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Advanced Glycation Endproduct (AGE)

Description

Advanced Glycation Endproducts (AGEs) are complex compounds formed when proteins or lipids become glycated as a result of exposure to sugars. This process, known as the Maillard reaction, occurs naturally in the body but accelerates with aging and in certain disease states. In the context of skin health, AGEs play a significant role in the degradation of collagen and elastin, leading to premature aging and reduced skin elasticity.

AGEs form cross-links between proteins, particularly affecting long-lived proteins such as collagen in the dermis. This cross-linking alters the structural and functional properties of skin tissues, contributing to wrinkle formation, loss of skin firmness, and compromised barrier function. Additionally, AGEs can trigger inflammation and oxidative stress through interaction with specific receptors (RAGEs), further exacerbating skin damage.

The accumulation of AGEs in skin is influenced by both intrinsic factors, such as natural aging and genetics, and extrinsic factors, including UV exposure, pollution, and dietary habits. High-sugar diets and smoking are known to accelerate AGE formation. In skincare formulations, ingredients that inhibit AGE formation or break existing cross-links are of particular interest for their potential anti-aging benefits.