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PHENACETIN

Description

Phenacetin is a synthetic compound that was once widely used as an analgesic and antipyretic drug. Chemically known as N-(4-ethoxyphenyl)acetamide, it belongs to the para-aminophenol class of medications. Phenacetin was first synthesized in 1887 and gained popularity for its pain-relieving and fever-reducing properties.

In skincare formulations, phenacetin has been utilized for its potential anti-inflammatory and soothing effects. It may help reduce redness and irritation associated with various skin conditions. However, its use in cosmetic products has become limited due to safety concerns.

Phenacetin's mechanism of action involves inhibiting prostaglandin synthesis, which contributes to its analgesic and antipyretic effects. When applied topically, it may penetrate the skin and provide localized relief.

Despite its historical significance, phenacetin has been largely phased out of pharmaceutical and cosmetic use in many countries. This is due to its association with nephrotoxicity and potential carcinogenic effects with long-term use. Regulatory bodies have imposed restrictions on its application, and safer alternatives are now preferred in both medical and skincare contexts.