Common Name(s): Rh-polypeptide-83
DESCRIPTION
What It Does: Provides skin conditioning and anti-aging benefits from a recombinant human-sequence polypeptide.
Why It's Used: Used as a premium anti-aging active providing human-specific protein sequence activity.
How It Works: Rh (recombinant human) prefix indicates human-sequence recombinant protein; produced in bacterial or yeast expression systems; provides human-specific receptor interactions.
Typically Found In: Premium anti-aging serums
TECHNICAL DETAILS
Primary Category: Active ingredient – peptide
Secondary Functions: Anti-aging active,skin conditioning agent
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%–0.1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Recombinant human polypeptide from bacterial or yeast fermentation expression.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Generally well tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile. ewg score: 1.
Works Well With: Other peptides,growth factor analogs
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Recombinant human polypeptides (rh-prefix in inci) are produced by expressing the human protein sequence in microbial hosts; they provide human-specific protein activity without human tissue sourcing.
Last Verified: 2026-03-28
Primary Sources: Cosing database,inci dictionary