Clean Bee

DESCRIPTION

What It Does: Provides antioxidant protection, soothing anti-inflammatory effects, and skin-conditioning benefits through plant-derived polyphenols and phytochemicals.

Why It's Used: Plant extracts concentrate bioactive phytochemicals evolved for environmental protection — uv, microbial, and oxidative stressors — that translate to skin benefits.

How It Works: Polyphenols (flavonoids, phenolic acids) inhibit nf-κb-mediated inflammatory signaling, scavenge reactive oxygen species through electron donation, and chelate pro-oxidant metal ions to reduce oxidative skin damage.

Typically Found In: Serums,toners,moisturizers,masks,essences

TECHNICAL DETAILS

Primary Category: Botanical extracts

Secondary Functions: Antioxidant,anti-inflammatory

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1–10%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract; no animal components.

SKIN COMPATIBILITY

Irritancy Rating: 1899-12-31 00:00:00 -0800

Sensitivity Concerns: Low sensitization potential at recommended use concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Well-characterized cosmetic ingredient with established safety profile. generally non-irritating at typical use concentrations. suitable for leave-on and rinse-off cosmetics.

Works Well With: Niacinamide,hyaluronic acid,vitamin c,ceramides

Avoid Combining With: Strong oxidizing agents

SCIENTIFIC NOTE

Plant secondary metabolites (flavonoids, terpenes, phenolic acids) are biosynthesized as defense compounds against uv, herbivores, and pathogens. their anti-inflammatory activity typically derives from competitive inhibition of cox-2 and 5-lox enzymes (ic50 1–50 µm), while antioxidant activity involves single electron transfer (set) and hydrogen atom transfer (hat) mechanisms with structure-dependent rate constants.

Last Verified: Cosing eu database; pcpc cosmetic ingredient safety reviews; phytochemical and ethnobotanical literature

Primary Sources: 2025-01-15

DESCRIPTION

What It Does: Provides amphoteric foaming and conditioning with excellent compatibility across surfactant systems.

Why It's Used: Premium amphoteric surfactant for mild foaming shampoos and cleansers requiring broad surfactant compatibility and improved skin and eye tolerance vs capb alternatives.

How It Works: Amphoteric sultaine (internal zwitterion from quaternary ammonium + sulfonate) provides: foam stability and enhancement; antistatic conditioning on hair; mildness enhancement reducing ionic surfactant irritation; viscosity building with salt addition. superior eye tolerance vs capb (betaine).

Typically Found In: Baby shampoos,mild cleansers,eye-safe products

TECHNICAL DETAILS

Primary Category: Functional ingredient – amphoteric surfactant

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 2%–10%

SOURCING & ETHICS

Vegan Status: Yes – from coconut fatty acid chain

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Cocamidopropyl hydroxysultaine's superior eye tolerance vs capb arises from its sultaine rather than betaine zwitterionic head group. the sulfonate anion (so3⁻ in sultaine) is a stronger acid group than the carboxylate (coo⁻ in betaine), providing greater charge neutralisation and better interaction with tear film proteins — the molecular basis for its improved eye irritation profile in baby and sensitive-eye formulations.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides gentle non-ionic cleansing from natural glucose-derived surfactant chemistry.

Why It's Used: Leading natural-origin surfactant for green/natural formulations requiring gentle, non-ionic cleansing with excellent biodegradability credentials.

How It Works: Non-ionic surfactant with glucoside headgroup and decyl (c10) chain provides mild cleansing via micelle formation. non-ionic character provides lower irritation potential than anionic surfactants. fully biodegradable and from renewable sources.

Typically Found In: Natural cleansers,baby products,green beauty formulas,scalp cleansers

TECHNICAL DETAILS

Primary Category: Functional ingredient – alkyl glucoside surfactant

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 2%–20%

SOURCING & ETHICS

Vegan Status: Yes – from glucose (plant) and fatty alcohols

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Alkyl glucosides' (apgs) non-ionic character means they have no electrical charge that could interact with skin surface proteins and phospholipids – a key reason for their exceptional mildness. ionic surfactants (sulfates, carboxylates) bind to positively charged protein lysine/arginine residues causing denaturation; apgs have no such binding affinity.

Last Verified: Cosing database,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Activates cb2 cannabinoid receptors through alkylamide compounds providing anti-inflammatory immunomodulation, delivers antioxidant protection from echinacoside and cichoric acid polyphenols, and promotes wound healing through immune cell activation.

Why It's Used: Echinacea alkylamides are cb2 receptor agonists (kd ~0.1-1 μm) — the same endocannabinoid pathway as beta-caryophyllene — providing genuine receptor-mediated immunomodulation supporting the centuries of documented wound healing and anti-inflammatory traditional use.

How It Works: Echinacea n-alkylamides (e.g., n-(2-methylbutyl)-2e,4e,8z,10e/z-dodecatetraenamide) activate cb2 receptors on skin macrophages and mast cells → inhibition of tnf-α, il-6 → anti-inflammatory immune modulation. echinacoside (hydroxycinnamic acid glycoside) provides radical scavenging ic50 ~0.1 mg/ml. wound healing from activated macrophage vegf release.

