Common Name(s): Aa2g,ascorbic acid 2-glucoside,ascorbyl-2-glucoside

CAS Number: 129499-78-1

DESCRIPTION

What It Does: Provides sustained, stable vitamin c activity in skin through slow enzymatic release of l-ascorbic acid.

Why It's Used: Most stable vitamin c form available – suitable for formulations requiring 12-24 month shelf-life stability with full vitamin c brightening activity.

How It Works: Glucoside bond at 2-position protects the most oxidation-sensitive lactone oxygen. glucosidase enzymes in skin hydrolyze the glycoside bond releasing free l-ascorbic acid over 12-24 hours, providing sustained vitamin c activity.

Typically Found In: Stable brightening serums,long-shelf-life formulas,travel skincare

TECHNICAL DETAILS

Primary Category: Active ingredient – glucoside vitamin c form

Secondary Functions: Maximum stability vitamin c,sustained release

Application Areas:

Typical Concentration Range: 2%–10%

SOURCING & ETHICS

Vegan Status: Yes – enzymatic synthesis from l-ascorbic acid and glucose

Halal Status: Yes

Source Notes: Synthetically produced vitamin c derivative.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; suitable for all skin types.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Tocopherol,ferulic acid,niacinamide,spf

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Aa-2g's enzymatic synthesis creates a 2-o-alpha-glucoside bond that protects the c2 hydroxyl (the site of initiation of ascorbic acid oxidation), providing dramatically greater stability than all other vitamin c forms. hplc studies show <5% degradation of aa-2g in emulsions over 12 months vs >50% degradation of l-ascorbic acid under equivalent conditions.

Last Verified: 2026-03-12

Primary Sources: Cosing database,hayashi et al. aa-2g stability study,cir safety assessment