of superficial wrinkles and pores. the film is water-resistant (resists perspiration) but fully biodegradable from the natural polysaccharide structure.

Typically Found In: Eye creams,anti-aging prestige serums,instant effect

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Pullulan film tensile properties: young's modulus ~1.5 gpa dry — sufficient for physical skin surface compression and tightening perception. the film softens progressively through the day as skin moisture is absorbed, providing a self-regulating wear-down that matches skin dynamics.

Last Verified: Cosing database,pullulan instant film-forming lifting review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Retinol accelerates skin cell turnover, stimulates collagen production, reduces fine lines and wrinkles, fades hyperpigmentation, and helps normalize pore size.

Why It's Used: It is the most evidence-backed anti-aging ingredient available without a prescription. it provides comprehensive skin renewal benefits that no other single cosmetic ingredient can match.

How It Works: Retinol is converted in the skin to retinoic acid, which binds to retinoid receptors in cell nuclei. this activates gene expression changes that accelerate cell turnover, boost collagen synthesis, and inhibit matrix metalloproteinases (collagen-degrading enzymes).

Typically Found In: Night creams,serums,eye creams,targeted treatment products,anti-aging formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – vitamin a derivative

Secondary Functions: Exfoliating,anti-acne,brightening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.025%–1% (otc); start at low concentrations and build up slowly

SOURCING & ETHICS

Vegan Status: Conditional – can be animal-derived (fish liver, egg yolk) or synthetic; verify source

Halal Status: Conditional – verify source; synthetic retinol is halal

Source Notes: Cosmetic retinol is predominantly synthetically manufactured. some natural sources include fish liver oils. synthetic is preferred for purity and sustainability.

SKIN COMPATIBILITY

Irritancy Rating: 3/5 – moderate; can cause dryness, peeling, redness, especially during adjustment period (retinization)

Comedogenicity Rating: 0/5 – non-comedogenic; actually helps clear pores

Sensitivity Concerns: Retinization period: 2–6 weeks of potential dryness, flaking, and sensitivity. photosensitizing – must use spf when using retinol. avoid during pregnancy.

Safe for Sensitive Skin: Use with caution – start at 0.025%, buffer with moisturizer, use every 2–3 nights initially

SAFETY & COMPATIBILITY

Safety Profile: Safe for general use at otc concentrations. not recommended during pregnancy. avoid with waxing. use spf daily. ewg hazard score: varies by concentration.

Works Well With: Niacinamide (soothes irritation),peptides,ceramides,hyaluronic acid,spf (mandatory)

Avoid Combining With: Benzoyl peroxide (may inactivate retinol),ahas/bhas (when new to retinol – overexfoliation risk),vitamin c (use at different times)

SCIENTIFIC NOTE

Retinol is approximately 20 times less potent than prescription tretinoin (retinoic acid) but significantly better tolerated. the conversion rate of retinol to retinoic acid in skin is the rate-limiting step in its efficacy.

Last Verified: Cosing database,cir safety assessment,journal of investigative dermatology,kligman et al. studies

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the characteristic cosmetic function of its ingredient class through its molecular chemistry at recommended use concentration.

Why It's Used: Sodium glutamate is selected for the specific functional properties of its molecular class — the chemical architecture of sodium glutamate delivers the required cosmetic performance through documented interactions with skin biology and formulation matrix.

How It Works: The functional groups interact with formulation components and skin surfaces through h-bonding, ionic association, surface adsorption, or receptor activity as appropriate to the molecular class.

Typically Found In: Cosmetic formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Safety documented in cosing and cosmetic chemistry literature at standard formulation concentrations.

Last Verified: Cosing database,sodium glutamate technical review

Primary Sources: 2026-03-22

DESCRIPTION

What It Does: Provides hyaluronic acid hydration in the most formulation-stable and compatible form.

Why It's Used: The standard form of ha used in cosmetics – more stable than free ha, better solubility, and equivalent skin hydration benefits.

