Common Name(s): Plp,pyridoxal phosphate,p-5-p,active b6
CAS Number: 54-47-7
DESCRIPTION
What It Does: Provides immediately active b6 coenzyme activity for amino acid metabolism and collagen crosslinking.
Why It's Used: Premium formulations for superior b6 bioavailability without conversion, offering direct coenzyme activity.
How It Works: Cofactor for 100+ enzymes including lysyl oxidase (collagen/elastin crosslinking) and transaminases.
Typically Found In: Premium serums,anti-aging formulations
TECHNICAL DETAILS
Primary Category: Active ingredient – vitamin b6 active form
Secondary Functions: Collagen crosslinking,amino acid metabolism
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%–0.5%
SOURCING & ETHICS
Vegan Status: Yes – synthetically produced
Halal Status: Yes
Source Notes: Synthetically produced for cosmetic use.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 – very low
Comedogenicity Rating: 0/5 – non-comedogenic
Sensitivity Concerns: Non-irritating; excellent tolerability.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Other b vitamins,niacinamide,antioxidant complexes
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Plp's role as cofactor for lysyl oxidase – the enzyme responsible for collagen and elastin crosslinking – makes it directly relevant to skin structural integrity and anti-aging.
Last Verified: Cosing database,cir safety assessment
Primary Sources: 2026-03-12