Common Name(s): Rh-polypeptide-13,rh-polypeptide-13,signal peptide,anti-aging active
CAS Number: N/a
DESCRIPTION
What It Does: Provides peptide sequence-specific receptor binding to modulate collagen synthesis, elastin production, or barrier gene expression for measurable anti-aging outcomes.
Why It's Used: Rh-polypeptide-13 delivers mechanism-based anti-aging activity through its specific amino acid pharmacophore — peptide length and sequence determining the precise receptor target and gene modulation pathway.
How It Works: Peptide synthesis (spps) → sequence-specific receptor binding → intracellular second messenger → gene expression modulation → collagen/elastin/barrier protein synthesis.
Typically Found In: Anti-aging,serum,eye care
TECHNICAL DETAILS
Primary Category: Active ingredient – peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%–2%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Peptide stability in formulation requires ph control (5.5–6.5) and chelation of trace metals that catalyse oxidative chain cleavage.
Last Verified: 2026-03-22
Primary Sources: Cosing database,rh-polypeptide-13 signal peptide review