Common Name(s): Rice sh-polypeptide-1,rice sh-polypeptide-1,rice-biomimetic oligopeptide,anti-aging signal peptide

CAS Number: N/a

DESCRIPTION

What It Does: Stimulates fibroblast collagen i, iii, iv synthesis and inhibits mmp-1/mmp-3 collagen degradation — providing clinically measurable wrinkle reduction and skin firmness improvement with regular use.

Why It's Used: Precision peptide pharmacology provides mechanism-based anti-aging efficacy — the defined sequence targeting specific receptors (tgf-beta, egf, integrin) enables quantifiable binding kinetics and reproducible clinical outcomes.

How It Works: Peptide sequence binds cognate receptor activating map kinase or smad cascades → col1a1/col3a1 upregulation and mmp-1/mmp-3 downregulation. spps synthesis provides >98% sequence purity for reproducible receptor binding.

Typically Found In: Anti-aging serums,collagen products

TECHNICAL DETAILS

Primary Category: Active ingredient – peptide

Secondary Functions: Collagen synthesis,anti-aging

Application Areas:

Typical Concentration Range: 1–5000 ppm

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating at recommended concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid

Avoid Combining With: Strong acids below ph 3.5; oxidising agents

SCIENTIFIC NOTE

Peptide sequence purity above 98% is essential for reliable receptor binding — single amino acid substitution can eliminate binding selectivity. spps synthesis and hplc purification are the quality standards for efficacious cosmetic peptides.

Last Verified: 2026-03-22

Primary Sources: Cosing database,rice sh-polypeptide-1 signal peptide review