Common Name(s): Pyridoxine glycyrrhetinate,pyridoxine glycyrrhetinate,vitamin b6 glycyrrhetinic acid conjugate,anti-inflammatory metabolic dual active
CAS Number: N/a
DESCRIPTION
What It Does: Provides pyridoxine vitamin b6 amino acid metabolism support alongside glycyrrhetinic acid 11-beta-hsd1 anti-inflammatory cortisol modulation โ the dual mechanism combining skin metabolic support with targeted anti-inflammatory activity from one conjugate.
Why It's Used: B6-glycyrrhetinate conjugation provides complementary dual-mechanism activity โ b6 supports the skin's amino acid metabolic capacity while glycyrrhetinic acid modulates the cortisol-mediated inflammation; the conjugate delivers both to the same tissue simultaneously.
How It Works: Conjugate hydrolysis โ pyridoxine + glycyrrhetinic acid. pyridoxine โ plp (pyridoxal kinase) โ transaminase cofactor โ amino acid metabolism support. glycyrrhetinic acid โ 11ฮฒ-hsd1 inhibition (ic50 ~0.5 ฮผm) โ reduced local cortisol โ anti-inflammatory. glycyrrhetinate ester cleavage provides controlled release of both components.
Typically Found In: Anti-inflammatory,anti-aging,metabolic support
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Conjugation stability: the ester bond between pyridoxine and glycyrrhetinic acid hydrolyses at acidic ph โ formulate at ph 5.5-7 for optimal shelf life. the ester hydrolysis at skin ph 5 provides controlled in-situ release of the active components.
Last Verified: Cosing database,pyridoxine glycyrrhetinate b6 glycyrrhetinic acid anti-inflammatory review
Primary Sources: 2026-03-22