Common Name(s): Pentapeptide-26,pentapeptide-26,five-residue anti-aging signal peptide,collagen synthesis active

CAS Number: N/a

DESCRIPTION

What It Does: Stimulates fibroblast collagen i and iii synthesis and inhibits mmp-mediated degradation — providing measurable wrinkle reduction and skin firmness from five-residue peptide receptor pharmacology at 1-5000 ppm.

Why It's Used: Five-residue peptides represent the sweet spot of signal peptide design — short enough for maximum sc penetration without anchoring (mw ~500-700 da), but long enough for full receptor binding site contact.

How It Works: Pentapeptide receptor binding → map kinase or smad cascade → col1a1/col3a1 upregulation + mmp-1/mmp-3 downregulation. spps synthesis provides >98% sequence purity for reproducible pharmacological response.

Typically Found In: Anti-aging serums,collagen products

TECHNICAL DETAILS

Primary Category: Active ingredient – peptide

Secondary Functions: Collagen synthesis,anti-aging

Application Areas:

Typical Concentration Range: 1–5000 ppm

SOURCING & ETHICS

Vegan Status: Yes

Halal Status: Yes

Source Notes: Synthetically produced via solid-phase peptide synthesis (spps).

SKIN COMPATIBILITY

Irritancy Rating: 1/5 – very low

Comedogenicity Rating: 0/5 – non-comedogenic

Sensitivity Concerns: Non-irritating at recommended concentrations.

Safe for Sensitive Skin: Yes

SAFETY & COMPATIBILITY

Safety Profile: Excellent safety profile. ewg score: 1.

Works Well With: Retinoids,niacinamide,vitamin c,hyaluronic acid

Avoid Combining With: Strong acids below ph 3.5; oxidising agents

SCIENTIFIC NOTE

Pentapeptide-5 (kttks) is the benchmark reference sequence — the five residues lys-thr-thr-lys-ser from human procollagen i c-propeptide providing the documented collagen synthesis-stimulating signal. all numbered pentapeptides target complementary receptor subtypes.

Last Verified: 2026-03-22

Primary Sources: Cosing database,pentapeptide-26 anti-aging signal peptide review