High Potency Classics Nutritive Cleanser

Perricone MD

High Potency Classics Nutritive Cleanser

High Potency Classics Nutritive Cleanser

Perricone MD

high-potency-classics-nutritive-cleanser

Cleanse

9643621843237

Morning or Evening?

Morning
Evening
Both

How often will you use this product?

Everyday
Every other day
Every 3 days
Every 4 days
Every 5 days
Every 6 days
Once a week
Twice a week
On specific days
As needed
On rotation

Notes

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Compatibility Score

0%

Microbiome
Ingredients
Biological
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How It Fits Into Your Skincare Routine

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Highlights

WHAT IS IT?

Gel cleanser

FEATURES

Non-drying, skin softening and conditioning

BEST FOR

Normal to dry skin

CHECKS

Free from soy, gluten, fish, milk, phthalates, parabens, talc, and mineral oil

Who Is It For?

Adults (men And Women)

What Does It Help With?

Removes Excess Oil Debris And Impurity Buildup

Budget

Mid-range

How To Use

Which routine should it be used in?

Morning
Evening
 
Cleanse
Tone
Eyecare
Serum
Moisturize
Suncare
 

Instructions:

Lather a quarter-sized amount in hands and gently massage onto damp skin. Rinse thoroughly with warm water. Use morning and evening. For best results, follow with your favorite Perricone MD treatment and moisturizer.

Key Information

Vegan
Cruelty-free
Sensitive-safe
Non-comedogenic
Hypoallergenic
Microbiome-safe
Preservative-free
Eco-friendly
Pregnancy-safe
Oil-free

What Perricone MD Says

Product Description:

Gentle gel cleanser quickly and effectively removes excess oil, debris and impurity buildup without stripping the skin. Softens and conditions, leaving the skin looking and feeling refreshed, never dry or tight. Ideal for normal to dry skin.

About the Brand:

Founded by Dr. Nicholas Perricone, Perricone MD is a pioneer in the science of aging. This brand takes a holistic approach to skincare, combining cutting-edge ingredients with a focus on nutrition and lifestyle. Experience transformative results with products that address not just the signs of aging, but its underlying causes.

Ingredients Overview

Ingredients List

Water/Aqua/Eau, Sodium Laureth Sulfate, Cocamidopropyl Betaine, Lauryl Glucoside, PPG-2 Hydroxyethyl Coco/Isostearamide, Dimethyl MEA, Thioctic Acid, Fragrance/Parfum, Magnesium Aspartate, Zinc Gluconate, Ethylhexylglycerin, Copper Gluconate, Disodium EDTA, Sodium Chloride, Citric Acid, Phenoxyethanol

Key Ingredients

Alpha Lipoic Acid, Alpha Hydroxy Acids, Copper Complex

Ingredients Details

Cocamidopropyl Betaine

Common Name(s): Capb,cocoamidopropyl betaine,coconut betaine

CAS Number: 61789-40-0

DESCRIPTION

What It Does: Boosts foam, enhances mildness, and conditions skin and hair when combined with primary surfactants.

Why It's Used: The standard foam booster and mildness enhancer in virtually all shampoos, body washes, and facial cleansers โ€“ provides synergistic mildness improvement with anionic surfactants.

How It Works: Amphoteric (zwitterionic) character provides positive charge interaction with hair keratin for antistatic conditioning. reduces irritation of co-formulated anionic surfactants via ionic complex formation. foam stabilization via bilayer reinforcement in foam lamellae.

Typically Found In: Shampoos,body washes,facial cleansers,baby products

TECHNICAL DETAILS

Primary Category: Functional ingredient โ€“ amphoteric surfactant

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 2%โ€“15%

SOURCING & ETHICS

Vegan Status: Yes โ€“ from coconut fatty acids and dimethylaminopropylamine

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ€“2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Capb's mildness-enhancing synergy with sls has a molecular mechanism: capb's positive imidazoline head group forms an ion pair complex with sls's anionic sulfate group, reducing sls's free monomer concentration (the irritation-causing species) without significantly reducing micelle-forming capacity (the cleansing species).

Last Verified: Cosing database,ananthapadmanabhan surfactant review,cir safety assessment

Primary Sources: 2026-03-12

Dimethyl Mea

Common Name(s): Dmae,dimethylaminoethanol,membrane stabiliser anti-aging

CAS Number: N/a

DESCRIPTION

What It Does: Provides immediate skin firmness from the topical amine's interaction with skin surface proteins, reduces age-related lipofuscin accumulation in cell membranes through acetylcholine pathway enhancement, and conditions skin with mild surfactant activity.

