Common Name(s): Sodium fructoborate,sodium fructoborate,organoboron anti-aging,nf-kb inhibitor antioxidant
CAS Number: N/a
DESCRIPTION
What It Does: Provides anti-inflammatory activity through boron's nf-kb inhibition, antioxidant protection from diol-borate complex formation reducing oxidative catalysis, and skin conditioning from the fructose-borate ester's sc-compatible chemistry.
Why It's Used: Sodium fructoborate is the only natural organoboron compound with documented nf-kb inhibitory activity — the boron atom's unique lewis acid geometry provides protein-boron interactions that no organic phytochemical can replicate.
How It Works: Fructoborate boron acts as a lewis acid forming reversible covalent bonds with 1,2-diol groups on proteins — specifically inhibiting iκb kinase by boron coordination to the active site ser180/ser181 phosphorylation sites, blocking nf-κb nuclear translocation. simultaneously, boron chelates catechol/diol ros-generating species reducing fenton-type radical production.
Typically Found In: Anti-inflammatory,anti-aging,antioxidant
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%–1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Dietary boron intake is associated with reduced inflammatory markers and improved bone density — sodium fructoborate provides the same organoboron chemistry for topical anti-inflammatory skin care application.
Last Verified: 2026-03-22
Primary Sources: Cosing database,sodium fructoborate organoboron nf-kb anti-inflammatory review