Common Name(s): Sodium sulfated hyaluronate,sodium sulfated hyaluronate,sulfated ha,heparin-mimetic hyaluronate
CAS Number: N/a
DESCRIPTION
What It Does: Provides standard hyaluronate humectancy plus heparin-mimetic sulfate group fgf growth factor binding and anti-inflammatory activity from the added sulfate ester groups.
Why It's Used: Sodium sulfated hyaluronate is selected over standard ha for its dual humectant and heparin-mimetic pharmacology — sulfation adds fgf-binding sulfate groups to the ha backbone, creating a single molecule that hydrates while simultaneously binding and stabilising growth factors for accelerated wound healing and anti-aging.
How It Works: Sulfated ha: ha backbone → water-binding humectancy; sulfate groups → fgf/tgf-β electrostatic binding → growth factor stabilisation; anti-inflammatory complement inhibition → reduced hypersensitivity.
Typically Found In: Moisturiser,wound healing,anti-aging
TECHNICAL DETAILS
Primary Category: Active ingredient – humectant
Secondary Functions: Moisture retention,hydration
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–5%
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Plant-derived or fermentation-produced. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; suitable for sensitive skin.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,emollients,occlusives,barrier actives
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Sulfation degree (ds) determines the balance between ha humectancy and heparin-mimetic activity — low ds preserves ha properties while high ds provides dominant heparin-like pharmacology.
Last Verified: 2026-03-22
Primary Sources: Cosing database,sodium sulfated hyaluronate heparin-mimetic ha review