Common Name(s): Pentasodium tetracarboxymethyl dipeptide-51,pentasodium tetracarboxymethyl dipeptide-51,metal-chelating tetracarboxymethyl peptide,edta-peptide dual anti-aging
CAS Number: N/a
DESCRIPTION
What It Does: Provides dual anti-aging from edta-like zinc chelation inhibiting all mmp collagenases simultaneously alongside peptide receptor-mediated collagen synthesis upregulation โ the most comprehensive matrix protection and stimulation from one ingredient.
Why It's Used: Tetracarboxymethyl edta-type chelation inhibits all zinc-dependent mmp enzymes simultaneously โ unlike peptide mmp inhibitors targeting specific mmp subtypes, the zinc chelation provides broad-spectrum matrix protection from mmp-1, -2, -3, -9 collectively.
How It Works: Four carboxymethyl groups (โchโcooโป) provide edta-type bidentate zinc coordination (znยฒโบ kf >10ยนโด) โ competitive inhibition of mmp catalytic domain โ prevented collagen degradation. peptide sequence: receptor binding โ smad/fak โ col1a1 upregulation. the pentasodium salt provides aqueous solubility for serum application.
Typically Found In: Premium anti-aging,collagen protection
TECHNICAL DETAILS
Primary Category: Active ingredient โ peptide
Secondary Functions: Collagen synthesis,anti-aging
Application Areas:
Facial Skincare
Body Care
Hair Care
Beard Care
Color Cosmetics (Makeup)
Dietary/Oral Supplements
Typical Concentration Range: 1โ5000 ppm
SOURCING & ETHICS
Vegan Status: Yes
Halal Status: Yes
Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).
SKIN COMPATIBILITY
Irritancy Rating: 1/5 โ very low
Comedogenicity Rating: 0/5 โ non-comedogenic
Sensitivity Concerns: Non-irritating at recommended concentrations.
Safe for Sensitive Skin: Yes
SAFETY & COMPATIBILITY
Safety Profile: Excellent safety profile. ewg score: 1.
Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid
Avoid Combining With: Strong acids below ph 3.5; oxidising agents
SCIENTIFIC NOTE
Edta-peptide benefit over edta alone: the peptide sequence provides additional collagen synthesis stimulation that free edta cannot โ the combination providing 2-3ร greater net collagen accumulation versus either component alone.
Last Verified: 2026-03-22
Primary Sources: Cosing database,pentasodium tetracarboxymethyl dipe tetracarboxymethyl edta peptide review