Common Name(s): Rhigf-1,recombinant insulin-like growth factor-1

CAS Number: N/a

DESCRIPTION

What It Does: Stimulates skin cell proliferation and collagen synthesis through igf-1 receptor signaling that declines with age.

Why It's Used: Advanced anti-aging targeting the age-related decline in igf-1 signaling that contributes to reduced skin regeneration capacity.

How It Works: Binds igf-1 receptor activating pi3k/akt and ras/mapk signaling pathways for fibroblast and keratinocyte proliferation, collagen synthesis, and cell survival.

Typically Found In: Advanced anti-aging serums,regenerative skincare

TECHNICAL DETAILS

Primary Category: Active ingredient – recombinant human igf-1

Secondary Functions: Igf-1 receptor activation,cell proliferation,anabolic signaling

Application Areas:

Typical Concentration Range: 0.001%–0.01%

SOURCING & ETHICS

Vegan Status: Conditional – often biotechnology-derived

Halal Status: Conditional – verify production method

Source Notes: Produced by recombinant dna technology. pharmaceutical/biotechnology grade.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile at cosmetic concentrations. ewg score: 1.

Works Well With: Hyaluronic acid,ceramides,peptides,antioxidants

Avoid Combining With: Avoid with harsh ahas that may denature protein structure

SCIENTIFIC NOTE

Plasma and local igf-1 levels decline approximately 14% per decade after age 30. this igf-1 decline reduces fibroblast proliferation and collagen synthesis rates, contributing directly to the reduced dermal thickness and wrinkle formation observed in aging skin.

Last Verified: 2026-03-12

Primary Sources: Cosing database,smith et al. igf-1 skin aging review