Common Name(s): Resveratrol tripentyl ether,resveratrol tripentyl ether,lipophilic resveratrol ether,stable sc-penetrating sirt1 activator
CAS Number: N/a
DESCRIPTION
What It Does: Provides sirt1 sirtuin anti-aging pathway activation, antioxidant radical scavenging, and anti-inflammatory nf-kb modulation from resveratrol in a highly lipophilic ether form with superior formulation stability and sc penetration versus free resveratrol.
Why It's Used: Tri-o-alkyl resveratrol ethers are among the most stable resveratrol derivatives — unlike ester derivatives (hydrolysis in water), ether bonds are essentially hydrolysis-resistant providing indefinite aqueous formulation stability while the sc delivers the ether to tissue esterases/etherases for slow resveratrol release.
How It Works: Tripentyl ether: each pentyl group raises logp by ~0.9 units → total logp ~8 → maximum sc lipid bilayer partitioning → very deep dermis delivery. slow ether bond cleavage by skin microsomal o-dealkylases → free resveratrol → sirt1 deacetylase activation → pgc-1α → mitochondrial biogenesis → anti-aging. phenol groups from ether cleavage → radical scavenging + nf-kb inhibition.
Typically Found In: Premium anti-aging,sirt1 skin care,anhydrous products
TECHNICAL DETAILS
Primary Category: Active ingredient – antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%–1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Ether vs ester resveratrol stability: ether bonds (c-o-c) are 100-1000× more resistant to hydrolysis than ester bonds (c(=o)-o-c) — the tripentyl ether provides essentially complete aqueous stability versus the rapid hydrolysis of resveratrol diacetate/dipalmitate in water-containing formulations.
Last Verified: 2026-03-22
Primary Sources: Cosing database,resveratrol tripentyl ether stable sirt1 sc-penetrating review