Common Name(s): Tetracarboxymethyl dipeptide-12,tetracarboxymethyl dipeptide-12,carboxymethyl-chelating dipeptide,anti-aging signal peptide
CAS Number: N/a
DESCRIPTION
What It Does: Stimulates fibroblast collagen i, iii, iv synthesis and inhibits mmp-1/mmp-3 collagen degradation — providing clinically measurable wrinkle reduction and skin firmness improvement with regular use.
Why It's Used: Precision peptide pharmacology provides mechanism-based anti-aging efficacy — the defined sequence targeting specific receptors (tgf-beta, egf, integrin) enables quantifiable binding kinetics and reproducible clinical outcomes.
How It Works: Peptide sequence binds cognate receptor activating map kinase or smad cascades → col1a1/col3a1 upregulation and mmp-1/mmp-3 downregulation. carboxymethyl groups chelate zn2+ in mmp active sites providing dual sequence-receptor + enzyme inhibition.
Typically Found In: Anti-aging serums,collagen products
TECHNICAL DETAILS
Primary Category: Active ingredient – peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1–5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Peptide sequence purity above 98% is essential for reliable receptor binding — single amino acid substitution can eliminate binding selectivity. spps synthesis and hplc purification are the quality standards for efficacious cosmetic peptides.
Last Verified: 2026-03-22
Primary Sources: Cosing database,tetracarboxymethyl dipeptide-12 signal peptide review