Common Name(s): Poria cocos polysaccharide,poria cocos polysaccharide,poria cocos (fu ling) fungal polysaccharide,immunomodulating anti-tumor anti-inflammatory
CAS Number: N/a
DESCRIPTION
What It Does: Provides pachyman beta-glucan dectin-1 receptor-mediated skin immunity training, nf-kb anti-inflammatory cytokine suppression, and skin conditioning from the polysaccharide's hygroscopic film-forming character.
Why It's Used: Poria cocos is the most frequently prescribed herb in tcm formulations โ the pachyman beta-glucan providing the immunomodulating mechanism underpinning numerous traditional applications for immune support and inflammation.
How It Works: Pachyman (ฮฒ-1,3-glucan with ฮฒ-1,6 branches): dectin-1 receptor โ card9/bcl10/malt1 โ nf-kb (but then resolves into anti-inflammatory trained immunity). nf-kb direct inhibition: triterpenoid co-actives (pachymic acid, tumulosic acid) competitively inhibit ikk-ฮฒ. beta-glucan film: hydrophilic polysaccharide forms humectant skin conditioning film.
Typically Found In: Anti-inflammatory,microbiome skin care,anti-aging
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.1%โ5%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Poria cocos extract standardisation: active quality is determined by beta-glucan content (minimum 70% pachyman) and specific rotation โ standardised poria polysaccharide extract with coa ensures consistent dectin-1 pharmacological activity across batches.
Last Verified: Cosing database,poria cocos polysaccharide poria cocos pachyman beta-glucan immunomodulating review
Primary Sources: 2026-03-22