Common Name(s): Sophocarpine,sophocarpine,quinolizidine alkaloid,anti-inflammatory active

CAS Number: N/a

DESCRIPTION

What It Does: Provides quinolizidine alkaloid anti-inflammatory activity through nf-kb and mapk pathway inhibition, with anti-pruritic activity through trpv1 channel modulation.

Why It's Used: Sophocarpine is selected for its quinolizidine scaffold anti-inflammatory mechanism — the alkaloid provides a distinct nf-kb inhibition mechanism from conventional polyphenol or terpenoid anti-inflammatories, with clinical validation in atopic and inflammatory skin conditions.

How It Works: Sophocarpine → nf-kb p65 nuclear translocation inhibition → reduced tnf-α/il-1β/il-6; trpv1 modulation → reduced itch signal; mapk jnk inhibition → keratinocyte normalisation.

Typically Found In: Anti-inflammatory,sensitive skin,anti-itch

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.05%–2%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Sophocarpine is the pharmacologically active alkaloid in sophora extracts — standardisation to sophocarpine content is the quality marker for this ingredient class.

Last Verified: 2026-03-22

Primary Sources: Cosing database,sophocarpine quinolizidine alkaloid anti-inflammatory review