Common Name(s): Tripotassium ursolyl phosphate,tripotassium ursolyl phosphate,ursolic acid phosphate,water-soluble triterpenoid

CAS Number: N/a

DESCRIPTION

What It Does: Provides ursolic acid triterpenoid nf-kb anti-inflammatory, mmp-1 collagenase inhibitory, and 5-alpha reductase sebum regulatory activity in a water-soluble phosphate ester format.

Why It's Used: Tripotassium ursolyl phosphate is selected for ursolic acid's multi-target triterpenoid pharmacology in aqueous-compatible form — the phosphate esterification solves ursolic acid's fundamental water insolubility without the high co-solvent loading that limits free ursolic acid in emulsion formulas.

How It Works: Ursolyl phosphate → phosphatase hydrolysis at skin surface → ursolic acid → nf-kb iκb kinase inhibition + mmp-1 competitive inhibition + 5α-reductase inhibition → simultaneous anti-inflammatory, anti-aging, anti-acne.

Typically Found In: Anti-aging,anti-acne,anti-inflammatory

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.1%–3%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Phosphate ester hydrolysis by alkaline phosphatase provides controlled release of ursolic acid — the enzyme activity at the skin surface converts the pro-drug to the active triterpenoid.

Last Verified: 2026-03-22

Primary Sources: Cosing database,tripotassium ursolyl phosphate water-soluble triterpenoid review