Common Name(s): C16-26 hydroxyalkanoyl sphingadienes,c16-26 hydroxyalkanoyl sphingadienes,ceramide precursor sphingolipid,sc barrier integration active

CAS Number: N/a

DESCRIPTION

What It Does: Integrates into sc lamellar lipid bilayers as ceramide structural analogues — restoring the ceramide fraction depleted in dry and atopic skin to reduce tewl and improve barrier function.

Why It's Used: Sphingadiene ceramide precursors provide the most direct sc barrier integration of any botanical emollient — the ceramide-mimetic architecture enabling genuine lamellar bilayer participation rather than surface-only occlusion.

How It Works: C16-26 hydroxyalkanoyl sphingadienes: the amide bond and trans-4,14-sphingadiene backbone mimic ceramide's hydrogen-bonding geometry for sc lamellar orthorhombic crystal phase integration. the c16-c26 chain length distribution matches the ceramide chain length distribution in healthy sc for optimal phase compatibility.

Typically Found In: Barrier repair,eczema care,ceramide skin care

TECHNICAL DETAILS

Primary Category: Functional ingredient – emollient

Secondary Functions: Barrier sealing,softening

Application Areas:

Typical Concentration Range: 0.1%–3%

SOURCING & ETHICS

Vegan Status: Conditional - supplier confirmation required

Halal Status: Unverified - supplier confirmation required

Source Notes: Plant-derived, synthetic or animal-derived. verify source. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 1/5 – low; formulation-dependent

Sensitivity Concerns: Non-irritating.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Humectants,ceramides,actives as carrier

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Sphingadiene ceramide precursors are found naturally in sea buckthorn (hippophae rhamnoides) and rice bran — the plant-derived chain length distribution closely matches human sc ceramide chain lengths for optimal barrier integration without chain-length mismatch.

Last Verified: 2026-03-22

Primary Sources: Cosing database,hydroxyalkanoyl sphingadiene ceramide precursor sc barrier review