EverActive C&E®+ Peptide

DESCRIPTION

What It Does: Provides antioxidant protection from reactive oxygen species, reduces inflammatory cytokine production in skin, and conditions skin surface through the plant's secondary metabolite complex.

Why It's Used: Chosen for its natural origin narrative, traditional use heritage, and multi-functional phytochemical profile that supports several concurrent skin care claims from one ingredient.

How It Works: Polyphenols, terpenoids, and alkaloids in the extract scavenge ros via hydrogen atom transfer, inhibit nf-kb or cox-2 inflammatory pathways, and interact with skin surface proteins for conditioning.

Typically Found In: Botanical skin care,natural products

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Plant secondary metabolites evolved as uv photoprotectants and antimicrobial agents — mechanisms that directly translate to cosmetic antioxidant and anti-inflammatory activity in human skin.

Last Verified: Cosing database,camellia sinensis leaf extract botanical review

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.

Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.

How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.

Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners

TECHNICAL DETAILS

Primary Category: Humectant

Secondary Functions: Skin barrier support,emollient,solvent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–30% (typical: 3–10%)

SOURCING & ETHICS

Vegan Status: Yes – plant-derived (coconut, soy, palm) or synthetic

Halal Status: Yes – when plant-derived or synthetic; verify source with supplier

Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; non-irritating at all standard concentrations

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).

Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas

Avoid Combining With: No known incompatibilities at standard concentrations

SCIENTIFIC NOTE

Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides simultaneous stimulation of 6 major skin matrix proteins for comprehensive anti-aging matrix restoration.

Why It's Used: The most comprehensive matrix-stimulating peptide — matrixyl synthe'6's simultaneous upregulation of all six major skin matrix proteins provides more complete extracellular matrix restoration than any single-target peptide.

How It Works: Activates multiple fibroblast receptor pathways simultaneously. upregulates collagen i, iii, iv synthesis. stimulates fibronectin, laminin-5, and ha synthase (has2) expression. comprehensive matrix restoration reduces wrinkle depth from all collagen and ha-dependent skin architecture components.

Typically Found In: Premium anti-aging serums,comprehensive anti-aging products

TECHNICAL DETAILS

Primary Category: Active ingredient – signal peptide

Secondary Functions: Collagen stimulation,skin firming,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.0001%–0.01%

SOURCING & ETHICS

Vegan Status: Yes – synthetic

Halal Status: Yes

Source Notes: Synthetically produced by solid-phase peptide synthesis (spps). may be palmitoylated for stability.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Exceptional safety profile. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,retinol,vitamin c,niacinamide

Avoid Combining With: Avoid mixing with high-concentration ahas at same ph (may hydrolyze peptide bonds)

SCIENTIFIC NOTE

Matrixyl synthe'6's six-protein stimulation was characterised by sederma's research demonstrating simultaneous mrna upregulation for all six matrix proteins in human skin explants. the breadth of matrix stimulation from a single tripeptide reflects the convergent gene regulation of extracellular matrix proteins — many share common transcription factor binding sites (ap-1, sp1) allowing coordinated upregulation from a single signalling peptide.

Last Verified: Cosing database,sederma matrixyl synthe'6 technical data

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Helps oil and water blend in creams and lotions while conditioning skin.

Why It's Used: Polyglyceryl-3 head provides hydrophilicity (hlb ~5–7); coconut fatty acids tail provides oil-phase affinity; natural-origin compatible.

How It Works: Polyglycerol-3 backbone with coconut fatty acids ester tail; hlb ~5–7; polyglyceryl esters are widely used natural-origin emulsifiers suitable for organic cosmetic certification.

Typically Found In: O/w emulsions,natural cosmetics,organic formulations,skin conditioning products

TECHNICAL DETAILS

Primary Category: Functional ingredient – emulsifier

Secondary Functions: Skin conditioning,surfactant,natural origin

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Polyglycerin from vegetable glycerol polymerization; coconut fatty acids acid from plant sources; naturally derived.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low

Sensitivity Concerns: Very mild; suitable for sensitive skin. natural-origin ingredient.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Natural oils,plant butters,other natural emulsifiers,humectants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Pg-3 cocoate; mixed coconut fatty acids; balanced to w/o emulsification hlb ~5-7; widely used natural emulsifier.

Last Verified: Cosing database,inci dictionary,supplier technical data

Primary Sources: 2026-03-27

DESCRIPTION

What It Does: Helps oil and water blend in creams and lotions while conditioning skin.

Why It's Used: Polyglyceryl-4 head provides hydrophilicity (hlb ~7–9); capric acid (c10) tail provides oil-phase affinity; natural-origin compatible.

How It Works: Polyglycerol-4 backbone with capric acid (c10) ester tail; hlb ~7–9; polyglyceryl esters are widely used natural-origin emulsifiers suitable for organic cosmetic certification.

Typically Found In: O/w emulsions,natural cosmetics,organic formulations,skin conditioning products

TECHNICAL DETAILS

Primary Category: Functional ingredient – emulsifier

Secondary Functions: Skin conditioning,surfactant,natural origin

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Polyglycerin from vegetable glycerol polymerization; capric acid (c10) acid from plant sources; naturally derived.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low

Sensitivity Concerns: Very mild; suitable for sensitive skin. natural-origin ingredient.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Natural oils,plant butters,other natural emulsifiers,humectants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Pg-4 caprate; c10 capric chain; balanced emulsification hlb ~7-9; non-greasy.

