Gentle Cleanser

DESCRIPTION

What It Does: Provides antioxidant protection from polyphenol radical scavenging, anti-inflammatory activity from terpenoid nf-kb/cox pathway inhibition, and skin conditioning from the phytochemical secondary metabolite complex.

Why It's Used: Artemisia vulgaris extract is selected for the characteristic secondary metabolite signature of artemisia vulgaris — whether polyphenols, terpenoids, alkaloids, or polysaccharides, the phytochemical profile provides antioxidant, anti-inflammatory, or skin conditioning benefits specific to this botanical species.

How It Works: Polyphenol catechol h-atom donation scavenges ros (rate constants 10⁶-10⁹ m⁻¹s⁻¹); terpenoids inhibit iκb kinase blocking nf-κb; flavonoids compete at cox-1/2; alkaloids modulate specific receptor targets for additional bioactivity.

Typically Found In: Botanical skin care

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Conditional

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Standardise to marker compound for consistent bioactivity — field-grown material varies 3-10× in secondary metabolite content.

Last Verified: Cosing database,artemisia vulgaris extract botanical extract review

Primary Sources: 2026-03-22

DESCRIPTION

What It Does: Provides antioxidant protection from reactive oxygen species, reduces inflammatory cytokine production in skin, and conditions skin surface through the plant's secondary metabolite complex.

Why It's Used: Chosen for its natural origin narrative, traditional use heritage, and multi-functional phytochemical profile that supports several concurrent skin care claims from one ingredient.

How It Works: Polyphenols, terpenoids, and alkaloids in the extract scavenge ros via hydrogen atom transfer, inhibit nf-kb or cox-2 inflammatory pathways, and interact with skin surface proteins for conditioning.

Typically Found In: Botanical skin care,natural products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Plant secondary metabolites evolved as uv photoprotectants and antimicrobial agents — mechanisms that directly translate to cosmetic antioxidant and anti-inflammatory activity in human skin.

Last Verified: Cosing database,camellia sinensis leaf extract botanical review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Reduces surface tension at oil-water interfaces, enabling effective cleansing, emulsification, and formulation stability.

Why It's Used: Surface-active agents are essential for emulsification, cleansing, and stabilization of cosmetic formulations containing both aqueous and lipid phases.

How It Works: The amphiphilic molecular structure positions the hydrophilic head in water and the lipophilic tail in oils, creating micelles that solubilize sebum, dirt, and oil-soluble impurities for rinsing in cleansers or stable emulsions in leave-on products.

Typically Found In: Cleansers,shampoos,body washes,foaming treatments

TECHNICAL DETAILS

Primary Category: Surfactants

Secondary Functions: Emulsifying,cleansing

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5–30%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetic or semi-synthetic surfactant; no animal components.

SKIN COMPATIBILITY

Irritancy Rating: 1900-01-01 00:00:00 -0800

Sensitivity Concerns: May cause irritation or stinging in sensitive or barrier-compromised skin at high concentrations; patch test recommended.

Safe for Sensitive Skin: Conditional

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. mildly irritating to some individuals at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Other surfactants,thickeners,conditioning agents

Avoid Combining With: High concentrations in sensitive skin formulations

SCIENTIFIC NOTE

Surfactant critical micelle concentration (cmc) determines the threshold for emulsification: above the cmc, amphiphilic molecules self-assemble into micelles with hydrophobic cores that solubilize oils. hlb (hydrophile-lipophile balance) value predicts surfactant function: hlb 3–6 for w/o emulsifiers, 8–18 for o/w emulsifiers, >15 for solubilizers.

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; ingredient-specific safety and efficacy literature

Primary Sources: 2025-01-15

DESCRIPTION

What It Does: Provides antioxidant protection, soothing anti-inflammatory effects, and skin-conditioning benefits through plant-derived polyphenols and phytochemicals.

Why It's Used: Plant extracts concentrate bioactive phytochemicals evolved for environmental protection — uv, microbial, and oxidative stressors — that translate to skin benefits.

How It Works: Polyphenols (flavonoids, phenolic acids) inhibit nf-κb-mediated inflammatory signaling, scavenge reactive oxygen species through electron donation, and chelate pro-oxidant metal ions to reduce oxidative skin damage.

