Glad2Glow Tremella Vita B5 Sensitive Calming Moisturizer 30G

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

1-2-hexanediol has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,1-2-hexanediol technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Reduces skin inflammation, soothes irritation, promotes wound healing, and enhances penetration of co-formulated actives.

Why It's Used: Premium natural soothing active with combined anti-inflammatory, wound healing, and penetration-enhancing activity – clinically validated across sensitive, reactive, and irritated skin types.

How It Works: Inhibits nf-kb pathway reducing pro-inflammatory cytokines il-1β, il-6, tnf-α. enhances stratum corneum lipid fluidity increasing penetration of co-delivered actives. antimicrobial against s. aureus and c. albicans. promotes keratinocyte migration for wound healing.

Typically Found In: Sensitive skin products,post-procedure formulations,anti-irritant formulas,wound healing

TECHNICAL DETAILS

Primary Category: Active ingredient – soothing / anti-inflammatory

Secondary Functions: Anti-inflammatory,penetration enhancement,antimicrobial

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–1%

SOURCING & ETHICS

Vegan Status: Yes – from candeia tree (vanillosmopsis erythropappa) or synthetic

Halal Status: Yes

Source Notes: Natural (-)-alpha-bisabolol from brazilian candeia tree is more sustainable and potent than chamomile-derived bisabolol. synthetic (±)-bisabolol is racemic with slightly lower anti-inflammatory potency.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; ideal for reactive and sensitive skin.

Safe for Sensitive Skin: Yes – particularly recommended for sensitive skin

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,panthenol,allantoin,hyaluronic acid,centella asiatica

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Bisabolol's dual function as both an anti-inflammatory and a penetration enhancer is synergistic – by reducing the inflammatory response that increases barrier tightness while simultaneously fluidizing stratum corneum lipids, it provides enhanced delivery of co-formulated actives in the very conditions where delivery is most needed.

Last Verified: Cosing database,piazza et al. bisabolol anti-inflammatory study,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Smooths and softens skin by filling intercorneocyte spaces, reducing friction, and providing a pleasant aesthetic skin feel in formulations.

Why It's Used: Synthetic esters provide tailored aesthetic properties — spreadability, skin feel, volatility, refractive index — that natural oils alone cannot consistently deliver.

How It Works: The ester molecule fills microscopic surface irregularities between corneocytes, reducing coefficient of friction, reflecting light uniformly, and providing a lubrication layer that protects the skin surface.

Typically Found In: Moisturizers,sunscreens,color cosmetics,body lotions,lip products

TECHNICAL DETAILS

Primary Category: Synthetic emollients

Secondary Functions: Emollient

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1–20%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced ester emollient; no animal components.

SKIN COMPATIBILITY

Irritancy Rating: 1

Comedogenicity Rating: 1

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Silicones,uv filters,other emollients

Avoid Combining With: Strongly alkaline conditions (risk of saponification of ester-type emollients)

SCIENTIFIC NOTE

The spreading coefficient of an emollient is governed by its surface tension, viscosity, and polarity. esters with branched alkyl chains (e.g., isopropyl, isostearyl) spread rapidly and leave a non-tacky film; linear long-chain esters provide more substantive moisturization. hlb value determines the preferred formulation system (w/o vs o/w emulsions).

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; ingredient-specific safety and efficacy literature

Primary Sources: 2025-01-15

DESCRIPTION

What It Does: Provides silicone-characteristic silky feel and skin protection with adjustable viscosity.

Why It's Used: The benchmark cosmetic silicone – sets the gold standard for silky application feel, spreadability, and skin protection in virtually all skin care categories.

How It Works: Polydimethylsiloxane chain flexibility provides extremely low surface tension and high spreadability. inert si-o backbone provides chemical stability and excellent skin tolerance. occlusive film formation reduces tewl. higher viscosity grades provide more intense conditioning.

Typically Found In: Moisturizers,foundations,primers,sunscreens – nearly universal

TECHNICAL DETAILS

Primary Category: Functional ingredient – polydimethylsiloxane

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–30%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Dimethicone's exceptional silky feel arises from its very low intermolecular attractive forces (weak van der waals forces due to non-polar methyl groups) that allow silicone chains to slide freely over skin. the coefficient of kinetic friction for pdms against skin (~0.04) is among the lowest of any cosmetic material – explaining why even small amounts transform product feel.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Hydrates by forming a water-shell around skin biomolecules, stabilises cellular membranes against heat/uv stress, and reduces inflammatory cytokine release in stressed skin.

Why It's Used: Provides dual humectancy plus cellular protection — unique among humectants for its documented ability to stabilise skin proteins and membranes against uv and environmental stress, not just attract water.

How It Works: Ectoin's tetrahydropyrimidine ring forms an ordered hydration shell around proteins, lipid bilayers, and dna through kosmotropic water structuring. this preferential hydration excludes denaturants and uv-stress mediators from biomolecule surfaces while simultaneously providing humectant moisture binding.

