Common Name(s): Phosphorothioate dna-1,phosphorothioate dna-1,modified antisense oligonucleotide,nuclease-resistant gene silencing active
CAS Number: N/a
DESCRIPTION
What It Does: Provides nuclease-resistant antisense gene silencing targeting specific pro-inflammatory or pro-aging mrna sequences โ the phosphorothioate modification extending in-skin half-life from minutes (unmodified dna) to hours for effective gene knockdown.
Why It's Used: Phosphorothioate modification is the foundational chemistry of all approved antisense drugs โ the sulfur replacement converting rapidly degraded dna to a nuclease-resistant therapeutic oligonucleotide applicable to cosmetic gene targeting.
How It Works: Phosphorothioate (ps): phosphate p=o โ p=s replacement โ sulfur's larger ionic radius and lower electronegativity โ reduced rnase h binding but maintained watson-crick hybridisation โ rnase h-mediated mrna cleavage at dna/rna hybrid. nuclease resistance: ps sulfur doesn't coordinate znยฒโบ/mgยฒโบ in nuclease active sites โ >100ร slower degradation versus unmodified phosphodiester.
Typically Found In: Advanced anti-aging biotech,gene targeting
TECHNICAL DETAILS
Primary Category: Active ingredient โ cosmetic active
Secondary Functions: Skin conditioning
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.001%โ0.1%
SOURCING & ETHICS
Vegan Status: Conditional - supplier confirmation required
Halal Status: Unverified - supplier confirmation required
Source Notes: Commercially produced for cosmetic use. verify vegan/halal status with supplier. [audit 2026-07-29 rev2: the record's own source_notes does not assert a non-animal origin, or instructs the reader to verify with the supplier; "yes" asserts knowledge the record does not hold. determination requires shariah-panel sign-off.]
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Well-tolerated by most skin types.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Good safety profile at recommended concentrations. ewg score: 1โ2.
Works Well With: Standard skincare actives
Avoid Combining With: No known significant incompatibilities
SCIENTIFIC NOTE
Cosmetic gene silencing boundary: antisense oligonucleotides targeting mrna in cosmetics require regulatory boundary assessment โ if the claim involves treating a disease (not just improving appearance), pharmaceutical classification applies. cosmetic claims must remain aesthetic.
Last Verified: 2026-03-22
Primary Sources: Cosing database,phosphorothioate dna-1 antisense nuclease resistant gene silencing review