Origins
DR. ANDREW WEIL FOR ORIGINS™ MEGA-MUSHROOM RELIEF & RESILIENCE ADVANCED FACE SERUM
DR. ANDREW WEIL FOR ORIGINS™ MEGA-MUSHROOM RELIEF & RESILIENCE ADVANCED FACE SERUM
Origins
dr-andrew-weil-for-origins-mega-mushroom-relief-resilience-advanced-face-serum
Serum
9818390561061
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How often will you use this product?
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Highlights
WHAT IS IT?
Advanced Face Serum with multiple adaptogens
FEATURES
Improves texture, reduces visible redness, boosts skin barrier, provides healthy-looking radiance
BEST FOR
All skin types
CHECKS
Free of parabens, phthalates, formaldehyde, SLS, mineral oil, petrolatum, paraffin, DEA, polyethylene beads, animal ingredients
Who Is It For?
Adults With Sensitive SkinWhat Does It Help With?
Redness Reduction Texture Improvement Skin Barrier Strengthening Irritation ReliefBudget
Premium ($76-$150)How To Use
Which routine should it be used in?
Instructions:
Key Information
What Origins Says
Product Description:
Our best serum for sensitive skin—hello, super soothing—improves texture, reduces visible redness and now has more irritation-fighting Adaptogens than ever, including Licorice Root, Astragalus Root, and Reishi Mushroom. The advanced formula boosts skin's barrier and delivers Mega, healthy-looking radiance.
About the Brand:
Ingredients Overview
Ingredients List
water\aqua\eau • simmondsia chinensis (jojoba) seed oil • olea europaea (olive) fruit oil • saccharomyces ferment filtrate • caprylic/capric/myristic/stearic triglyceride • glycerin • hydrogenated lecithin • butyrospermum parkii (shea) butter • camelina sativa seed oil • hypnea musciformis (algae) extract • dimer dilinoleyl dimer dilinoleate • ganoderma lucidum (mushroom) extract • fuscoporia obliqua sclerotium extract • phellinus linteus extract • astragalus membranaceus (milk vetch) root extract • dipotassium glycyrrhizate • lactobacillus ferment • sodium hyaluronate • salicylic acid • glucosamine hcl • zingiber officinale (ginger) root extract • caffeine • laminaria saccharina extract • hippophae rhamnoides extract • castanea sativa (chestnut) seed extract • gelidiella acerosa extract • oryzanol • tocopherol • tocotrienols • phytosterols • magnesium aluminum silicate • butylene glycol • coco-caprylate/caprate • squalene • xanthan gum • biosaccharide gum-1 • elaeis guineensis (palm) oil • vegetable oil\olus oil\huile végétale • polyglyceryl-3 diisostearate • ethylhexylglycerin • caprylyl glycol • polysorbate 20 • sodium phytate • phenoxyethanol • chlorphenesin • sorbic acid • potassium sorbate • citrus aurantium dulcis (orange) oil* • lavandula angustifolia (lavender) oil* • pogostemon cablin (patchouli) oil* • citrus nobilis (mandarin orange) peel oil* • pelargonium graveolens (geranium) flower oil* • boswellia carterii oil* • limonene • linalool • geraniol • citronellol • * essential oil
Key Ingredients
Astragalus Root, Licorice Root, Reishi Mushroom, Fermented Chaga Mushroom, Lactobacillus Ferment, Red Algae
Ingredients Details
Caprylic/capric/myristic/stearic Triglyceride
Common Name(s): Caprylic/capric/myristic/stearic triglyceride
DESCRIPTION
What It Does: Delivers targeted skin-conditioning or bioactive benefits through a specific mechanism of action suited to the formulation's intended purpose.
Why It's Used: Specialty actives address specific skin concerns through targeted molecular mechanisms, providing efficacy beyond what base formulation ingredients alone can achieve.
How It Works: The bioactive compound interacts with specific molecular targets in skin cells or the extracellular matrix — enzymes, receptors, structural proteins, or signaling molecules — triggering beneficial biological responses.
Typically Found In: Serums,treatments,moisturizers,specialty products
TECHNICAL DETAILS
Primary Category: Specialty actives
Secondary Functions: Skin-conditioning,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01–5%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Specialty active ingredient; check individual sourcing for vegan status.
SKIN COMPATIBILITY
Irritancy Rating: 1
Comedogenicity Rating: 0
Sensitivity Concerns: Low sensitization potential at recommended use concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.
Works Well With: Niacinamide,hyaluronic acid,vitamin c,peptides
Avoid Combining With: Incompatible with oxidizing agents; check ph stability
SCIENTIFIC NOTE
Specialty actives typically work through enzyme inhibition (e.g., tyrosinase inhibition for brightening, mmp inhibition for anti-aging), receptor activation (e.g., retinoid receptors, ppar-γ for barrier genes), or transcription factor modulation (e.g., nrf2 for antioxidant gene upregulation). structure-activity relationships determine potency and selectivity.
Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; ingredient-specific safety and efficacy literature
Primary Sources: 2025-01-15
Glycerin
Common Name(s): Glycerol,glycerine,1,2,3-propanetriol
CAS Number: 56-81-5
DESCRIPTION
What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.
Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.
How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.
Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners
TECHNICAL DETAILS
Primary Category: Humectant
Secondary Functions: Skin barrier support,emollient,solvent
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1%–30% (typical: 3–10%)
SOURCING & ETHICS
Vegan Status: Yes – plant-derived (coconut, soy, palm) or synthetic
Halal Status: Yes – when plant-derived or synthetic; verify source with supplier
Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low; non-irritating at all standard concentrations
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).
Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas
Avoid Combining With: No known incompatibilities at standard concentrations
SCIENTIFIC NOTE
Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.
Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder
Primary Sources: 2026-03-12
Olea Europaea (olive) Fruit Oil
Common Name(s): Olea europaea (olive) fruit oil,botanical oil/butter,phytochemical active
CAS Number: N/a
DESCRIPTION
What It Does: Provides emollient conditioning, essential fatty acid supplementation, and barrier lipid support.
Why It's Used: Natural carrier oils integrate into sc lipid bilayers for genuine barrier emolliency.
How It Works: Fatty acid triglycerides deliver oleic, linoleic, and linolenic acids for sc integration and essential fatty acid barrier repair.
Typically Found In: Botanical skin care,natural products
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–30%
SOURCING & ETHICS
Vegan Status: Conditional
Halal Status: Conditional
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Plant secondary metabolites evolved for uv photoprotection and pathogen defence — mechanisms directly translatable to cosmetic antioxidant and anti-inflammatory activity in human skin.
Last Verified: Cosing database,olea europaea (olive) fruit oil botanical review
Primary Sources: 2026-03-12
Saccharomyces Ferment Filtrate
Common Name(s): Saccharomyces ferment filtrate,cosmetic active,functional ingredient
CAS Number: N/a
DESCRIPTION
What It Does: Delivers characteristic cosmetic function at recommended use concentration.
Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.
How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.
Typically Found In: Skin care formulations
TECHNICAL DETAILS
Primary Category: Active ingredient – cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–10%
SOURCING & ETHICS
Vegan Status: Conditional
Halal Status: Yes
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Saccharomyces ferment filtrate has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.
Last Verified: Cosing database,saccharomyces ferment filtrate technical literature
Primary Sources: 2026-03-12