Last Verified: Cosing database,inci dictionary,supplier technical data

Primary Sources: 2026-03-27

DESCRIPTION

What It Does: Helps oil and water blend in creams and lotions while conditioning skin.

Why It's Used: Polyglyceryl-6 head provides hydrophilicity (hlb ~9–11); caprylic acid (c8) tail provides oil-phase affinity; natural-origin compatible.

How It Works: Polyglycerol-6 backbone with caprylic acid (c8) ester tail; hlb ~9–11; polyglyceryl esters are widely used natural-origin emulsifiers suitable for organic cosmetic certification.

Typically Found In: O/w emulsions,natural cosmetics,organic formulations,skin conditioning products

TECHNICAL DETAILS

Primary Category: Functional ingredient – emulsifier

Secondary Functions: Skin conditioning,surfactant,natural origin

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Polyglycerin from vegetable glycerol polymerization; caprylic acid (c8) acid from plant sources; naturally derived.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low

Sensitivity Concerns: Very mild; suitable for sensitive skin. natural-origin ingredient.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Natural oils,plant butters,other natural emulsifiers,humectants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Pg-6 caprylate; very short chain c8; very high hydrophilicity from pg-6; o/w emulsification hlb ~9-11; mild antimicrobial.

Last Verified: Cosing database,inci dictionary,supplier technical data

Primary Sources: 2026-03-27

DESCRIPTION

What It Does: Helps oil and water blend in creams and lotions while conditioning skin.

Why It's Used: Polyglyceryl-6 head provides hydrophilicity (hlb ~9–11); ricinoleic acid (castor oil) tail provides oil-phase affinity; natural-origin compatible.

How It Works: Polyglycerol-6 backbone with ricinoleic acid (castor oil) ester tail; hlb ~9–11; polyglyceryl esters are widely used natural-origin emulsifiers suitable for organic cosmetic certification.

Typically Found In: O/w emulsions,natural cosmetics,organic formulations,skin conditioning products

TECHNICAL DETAILS

Primary Category: Functional ingredient – emulsifier

Secondary Functions: Skin conditioning,surfactant,natural origin

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.5%–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Polyglycerin from vegetable glycerol polymerization; ricinoleic acid (castor oil) acid from plant sources; naturally derived.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low

Sensitivity Concerns: Very mild; suitable for sensitive skin. natural-origin ingredient.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Natural oils,plant butters,other natural emulsifiers,humectants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Pg-6 ricinoleate; castor-derived; ricinoleic oh group adds polarity; o/w emulsification hlb ~9-11.

Last Verified: Cosing database,inci dictionary,supplier technical data

Primary Sources: 2026-03-27

DESCRIPTION

What It Does: Provides humectant and solvent functionality from sustainable corn-based fermentation.

Why It's Used: Bio-based propylene glycol alternative from renewable corn — propanediol provides equivalent functionality to propylene glycol with sustainable renewable feedstock and superior skin feel.

How It Works: Two oh groups provide humectant water binding. excellent solvent for fragrances, actives, and preservatives. mild antimicrobial from diol structure for preservative system boosting. renew corn fermentation origin (dupont zemea process). better skin feel than propylene glycol — less sticky.

Typically Found In: Virtually all cosmetic categories as pg alternative

TECHNICAL DETAILS

Primary Category: Functional ingredient – humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–20%

SOURCING & ETHICS

Vegan Status: Yes – from corn sugar fermentation

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Propanediol's dupont tate & lyle bio products 'zemea' process ferments corn sugar to 1,3-propanediol using engineered e. coli — one of the first commercially viable bio-fermentation routes to a cosmetic diol previously made only from petroleum. the renewable route produces chemically identical 1,3-propanediol while reducing carbon footprint by approximately 40% vs petrochemical synthesis.

Last Verified: Cosing database,dupont tate & lyle zemea technical data,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides stable vitamin e delivery with antioxidant activity after esterase hydrolysis in skin.

Why It's Used: The formulation-stable vitamin e — tocopheryl acetate's ester protection prevents oxidative degradation during shelf life while releasing active tocopherol in skin for equivalent biological activity.

How It Works: Acetate ester blocks the phenolic oh group responsible for oxidation and radical scavenging. skin esterases cleave acetate bond releasing free tocopherol. released tocopherol provides lipid peroxyl radical scavenging in cell membranes. also provides direct emollient and skin conditioning.

Typically Found In: Moisturisers,sunscreens,anti-aging products — extremely widespread

TECHNICAL DETAILS

Primary Category: Active ingredient – stable vitamin e ester

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Conditional – natural from vegetable oils (soy, sunflower); synthetic dl-form

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: The d-alpha-tocopheryl acetate (natural isomer) is biologically superior to dl-alpha-tocopheryl acetate (racemic synthetic) for skin antioxidant activity. ingredient label d- vs dl- prefix identifies natural vs synthetic origin.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Tocopheryl acetate's conversion to active tocopherol in skin is quantitatively efficient: skin esterase activity is sufficient to cleave 60-80% of applied tocopheryl acetate within 24 hours of application. however, the conversion rate varies with skin condition (eczematous or barrier-compromised skin has reduced esterase activity), meaning tocopheryl acetate efficacy may be reduced precisely in the skin conditions that most need antioxidant support.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12