Common Name(s): Riboflavin tetraacetate,riboflavin tetraacetate,riboflavin ester,acetylated vitamin b2
CAS Number: N/a
DESCRIPTION
What It Does: Provides riboflavin fad/fmn cofactor activity via rapid acetate hydrolysis, with acetyl groups providing moderate sc penetration enhancement over free riboflavin.
Why It's Used: Riboflavin tetraacetate occupies the middle ground between free riboflavin (low penetration) and tetrabutyrate (high penetration, slow hydrolysis) โ four acetate groups provide rapid sc esterase hydrolysis with improved lipid phase delivery.
How It Works: Riboflavin tetraacetate โ rapid sc esterase hydrolysis โ riboflavin โ fmn/fad cofactor pathway โ antioxidant enzyme support.
Typically Found In: Antioxidant skin care
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Acetate ester hydrolysis rate is significantly faster than butyrate โ tetraacetate provides a faster-onset riboflavin release profile.
Last Verified: 2026-03-22
Primary Sources: Cosing database,riboflavin tetraacetate vitamin b2 review