Typically Found In: Anti-inflammatory,wound healing,immunomodulating

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–5%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Echinacea species specificity: e. purpurea provides highest alkylamide content (cb2 agonist); e. angustifolia provides highest echinacoside content (antioxidant); e. pallida provides highest polysaccharide content (immunomodulation). species selection depends on target mechanism.

Last Verified: Cosing database,echinacea alkylamide cb2 anti-inflammatory immunomodulating review

Primary Sources: 2026-03-22

DESCRIPTION

What It Does: Glycerin pulls water from the environment and deeper skin layers into the outer skin layer (epidermis), boosting moisture levels and keeping skin soft, smooth, and plump.

Why It's Used: It is used in virtually every moisturizer, serum, and cleanser because it is highly effective at hydrating skin, is well-tolerated by all skin types, and enhances the texture and spreadability of formulations.

How It Works: As a humectant, glycerin forms hydrogen bonds with water molecules, trapping them in the skin. it also reinforces the skin barrier by integrating into lipid structures between skin cells.

Typically Found In: Moisturizers,serums,cleansers,toners,sheet masks,sunscreens,body lotions,shampoos,conditioners

TECHNICAL DETAILS

Primary Category: Humectant

Secondary Functions: Skin barrier support,emollient,solvent

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 1%–30% (typical: 3–10%)

SOURCING & ETHICS

Vegan Status: Yes – plant-derived (coconut, soy, palm) or synthetic

Halal Status: Yes – when plant-derived or synthetic; verify source with supplier

Source Notes: Derived from plant oils via hydrolysis or saponification; synthetic versions also available. palm-derived glycerin carries sustainability concerns.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low; non-irritating at all standard concentrations

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Extremely rare allergic reactions; generally safe for all skin types including sensitive and baby skin

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Widely recognized as safe. ewg hazard score: 1. no significant concerns for irritation, sensitization, or toxicity at typical concentrations (up to 50%).

Works Well With: Hyaluronic acid,ceramides,niacinamide,panthenol,urea,peptides,retinol,ahas/bhas

Avoid Combining With: No known incompatibilities at standard concentrations

SCIENTIFIC NOTE

Glycerin is an endogenous skin component found naturally in the stratum corneum. aquaporin-3 channels in keratinocytes facilitate glycerin transport, making it integral to natural skin hydration pathways.

Last Verified: Cosing database,cir safety assessment,ewg skin deep,inci decoder

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Hydrogenated starch hydrolysate has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,hydrogenated starch hydrolysate technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Provides mild, naturally-derived cleansing with excellent biodegradability from glucose and lauryl alcohol.

Why It's Used: The natural cleansing standard — lauryl glucoside's combination of renewability, biodegradability, mildness, and foaming makes it the benchmark natural surfactant for clean beauty facial cleansers.

How It Works: C12 alkyl chain provides cmc and foaming. glucose head group provides mild non-ionic/weakly anionic character from hydroxyl groups. very low irritation potential from polyol head group. excellent biodegradability >95% bod28 from glucoside hydrolysis. cosmos approved.

Typically Found In: Natural facial cleansers,baby shampoos,cosmos certified products

TECHNICAL DETAILS

Primary Category: Functional ingredient – alkyl glucoside surfactant

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 2%–15%

SOURCING & ETHICS

Vegan Status: Yes – from corn glucose + coconut lauryl alcohol

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Lauryl glucoside's mildness vs sls at equivalent foam performance is measurable by draize eye score: sls scores approximately 55 (mild irritant) while lauryl glucoside scores <15 (essentially non-irritant) in identical eye irritation testing. this quantitative mildness advantage explains why apg surfactants command premium pricing despite renewable/natural origin — actual performance superiority justifies the cost.

Last Verified: Cosing database,cosmos standard,cir safety assessment

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Maltooligosyl glucoside has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,maltooligosyl glucoside technical literature

Primary Sources: 2026-03-12

DESCRIPTION

What It Does: Delivers characteristic cosmetic function at recommended use concentration.

Why It's Used: Selected for functional contribution and formulation compatibility supported by cosmetic science and regulatory safety data.

How It Works: Works through the mechanism of its molecular class — physicochemical or biological interaction with skin proteins, lipids, or receptors as documented in peer-reviewed cosmetic literature.

Typically Found In: Skin care formulations

TECHNICAL DETAILS

Primary Category: Active ingredient – cosmetic active

Secondary Functions: Skin conditioning

Application Areas:

Facial Skincare

Body Care

Hair Care

Beard Care

Color Cosmetics (Makeup)

Dietary/Oral Supplements

Typical Concentration Range: 0.1%–10%

SOURCING & ETHICS

Vegan Status: Conditional

Halal Status: Yes

Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Well-tolerated by most skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.

Works Well With: Standard skincare actives

Avoid Combining With: No known significant incompatibilities

SCIENTIFIC NOTE

Sodium lauroyl methyl isethionate has an established safety and efficacy profile within the cosmetic regulatory framework at standard use concentrations.

Last Verified: Cosing database,sodium lauroyl methyl isethionate technical literature

Primary Sources: 2026-03-12