Common Name(s): Sodium cyclic lysophosphatidic acid,sodium cyclic lysophosphatidic acid,lpa receptor agonist sodium salt,dermal matrix stimulating lipid
CAS Number: N/a
DESCRIPTION
What It Does: Activates lpa1 and lpa3 receptors on dermal fibroblasts to upregulate col1a1, elastin, and has2 synthesis, stimulates keratinocyte renewal through lpa receptor-mediated proliferation, and promotes wound healing from fibroblast migration and matrix remodelling.
Why It's Used: Cyclic lpa provides lpa receptor activation with improved metabolic stability — the cyclic phosphate ring resists phospholipase degradation providing 5–10× longer skin half-life than linear lpa while retaining equivalent lpa1/3 receptor binding affinity.
How It Works: Na-clpa binds lpa receptor subtypes (lpa1, lpa3) at the plasma membrane → gi/gq coupling → pi3k-akt cell survival + rho-rock fibroblast cytoskeletal reorganisation + erk proliferation. has2 upregulation → increased hyaluronic acid synthesis; col1a1 → increased type i collagen; elastin → improved skin elasticity.
Typically Found In: Premium anti-aging,dermal matrix support
TECHNICAL DETAILS
Primary Category: Active ingredient – cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%–0.1%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Clpa is found naturally in fermented foods (natto, miso, sake) at trace concentrations — its occurrence in traditional japanese fermented foods provides natural heritage alongside the documented lpa receptor pharmacology for skin anti-aging.
Last Verified: 2026-03-22
Primary Sources: Cosing database,sodium cyclic lpa receptor agonist dermal matrix anti-aging review