Common Name(s): Rubusoside,rubusoside,diterpene glycoside sweetener,bitter masking anti-inflammatory active
CAS Number: N/a
DESCRIPTION
What It Does: Masks bitter taste of cosmetic ingredients in oral care and edible cosmetics, provides anti-inflammatory activity from the ent-kauranoid diterpene nf-kb inhibition, and delivers antioxidant protection from the glycoside radical scavenging.
Why It's Used: Rubusoside's intense sweetness (200ร sucrose) provides bitter-masking in oral care formulations while the diterpene aglycone provides genuine anti-inflammatory skin activity โ rare dual oral-sensory and topical-therapeutic functionality.
How It Works: Rubusoside ent-kaurane diterpene skeleton inhibits nf-kb through iฮบb kinase interaction analogous to other terpenoid nf-kb inhibitors. the glucoside moieties (two glucose units) provide water solubility for skin delivery and protect the diterpene from rapid oxidation. bitter masking from t2r bitter receptor competitive antagonism.
Typically Found In: Anti-inflammatory,oral care,bitter masking
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Rubusoside's origin as a natural high-intensity sweetener (from chinese sweet tea, rubus suavissimus) provides gras-adjacent safety documentation and fda sids review โ the extensive food safety data supporting its cosmetic application.
Last Verified: 2026-03-22
Primary Sources: Cosing database,rubusoside diterpene glycoside anti-inflammatory sweet tea review