Common Name(s): Sodium pantetheine sulfonate,sodium pantetheine sulfonate,pantetheine derivative,coa precursor antioxidant

CAS Number: N/a

DESCRIPTION

What It Does: Provides pantetheine-pathway coa precursor activity for acetyl-coa energy metabolism and antioxidant fatty acid synthesis in skin.

Why It's Used: Sodium pantetheine sulfonate is selected as a stabilised water-soluble coa precursor — the sulfonate modification provides oxidative stability over free pantetheine while retaining the cysteamine thiol chemistry for coa biosynthesis.

How It Works: Pantetheine sulfonate → hydrolysis → pantetheine → phosphorylation → 4'-phosphopantetheine → coa; coa → acetyl-coa energy metabolism + fatty acid synthesis.

Typically Found In: Antioxidant skin care

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.1%–3%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Pantetheine sulfonate is more stable than pantetheine in aqueous formulation — the sulfonate group prevents oxidative dimerisation to pantethine.

Last Verified: 2026-03-22

Primary Sources: Cosing database,sodium pantetheine sulfonate coa precursor review