Typically Found In: Serums,toners,moisturizers,masks,essences

TECHNICAL DETAILS

Primary Category: Botanical extracts

Secondary Functions: Antioxidant,anti-inflammatory

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1–10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract; no animal components.

SKIN COMPATIBILITY

Irritancy Rating: 1

Comedogenicity Rating: 0

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Niacinamide,hyaluronic acid,vitamin c,ceramides

Avoid Combining With: Strong oxidizing agents

SCIENTIFIC NOTE

Plant secondary metabolites (flavonoids, terpenes, phenolic acids) are biosynthesized as defense compounds against uv, herbivores, and pathogens. their anti-inflammatory activity typically derives from competitive inhibition of cox-2 and 5-lox enzymes (ic50 1–50 µm), while antioxidant activity involves single electron transfer (set) and hydrogen atom transfer (hat) mechanisms with structure-dependent rate constants.

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; phytochemical and ethnobotanical literature

Primary Sources: 2025-01-15

DESCRIPTION

What It Does: Provides antioxidant protection, soothing anti-inflammatory effects, and skin-conditioning benefits through plant-derived polyphenols and phytochemicals.

Why It's Used: Plant extracts concentrate bioactive phytochemicals evolved for environmental protection — uv, microbial, and oxidative stressors — that translate to skin benefits.

How It Works: Polyphenols (flavonoids, phenolic acids) inhibit nf-κb-mediated inflammatory signaling, scavenge reactive oxygen species through electron donation, and chelate pro-oxidant metal ions to reduce oxidative skin damage.

Typically Found In: Serums,toners,moisturizers,masks,essences

TECHNICAL DETAILS

Primary Category: Botanical extracts

Secondary Functions: Antioxidant,anti-inflammatory

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1–10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract; no animal components.

SKIN COMPATIBILITY

Irritancy Rating: 1

Comedogenicity Rating: 0

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Niacinamide,hyaluronic acid,vitamin c,ceramides

Avoid Combining With: Strong oxidizing agents

SCIENTIFIC NOTE

Plant secondary metabolites (flavonoids, terpenes, phenolic acids) are biosynthesized as defense compounds against uv, herbivores, and pathogens. their anti-inflammatory activity typically derives from competitive inhibition of cox-2 and 5-lox enzymes (ic50 1–50 µm), while antioxidant activity involves single electron transfer (set) and hydrogen atom transfer (hat) mechanisms with structure-dependent rate constants.

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; phytochemical and ethnobotanical literature

Primary Sources: 2025-01-15

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Sodium chloride has an established safety profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,sodium chloride technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides excellent foam and cleansing with significantly lower irritation than sls.

Why It's Used: The dominant primary surfactant in mainstream personal care – improved mildness over sls while retaining excellent foam and cleansing performance.

How It Works: Ethoxylation (2-3 eo units) inserts polyethylene oxide spacer between dodecyl chain and sulfate, sterically shielding sulfate from direct protein contact, reducing irritation vs sls. full micellar cleansing capacity retained.

Typically Found In: Shampoos,body washes,facial cleansers,household cleansers

TECHNICAL DETAILS

Primary Category: Functional ingredient – ethoxylated anionic surfactant

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 2%–15%

SOURCING & ETHICS

Vegan Status: Yes – from coconut fatty acids

Halal Status: Yes

Source Notes: Ethoxylation process can generate trace 1,4-dioxane impurity – reputable manufacturers purify to <1ppm. look for sles certified with dioxane specification.

SKIN COMPATIBILITY

Irritancy Rating: 2/5 – low to moderate (significantly milder than sls)

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-established safety. ewg score: 3 (1,4-dioxane impurity concern – use sles from ethoxylation with purification confirmation).

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Sles's reduced irritation vs sls directly correlates with the degree of ethoxylation – sles-2 (2 eo units) is milder than sls but not as mild as sles-3 (3 eo units). each ethylene oxide unit adds steric shielding around the sulfate group, progressively reducing its protein-binding and denaturation capacity.

Last Verified: Cosing database,ananthapadmanabhan et al. surfactant review,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Sodium lauroyl oat amino acids has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,sodium lauroyl oat amino acids technical literature

Primary Sources: 2026-03-12