Typically Found In: Sensitive skin,uv protection actives,anti-inflammatory

TECHNICAL DETAILS

Primary Category: Functional ingredient – humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Extremophile bacteria accumulate ectoin at up to 15% intracellular concentration to survive 100°c temperatures and extreme salinity — the same biomolecule protection mechanism applies to human skin cells at cosmetic concentrations.

Last Verified: Cosing database,ectoin extremophile anti-stress clinical review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antimicrobial skin conditioning with deodorant activity and preservation system enhancement.

Why It's Used: Multifunctional clean beauty preservation active — ethylhexylglycerin provides antimicrobial, deodorant, and skin conditioning in a single ingredient accepted in most natural cosmetic certification schemes.

How It Works: Glycerol ether provides antimicrobial via bacterial membrane phospholipid disruption. deodorant activity via reduction of underarm lipase enzyme activity (similar mechanism to triethyl citrate). skin conditioning from glycerol humectant component. synergistic with phenoxyethanol and diols.

Typically Found In: Natural preservation systems,deodorants,skin conditioning products

TECHNICAL DETAILS

Primary Category: Functional ingredient – antimicrobial glycerol ether

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–0.5%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Ethylhexylglycerin's deodorant mechanism is pharmacologically identical to triethyl citrate: both inhibit skin surface microbial lipase enzymes that convert odourless triglycerides to odorous free fatty acids. the glycerol ether structure of ethylhexylglycerin, combined with the 2-ethylhexyl chain, provides lipase inhibition similar to ester-based lipase inhibitors from a different chemical class.

Last Verified: Cosing database,schülke sensiva sc 10 technical data,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides antioxidant and preservative-boosting activity in a naturally-occurring clean-label phenolic.

Why It's Used: Clean-label preservation support — hydroxyacetophenone provides antioxidant and antimicrobial-boosting properties from a naturally-occurring compound accepted in natural cosmetic certifications.

How It Works: Para-hydroxyl group provides antioxidant radical scavenging. disrupts bacterial cell membrane penetration for preservative system boosting. anti-inflammatory via nf-kb inhibition. occurs naturally in plants including pear and raspberry as a secondary metabolite.

Typically Found In: Natural preservation systems,antioxidant serums,clean beauty

TECHNICAL DETAILS

Primary Category: Functional ingredient – antioxidant preservative booster

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–1%

SOURCING & ETHICS

Vegan Status: Yes – natural from plants or synthetic

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Hydroxyacetophenone's natural occurrence in fruits (pear, raspberry, passion fruit) at detectable concentrations provides clean-label justification for use in natural cosmetics. its cosmos certification acceptance reflects the growing demand for functional preservation ingredients that meet natural certification criteria — an ingredient with genuine plant-origin credentials that provides meaningful antimicrobial and antioxidant functions simultaneously.

Last Verified: Cosing database,cosmos-standard approved ingredients,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides natural phospholipid emulsification with barrier-compatible delivery and liposome-forming properties.

Why It's Used: The most biologically authentic emulsifier – identical to cell membrane composition providing barrier-compatible delivery and liposome formation unavailable from synthetic emulsifiers.

How It Works: Phosphatidylcholine (pc), phosphatidylethanolamine (pe), phosphatidylinositol (pi) mixture provides hlb 7-12 for o/w emulsification. forms liposomal bilayers for active encapsulation. pc/pe/pi composition mirrors cell membrane for barrier-compatible delivery.

Typically Found In: Natural cosmetics,liposomal products,barrier repair,penetration-enhanced formulas

TECHNICAL DETAILS

Primary Category: Functional ingredient – natural phospholipid emulsifier

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–10%

SOURCING & ETHICS

Vegan Status: Conditional – soy lecithin (vegan); egg lecithin (not vegan)

Halal Status: Conditional – soy (halal); egg (verify)

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Lecithin's phospholipid composition mirrors the composition of the stratum corneum's own lamellar bodies that deliver barrier lipids to the skin surface. this structural mimicry allows lecithin-based delivery systems to integrate seamlessly with the barrier lipid structure, exploiting the same transport pathway the skin uses for its own lipid secretion.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides humectant and solvent functionality with improved skin feel vs butylene glycol.

Why It's Used: Premium humectant solvent with superior skin feel to conventional diols for elegant premium formulation textures.

How It Works: Branched c4 structure provides good humectant activity. branching reduces viscosity and stickiness vs linear propylene glycol. excellent solvent for challenging actives. antimicrobial boosting from diol structure.

Typically Found In: Premium serums,active delivery systems

TECHNICAL DETAILS

Primary Category: Functional ingredient – humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–10%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Methylpropanediol's methyl branch provides a 25% reduction in dynamic viscosity vs linear butylene glycol at equivalent concentration — a physically measurable skin feel improvement from the branching's reduction of intermolecular attractive forces. this viscosity reduction translates directly to the 'less sticky, lighter' skin feel that premium formulations require.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12