How It Works: Sodium salt reduces the polyelectrolyte repulsion of ha chains, allowing better packing in formulations. on skin, sodium ions dissociate and the ha chain unfolds to its full water-binding conformation. provides full ha humectant and barrier benefits equivalent to free ha.

Typically Found In: Hydrating serums,toners,moisturizers,sheet masks,anti-aging products

TECHNICAL DETAILS

Primary Category: Active ingredient – ha sodium salt

Secondary Functions: Equivalent ha hydration,superior stability

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes – bacterial fermentation

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

The sodium salt form of ha has approximately 10% better water solubility than free hyaluronic acid at equivalent molecular weight due to reduced chain-chain electrostatic repulsion from partial sodium counterion screening. this improved solubility enables higher concentration formulations without viscosity issues.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Quenches lipid peroxyl radicals (loo•) in the sc lipid phase preventing lipid peroxidation chain reactions, stabilises co-formulated vitamin c through radical recycling synergy, and conditions skin with emollient tocopherol character.

Why It's Used: The primary lipid-phase antioxidant in human skin — essential for protecting sc lipid bilayers from uv-induced peroxidation that is not accessible to water-soluble antioxidants, and uniquely synergistic with vitamin c which regenerates oxidised vitamin e.

How It Works: Tocopherol donates h• to lipid peroxyl radicals (loo• + phoh → looh + pho•); the resulting tocopheroxyl radical (pho•) is reduced back to tocopherol by ascorbate — providing catalytic antioxidant activity. ester forms (acetate, succinate) require sc esterases for hydrolysis to active tocopherol.

Typically Found In: Antioxidant formulas,vitamin c serums,moisturisers

TECHNICAL DETAILS

Primary Category: Active ingredient – vitamin e derivative

Secondary Functions: Formulation stabilizer,emollient

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived (soy, sunflower) or synthetic. requires antioxidant stabilization.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – very low

Sensitivity Concerns: Rare contact sensitization; generally very well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ascorbic acid,ferulic acid,ceramides,spf

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Tocopherol's lipophilicity (logp ~10) restricts it to the lipid phase of the sc — exactly where lipid peroxidation chain reactions from uv exposure occur. this phase-specific targeting makes vitamin e uniquely effective at preventing the lipid oxidation that drives photoaging.

Last Verified: Cosing database,vitamin e tocopherol lipid antioxidant review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides the universal solvent and vehicle for water-soluble actives and the continuous phase of all o/w emulsions.

Why It's Used: The most essential cosmetic ingredient — aqua (water) is listed first on virtually all water-containing cosmetic inci labels as the highest-concentration ingredient, serving as the foundation of the global cosmetics industry.

How It Works: Acts as solvent for all water-soluble ingredients (glycols, amino acids, water-soluble actives). forms the continuous external phase of o/w emulsions (lotions, creams, serums). provides aqueous environment for enzymatic and chemical reactions between actives. ph adjustment medium.

Typically Found In: Virtually all cosmetic products — the most universal cosmetic ingredient globally

TECHNICAL DETAILS

Primary Category: Functional ingredient – water

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: Varies widely — up to 95% in some toners and serums

SOURCING & ETHICS

Vegan Status: Yes – water (deionised/purified)

Halal Status: Yes

Source Notes: Cosmetic-grade water is purified (deionised, distilled, or ro filtered) to prevent mineral content interference with formulation stability. european pharmacopoeial water (aqua purificata ph. eur.) is the quality standard for pharmaceutical and high-end cosmetic formulations.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – non-irritant

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Water's position as the first inci ingredient on most cosmetic labels reflects the regulatory requirement to list ingredients in descending concentration order — meaning water is the most abundant ingredient in the majority of cosmetic products. the fundamental role of water as the universal cosmetic solvent and vehicle makes it simultaneously the most important cosmetic ingredient and the one that requires the most sophisticated formulation chemistry to control — every emulsifier, thickener, preservative, and ph adjuster exists primarily to manage water's interaction with other ingredients in formulation.

Last Verified: Cosing database,eu cosmetics regulation 1223/2009 inci requirements,ph. eur. aqua purificata monograph

Primary Sources: 2026-03-12