DEFENSE Nightly Reconditioning Moisturizer

Paula's Choice

DEFENSE Nightly Reconditioning Moisturizer

DEFENSE Nightly Reconditioning Moisturizer

Paula's Choice

defense-nightly-reconditioning-moisturizer

Moisturize

9818304872741

Morning or Evening?

Morning
Evening
Both

How often will you use this product?

Everyday
Every other day
Every 3 days
Every 4 days
Every 5 days
Every 6 days
Once a week
Twice a week
On specific days
As needed
On rotation

Notes

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Compatibility Score

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Ingredients
Biological
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How It Fits Into Your Skincare Routine

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Highlights

WHAT IS IT?

Night Moisturizer

FEATURES

Antioxidant-rich formula that helps defend against environmental stress

BEST FOR

Oily, Combination, Sensitive, Dry, Normal

CHECKS

Free of alcohol, fragrances, parabens, sulfates, silicon

Who Is It For?

Adults All Genders

What Does It Help With?

Hydration Environmental Protection Skin Barrier Repair

Budget

Mid-range ($30-$75)

How To Use

Which routine should it be used in?

Morning
Evening
 
Cleanse
Tone
Eyecare
Serum
Moisturize
Suncare
 

Instructions:

Apply as the last step in your evening skincare routine

Key Information

Vegan
Cruelty-free
Sensitive-safe
Non-comedogenic
Hypoallergenic
Microbiome-safe
Preservative-free
Eco-friendly
Pregnancy-safe
Oil-free

What Paula's Choice Says

Product Description:

An antioxidant-enriched moisturizer that helps skin defend against environmental stress while restoring hydration overnight.

About the Brand:

Paula's Choice revolutionizes skincare with its research-driven approach and transparent ingredient lists. Founded by Paula Begoun, this brand offers effective, no-nonsense formulations backed by scientific evidence. Experience the power of evidence-based skincare with Paula's Choice's targeted treatments that deliver real, measurable results.

Ingredients Overview

Ingredients List

Water, Butylene-Glycol, Glycerin, Dimethicone

Key Ingredients

Antioxidants, Peptides

Ingredients Details

Butylene Glycol

Common Name(s): 1,3-butanediol,bg,1,3-butylene glycol

CAS Number: 107-88-0

DESCRIPTION

What It Does: Provides humectant hydration and active ingredient solubilization with excellent skin feel.

Why It's Used: Preferred glycol humectant in premium and k-beauty formulations for superior skin feel vs propylene glycol with equivalent functionality.

How It Works: Two hydroxyl groups at 1,3-positions provide water binding and solvent activity. better tolerated than propylene glycol with minimal sensitization risk. 4-carbon backbone provides slightly greater hydrophobic character enabling dissolution of less polar actives vs pg.

Typically Found In: Toners,essences,serums,k-beauty formulas

TECHNICAL DETAILS

Primary Category: Functional ingredient โ€“ glycol humectant

Secondary Functions: Tewl reduction,skin plumping

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%โ€“10%

SOURCING & ETHICS

Vegan Status: Yes โ€“ synthetic

Halal Status: Yes

Source Notes: Synthetic or naturally derived. excellent aqueous solubility.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Ceramides,emollients,occlusives,glycerin,hyaluronic acid

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

K-beauty's preference for butylene glycol over propylene glycol is driven by two factors: bg's superior skin feel (less tacky than pg's higher viscosity) and its lower sensitization potential (1,3-bg has better spatial distribution of hydroxyl groups that reduces protein interaction vs pg's 1,2-position oh groups).

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

Dimethicone

Common Name(s): Pdms,polydimethylsiloxane,silicone fluid

CAS Number: 9006-65-9

DESCRIPTION

What It Does: Provides silicone-characteristic silky feel and skin protection with adjustable viscosity.

Why It's Used: The benchmark cosmetic silicone โ€“ sets the gold standard for silky application feel, spreadability, and skin protection in virtually all skin care categories.

How It Works: Polydimethylsiloxane chain flexibility provides extremely low surface tension and high spreadability. inert si-o backbone provides chemical stability and excellent skin tolerance. occlusive film formation reduces tewl. higher viscosity grades provide more intense conditioning.

Typically Found In: Moisturizers,foundations,primers,sunscreens โ€“ nearly universal

TECHNICAL DETAILS

Primary Category: Functional ingredient โ€“ polydimethylsiloxane

Secondary Functions: Barrier sealing,softening

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%โ€“30%

SOURCING & ETHICS

Vegan Status: Yes โ€“ synthetic

Halal Status: Yes

Source Notes: Plant-derived, synthetic or animal-derived. verify source.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low

Comedogenicity Rating: 1/5 โ€“ low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Dimethicone's exceptional silky feel arises from its very low intermolecular attractive forces (weak van der waals forces due to non-polar methyl groups) that allow silicone chains to slide freely over skin. the coefficient of kinetic friction for pdms against skin (~0.04) is among the lowest of any cosmetic material โ€“ explaining why even small amounts transform product feel.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

Glycerin

Common Name(s): Glycerol,glycerine,1,2,3-propanetriol

CAS Number: 56-81-5

DESCRIPTION

What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.

Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.

How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.

Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners

TECHNICAL DETAILS

Primary Category: Humectant

Secondary Functions: Skin barrier support,emollient,solvent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%โ€“30% (typical: 3โ€“10%)

SOURCING & ETHICS

Vegan Status: Yes โ€“ plant-derived (coconut, soy, palm) or synthetic

Halal Status: Yes โ€“ when plant-derived or synthetic; verify source with supplier

Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 โ€“ very low; non-irritating at all standard concentrations

Comedogenicity Rating: 0/5 โ€“ non-comedogenic

Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).

Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas

Avoid Combining With: No known incompatibilities at standard concentrations

SCIENTIFIC NOTE

Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder

Primary Sources: 2026-03-12