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TRIFLUOROMETHYLPHENETHYL MESALAZINE

Description

Trifluoromethylphenethyl mesalazine is an innovative compound that combines the anti-inflammatory properties of mesalazine with enhanced skin penetration capabilities. This synthetic molecule is designed to target dermatological conditions, particularly those involving inflammation and oxidative stress.

The compound consists of mesalazine, a well-established anti-inflammatory agent, linked to a trifluoromethylphenethyl group. This modification significantly improves the molecule's lipophilicity, allowing for better absorption through the stratum corneum and increased bioavailability in deeper skin layers.

Trifluoromethylphenethyl mesalazine exhibits potent anti-inflammatory effects by inhibiting key inflammatory mediators such as prostaglandins and leukotrienes. It also demonstrates antioxidant properties, neutralizing free radicals and reducing oxidative damage in skin cells.

Clinical studies have shown promising results in treating various skin disorders, including psoriasis, atopic dermatitis, and contact dermatitis. The compound has demonstrated a favorable safety profile with minimal systemic absorption, reducing the risk of systemic side effects associated with traditional oral medications.

Formulations containing trifluoromethylphenethyl mesalazine are typically available as topical creams, ointments, or gels, allowing for targeted application to affected areas. The compound's stability and compatibility with common excipients make it suitable for incorporation into various skincare products.