Common Name(s): Zederone,zederone,ginger family sesquiterpene,anti-inflammatory ketone
CAS Number: N/a
DESCRIPTION
What It Does: Provides guaiane sesquiterpene ketone anti-inflammatory activity through nf-kb inhibition and prostaglandin biosynthesis modulation.
Why It's Used: Zederone is selected for the unique guaiane sesquiterpene ketone anti-inflammatory scaffold of curcuma zedoaria — providing distinct anti-inflammatory pharmacology from the curcuminoids of standard turmeric, complementing the curcumin mechanism with sesquiterpene nf-kb modulation.
How It Works: Zederone bicyclic guaiane → nf-kb p65 nuclear translocation inhibition → reduced il-1β/il-6/tnf-α; alpha,beta-unsaturated ketone → michael acceptor activity; anti-proliferative via cdk inhibition.
Typically Found In: Anti-inflammatory,anti-aging
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.05%–2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Zederone is the pharmacologically active sesquiterpene marker compound of curcuma zedoaria — standardisation to zederone content is the quality marker for white turmeric extracts.
Last Verified: 2026-03-22
Primary Sources: Cosing database,zederone guaiane sesquiterpene curcuma zedoaria review