Common Name(s): Triacetyl retinoyl phytosphingosine,triacetyl retinoyl phytosphingosine,retinoid-ceramide conjugate,dual anti-aging
CAS Number: N/a
DESCRIPTION
What It Does: Provides simultaneous retinoid rar anti-aging gene activation and phytosphingosine ceramide biosynthesis pathway support from a single conjugate molecule.
Why It's Used: Triacetyl retinoyl phytosphingosine is selected for its dual-mechanism molecular architecture — the retinoyl moiety activates rar anti-aging genes while the phytosphingosine backbone replenishes sc sphingoid base for ceramide synthesis, addressing two independent anti-aging deficits simultaneously.
How It Works: Triacetyl retinoyl phytosphingosine → sc esterase/acetylase hydrolysis → retinoic acid (rar activation) + phytosphingosine (ceramide biosynthesis substrate) — dual release from single conjugate.
Typically Found In: Anti-aging,barrier repair,premium skin care
TECHNICAL DETAILS
Primary Category: Active ingredient – cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%–1%
SOURCING & ETHICS
Vegan Status: Conditional - feedstock declaration required
Halal Status: Unverified - feedstock declaration required (plant, animal and petrochemical routes all exist)
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: origin-dependent: the same inci exists in plant, animal and petrochemical versions and the name does not discriminate. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1–2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
The conjugate approach reduces retinoid irritancy — phytosphingosine barrier repair co-delivery mitigates the retinoid irritation response by simultaneously strengthening the sc barrier being challenged.
Last Verified: 2026-03-22
Primary Sources: Cosing database,triacetyl retinoyl phytosphingosine retinoid ceramide conjugate review