Common Name(s): Teprenone,teprenone,geranylgeranylacetone,heat shock protein inducer
CAS Number: N/a
DESCRIPTION
What It Does: Provides hsp70 molecular chaperone induction for cellular protein quality control, protecting skin proteins from aggregation and degradation under uv and oxidative stress conditions.
Why It's Used: Teprenone is selected for its unique heat shock protein induction mechanism — hsp70 induction provides a cellular stress-resistance anti-aging benefit that antioxidants and peptides cannot provide, protecting the skin's own protein machinery from damage.
How It Works: Teprenone → hsf1 (heat shock factor 1) transcription factor activation → hsp70 gene expression → hsp70 molecular chaperone → protein aggregate prevention + misfolded protein refolding → cellular anti-aging.
Typically Found In: Anti-aging,cellular protection
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%–2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Teprenone was developed as a gastroprotective drug (selbex) before its hsp70-inducing anti-aging skin activity was identified — providing robust pharmaceutical-grade safety documentation.
Last Verified: 2026-03-22
Primary Sources: Cosing database,teprenone geranylgeranylacetone hsp70 anti-aging review