Why It's Used: Dmae's dual immediate-effect (surface protein tightening) and long-term mechanism (membrane lipofuscin reduction) enables both instant and cumulative anti-aging claim support from one ingredient.

How It Works: Dmae as a membrane phospholipid precursor incorporates into cell membranes as dimethylethanolamine phospholipid, improving membrane fluidity and reducing cross-linked lipofuscin accumulation. at the skin surface, dmae's cationic amine group interacts with skin surface carboxylate groups creating mild surface contraction providing immediate firmness perception.

Typically Found In: Anti-aging firming,membrane health

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%โ€“3%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Dmae penetration studies show significant transdermal absorption (significantly more than most cosmetic actives) โ€” the cholinergic activity may have systemic implications at high concentrations. use at standard cosmetic concentrations (0.5โ€“3%) is considered safe.

Last Verified: Cosing database,dmae membrane stabiliser anti-aging review

Primary Sources: 2026-03-12

Lauryl Glucoside

Common Name(s): C12 glucoside,dodecyl glucoside,apg surfactant

CAS Number: 110615-47-9

DESCRIPTION

What It Does: Provides mild, naturally-derived cleansing with excellent biodegradability from glucose and lauryl alcohol.

Why It's Used: The natural cleansing standard โ€” lauryl glucoside's combination of renewability, biodegradability, mildness, and foaming makes it the benchmark natural surfactant for clean beauty facial cleansers.

How It Works: C12 alkyl chain provides cmc and foaming. glucose head group provides mild non-ionic/weakly anionic character from hydroxyl groups. very low irritation potential from polyol head group. excellent biodegradability >95% bod28 from glucoside hydrolysis. cosmos approved.

Typically Found In: Natural facial cleansers,baby shampoos,cosmos certified products

TECHNICAL DETAILS

Primary Category: Functional ingredient โ€“ alkyl glucoside surfactant

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 2%โ€“15%

SOURCING & ETHICS

Vegan Status: Yes โ€“ from corn glucose + coconut lauryl alcohol

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ€“2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Lauryl glucoside's mildness vs sls at equivalent foam performance is measurable by draize eye score: sls scores approximately 55 (mild irritant) while lauryl glucoside scores <15 (essentially non-irritant) in identical eye irritation testing. this quantitative mildness advantage explains why apg surfactants command premium pricing despite renewable/natural origin โ€” actual performance superiority justifies the cost.

Last Verified: Cosing database,cosmos standard,cir safety assessment

Primary Sources: 2026-03-12

Magnesium Aspartate

Common Name(s): Mineral salt,ionic strength modifier,skin mineralising agent

CAS Number: N/a

DESCRIPTION

What It Does: Provides mineral ion delivery to skin, modulates formulation ionic strength for viscosity and stability optimisation, and supports skin enzyme activity through essential mineral cofactor supplementation.

Why It's Used: Mineral salts are essential formulation ph and ionic strength adjusters โ€” magnesium sulfate specifically provides the mgยฒโบ ions that activate transglutaminase crosslinking during sc cornification, supporting barrier formation.

How It Works: Ionic dissociation in aqueous formulation provides free ions that modulate polymer viscosity (ionic strength reduces charge-based thickener swelling), provide mineral nutrition to skin enzymes (caยฒโบ for transglutaminase, mgยฒโบ for mgatp phosphotransferases), and adjust osmolality for skin-surface tonicity matching.

Typically Found In: All formulations,mineral skin care

TECHNICAL DETAILS

Primary Category: Active ingredient โ€“ mineral / metal active

Secondary Functions: Antimicrobial,sebum regulation,antioxidant enzyme cofactor

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.01%โ€“5%

SOURCING & ETHICS

Vegan Status: Yes โ€“ mineral

Halal Status: Yes

Source Notes: Mineral/inorganic compound. cosmetic or pharmaceutical grade.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating at recommended concentrations.

Safe for Sensitive Skin: Yes at recommended concentrations

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile at cosmetic concentrations. ewg score: 1โ€“2.

Works Well With: Niacinamide,salicylic acid,other actives

Avoid Combining With: No significant incompatibilities at standard concentrations

SCIENTIFIC NOTE

Mgยฒโบ and caยฒโบ are essential cofactors for the sc cornification process โ€” caยฒโบ specifically drives the caยฒโบ gradient across the epidermis (high in outer sc, low in basal layer) that regulates keratinocyte differentiation through caยฒโบ-calmodulin signalling.

Last Verified: Cosing database,magnesium aspartate mineral salt formulation review

Primary Sources: 2026-03-12