Common Name(s): Pyridoxine tris-hexyldecanoate,pyridoxine fatty acid ester,lipophilic vitamin b6,sc-penetrating anti-inflammatory

CAS Number: N/a

DESCRIPTION

What It Does: Delivers vitamin b6 into the sc lipid phase for sebum regulation through 5-alpha-reductase modulation, anti-inflammatory activity from pyridoxal-5-phosphate pathway involvement in prostaglandin metabolism, and improved skin condition from b6's essential coenzyme roles.

Why It's Used: The hexyldecanoate ester dramatically raises b6 logp from -0.77 to >8 — enabling sc penetration and sebaceous gland delivery of vitamin b6 for sebum-regulating activity unavailable from water-soluble pyridoxine that remains on the skin surface.

How It Works: Esterase hydrolysis in the sc releases free pyridoxine which is phosphorylated to pyridoxal-5-phosphate (plp) — the active b6 coenzyme form. plp is cofactor for transamination reactions in amino acid metabolism, sphingolipid biosynthesis (spt, the rate-limiting ceramide enzyme), and the prostaglandin pathway enzymes modulating sebum composition.

Typically Found In: Anti-acne,oily skin,anti-aging

TECHNICAL DETAILS

Primary Category: Active ingredient – antioxidant

Secondary Functions: Free radical scavenging,anti-aging

Application Areas:

Typical Concentration Range: 0.1%–2%

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Plant-derived extract or synthetic.

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating; well-tolerated.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants

Avoid Combining With: No significant incompatibilities

SCIENTIFIC NOTE

Sphingosine phosphotransferase (spt) requires pyridoxal-5-phosphate as an obligatory cofactor for ceramide biosynthesis — b6 delivery to the sc directly supports the ceramide production rate essential for barrier function.

Last Verified: Cosing database,pyridoxine tris-hexyldecanoate lipophilic b6 sc penetration review

Primary Sources: 2026-03-22