Common Name(s): Phloridzin,phloridzin,apple bark dihydrochalcone,sglt2 inhibitor brightening anti-glycation active
CAS Number: N/a
DESCRIPTION
What It Does: Provides sglt-mediated glucose transport reduction for anti-glycation protection of skin collagen, tyrosinase inhibitory brightening from the dihydrochalcone pharmacophore, and potent antioxidant radical scavenging.
Why It's Used: Phloridzin is historically significant as the first compound to demonstrate sglt inhibition (1835) โ the same mechanism later developed into the gliflozin pharmaceutical class. topically, the sglt inhibition reduces keratinocyte glucose uptake reducing local glycation of sc proteins.
How It Works: Phloridzin: competitive sglt1/2 inhibition (kd ~200 nm) โ reduced intracellular glucose โ reduced maillard reaction on skin proteins โ anti-glycation. phloretin aglycone (from skin glucosidase hydrolysis): competitive tyrosinase inhibition (ic50 ~30 ฮผm) โ brightening. dihydrochalcone alpha,beta-unsaturated carbonyl: radical scavenging from phenol h-atom donation.
Typically Found In: Anti-aging,brightening,anti-glycation
TECHNICAL DETAILS
Primary Category: Active ingredient โ antioxidant
Secondary Functions: Free radical scavenging,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 0.01%โ1%
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Plant-derived extract or synthetic.
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating; well-tolerated.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Vitamin c,vitamin e,ferulic acid,spf,other antioxidants
Avoid Combining With: No significant incompatibilities
SCIENTIFIC NOTE
Phloridzin bioavailability: skin glucosidase converts phloridzin to phloretin aglycone (ic50 30 ฮผm tyrosinase โ stronger than arbutin) โ the glycoside providing better aqueous solubility and formulation stability than direct phloretin with skin-mediated activation providing the more potent aglycone at the delivery site.
Last Verified: 2026-03-22
Primary Sources: Cosing database,phloridzin apple dihydrochalcone sglt anti-glycation brightening review