Common Name(s): Schizophyllum commune mycelium,schizophyllum commune mycelium,split gill mushroom,beta-glucan immune modulator
CAS Number: N/a
DESCRIPTION
What It Does: Provides schizophyllan beta-glucan dectin-1 receptor activation for skin innate immunity modulation, anti-inflammatory cytokine regulation, and prebiotic microbiome support.
Why It's Used: Schizophyllum commune mycelium is selected for its schizophyllan beta-glucan — the triple-helix beta-1,3/1,6-glucan from schizophyllum provides uniquely potent dectin-1 activation for skin innate immunity support, with pharmaceutical validation from its use as a biological response modifier in japan.
How It Works: Schizophyllan triple-helix beta-glucan → dectin-1 receptor binding → card9/bcl10 signalling → nk cell and macrophage activation → anti-microbial immunity; nf-kb modulation → balanced inflammatory response.
Typically Found In: Microbiome skin care,immunity support
TECHNICAL DETAILS
Primary Category: Active ingredient – skin microbiome support
Secondary Functions: Microbiome balance,prebiotic effect
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%–5%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Fermentation-derived or plant-extracted.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; beneficial for sensitive skin.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Ceramides,niacinamide,soothing actives
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Schizophyllan's triple-helix secondary structure is critical for dectin-1 activity — heating disrupts the helix and reduces immunomodulatory potency, requiring cold processing.
Last Verified: 2026-03-22
Primary Sources: Cosing database,schizophyllum commune mycelium schizophyllan beta-glucan review