Common Name(s): Rebaudioside a,rebaudioside a,steviol glycoside high-intensity sweetener,bitter masking anti-inflammatory active
CAS Number: N/a
DESCRIPTION
What It Does: Provides intense sweetness for oral care formulation palatability from t1r2/t1r3 sweet receptor activation, bitter masking of unpalatable active ingredients, and anti-inflammatory activity from the steviol ent-kauranoid diterpene backbone.
Why It's Used: Rebaudioside a's steviol diterpene aglycone shares the same ent-kauranoid skeleton as other anti-inflammatory diterpenes โ the same terpenoid scaffold providing nf-kb modulation while the sugar chains provide the intense sweetness.
How It Works: Reb a: four glucose units on steviol โ t1r2/t1r3 heterodimer sweet receptor activation โ sweet taste perception (200-400ร sucrose on molar basis). steviol ent-kauranoid aglycone (after intestinal/skin glucosidase hydrolysis) โ ikk-ฮฒ modulation โ mild nf-kb anti-inflammatory activity analogous to other ent-kauranoids.
Typically Found In: Oral care,bitter masking,anti-inflammatory
TECHNICAL DETAILS
Primary Category: Active ingredient โ cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ1%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Rebaudioside a regulatory: approved as food sweetener (eu e960, us gras) with extensive safety documentation supporting cosmetic application at equivalent concentrations. cosmos-approved natural alternative to synthetic sweeteners in oral care formulations.
Last Verified: 2026-03-22
Primary Sources: Cosing database,rebaudioside a steviol glycoside sweetener anti-inflammatory review